Patents Assigned to Board of
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Publication number: 20240176890Abstract: Various embodiments of systems and methods for an at-risk system identification via analysis of discussions from various online hacker communities are disclosed herein.Type: ApplicationFiled: June 28, 2023Publication date: May 30, 2024Applicants: Arizona Board of Regents on Behalf of Arizona State University, Cyber Reconnaissance, Inc.Inventors: Eric Nunes, Jana Shakarian, Paulo Shakarian, Mohammed Almukaynizi, Harshdeep Singh, Gerardo Simari, Anant Sharma
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Publication number: 20240177812Abstract: A system can apply a Global Reduced Order Modeling (ROM), a Zonal ROM, or a Layer-By-Layer analysis method to accelerate computations of a static displacement field of a substrate during modeling of thermo-compression bonding. The system fully takes into account a glass transition of dielectric substrates as well as nonhomogeneity of the various layers.Type: ApplicationFiled: November 30, 2023Publication date: May 30, 2024Applicant: Arizona Board of Regents on Behalf of Arizona State UniversityInventors: Marc Mignolet, Xiaoquan Wang
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Publication number: 20240177805Abstract: A computer-implemented method of training a neural network to improve a characteristic of a protein comprises collecting a set of amino acid sequences from a database, compiling each amino acid sequence into a three-dimensional crystallographic structure of a folded protein, training a neural network with a subset of the three-dimensional crystallographic structures, identifying, with the neural network, a candidate residue to mutate in a target protein, and identifying, with the neural network, a predicted amino acid residue to substitute for the candidate residue, to produce a mutated protein, wherein the mutated protein demonstrates an improvement in a characteristic over the target protein. A system for improving a characteristic of a protein is also described. Improved blue fluorescent proteins generated using the system are also described.Type: ApplicationFiled: November 28, 2022Publication date: May 30, 2024Applicant: Board of Regents, The University of Texas SystemInventors: Andrew Ellington, Austin Cole, Raghav Shroff, Ross Thyer
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Publication number: 20240174685Abstract: Methods and compositions for agonizing a type-2 orexin receptor (OX2R) in a cell determined to be in need thereof, including the general method of (a) administering to a subject a cyclic guanidinyl OX2R agonist and (b) detecting a resultant enhanced wakefulness or increased resistance to diet-induced accumulation of body fat, or abbreviated recovery from general anesthesia or jet lag.Type: ApplicationFiled: February 8, 2024Publication date: May 30, 2024Applicant: Board of Regents, The University of Texas SystemInventors: Jef De Brabander, Daniel Rosenbaum, Qiren Liang, Wentian Wang
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Publication number: 20240175088Abstract: Processes and materials to detect cancer from a biopsy are described. In some cases, cell-free nucleic acids can be sequenced, and the sequencing result can be utilized to detect sequences derived from a neoplasm. Detection of somatic variants occurring in phase can indicate the presence of cancer in a diagnostic scan and a clinical intervention can be performed.Type: ApplicationFiled: February 7, 2024Publication date: May 30, 2024Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: David M. Kurtz, Maximilian Diehn, Arash Ash Alizadeh
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Publication number: 20240173277Abstract: The subject invention provides oligo(carbamoylated guanidine)s (OCGs) having fast and selective mycobactericidal effects via disruption of the mycobacterial membrane potential. OCGs also potentiates bedaquiline, an oxidative phosphorylation-targeting anti-TB drug. The combination of OCG and anti-TB drug can be used as an effective therapy for treating tuberculosis.Type: ApplicationFiled: November 10, 2023Publication date: May 30, 2024Applicant: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEESInventors: JOONG HO MOON, MICHELLE MIRANDA
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Publication number: 20240175752Abstract: Systems and methods for compact and low-cost vibrational spectroscopy platforms are described. Many embodiments implement deep learning processes to identify the relevant optical spectral features for the identification of an element from a set of elements. Several embodiments provide that resolution reduction and feature selection render efficient data analysis processes. By reducing the spectral data from the full wide-band high-resolution spectrum to a subset of spectral bands, a number of embodiments provide compact and low-cost hardware incorporation in spectroscopic platforms for element identification functions.Type: ApplicationFiled: March 30, 2022Publication date: May 30, 2024Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Jennifer A. Dionne, Ahmed Shuaibi, Amr A. E. Saleh
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Publication number: 20240173361Abstract: Provided herein are methods and compositions for the treatment of cancer by modulating the microbiome to enhance the efficacy of immune checkpoint blockade. The microbiome may be modulated by the administration of butyrate and/or butyrate-producing bacteria. Also provided herein are methods of determining a response to an immune checkpoint inhibitor by identifying if a subject has a favorable microbial profile.Type: ApplicationFiled: February 13, 2024Publication date: May 30, 2024Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Jennifer WARGO, Vancheswaran GOPALAKRISHNAN
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Publication number: 20240173460Abstract: The disclosure relates to defined solutions for organ (heart, liver, kidney, etc,) vascular composite allografts or autografts (VCA: hand, limb, face, etc.) or tissue (peripheral nerves, spinal cord, skin) storage that preserve the electrophysiological functions of axons contained therein. The disclosure also concerns the use of isolated peripheral nerve segments and solid organs preserved in the defined solutions in autograft or allograft transplantation procedures, as well as the use of isolated peripheral nerve segments and solid organs preserved in the defined solutions in autograft/allograft transplantation procedures in combination with the peripheral nerve repair techniques of neurorrhaphy and axonal fusion primarily using polyethylene glycol known as PEG-fusion.Type: ApplicationFiled: November 20, 2023Publication date: May 30, 2024Applicant: Board of Regents, The University of Texas SystemInventors: George D. BITTNER, David M. JACKSON
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Publication number: 20240173355Abstract: The present disclosure provides methods and compositions for treating RAG2 deficiencies in subjects, comprising genetically modifying cells from the subjects ex vivo by integrating a functional, codon-optimized RAG 2 cDNA at the endogenous RAG2 locus.Type: ApplicationFiled: April 5, 2022Publication date: May 30, 2024Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Mara Pavel-Dinu, Matthew H. Porteus
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Publication number: 20240174604Abstract: The present disclosure provides one or more amino lipids such as an amino lipids containing a sulfonic acid or sulfonic acid derivative of the formulas: wherein the variables are as defined herein. These amino lipids may be used in compositions with one or more helper lipids and a nucleic acid therapeutic agent. These compositions may be used to treat a disease or disorder such as cancer, cystic fibrosis, or other genetic diseases.Type: ApplicationFiled: May 10, 2023Publication date: May 30, 2024Applicant: The Board of Regents of The University of Texas SystemInventors: Daniel J. SIEGWART, Jason B. MILLER
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Publication number: 20240173370Abstract: Provided herein are hydrogels that include a plurality of bacteriophages located within and covalently bonded to the hydrogel interior. The hydrogel is engineered to facilitate a controlled sustained release of the connected bacteriophages, e.g., to or within the body of a patient suffering from a bacterial infection. Also provided are methods for forming the provided hydrogels, and for using the hydrogels to treat a patient suffering from a bacterial infection.Type: ApplicationFiled: March 25, 2022Publication date: May 30, 2024Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Ovijit CHAUDHURI, Paul L. BOLLYKY, Robert MANASHEROB, Yung-Hao LIN, Derek AMANATULLAH
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Patent number: 11992013Abstract: A composition and method for killing feral hogs: a bait that is attractive to hogs is mixed with a lethal amount of sodium nitrite, along with sufficient base to inhibit decomposition of the sodium nitrite. At sufficiently high pH, encapsulation of the sodium nitrite is not required to inhibit decomposition. In the absence of substantial decomposition, the sodium nitrite itself is not aversive to the pigs, and may even enhance acceptance of the baits by the pigs. Optionally, an anti-emetic compound is added to the mixture to reduce the likelihood the bait will be vomited. Optionally, an additional toxicant such as luteolin is added to the mixture.Type: GrantFiled: June 8, 2023Date of Patent: May 28, 2024Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Glen Gentry, John Pojman, Baylen Thompson
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Patent number: 11992801Abstract: A device, system, and method for small scale CO2 extraction is disclosed. The device includes a sorbent bed having a sorbent resin. The device also includes a blower in fluid communication with the sorbent bed through at least one duct, as well as a collection tray beneath the sorbent bed and having a drain. The device also includes a capture configuration and a regeneration configuration. The capture configuration includes an air flow driven by the blower passing through the sorbent resin. The regeneration configuration includes the flooding of at least the sorbent resin with regeneration fluid. The regeneration fluid has a higher dissolve inorganic carbon concentration after flooding the sorbent resin. Multiple devices may be employed together as a system capable of providing a continuous product stream having an upgraded concentration of CO2.Type: GrantFiled: April 9, 2020Date of Patent: May 28, 2024Assignee: Arizona Board of Regents on Behalf of Arizona State UniversityInventor: Klaus Lackner
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Patent number: 11992028Abstract: The present invention describes a bio-based process to produce high quality protein concentrate (HQPC) by converting plant derived celluloses into bioavailable protein via aerobic incubation, including the use of such HQPC so produced as a nutrient, including use as a fish meal replacement in aquaculture diets.Type: GrantFiled: September 27, 2022Date of Patent: May 28, 2024Assignee: The South Dakota Board of Regents, as Governing Board for South Dakota State UniversityInventors: William Gibbons, Michael L Brown
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Patent number: 11991996Abstract: A fishing reel includes: a reel body; a spool supported by the reel body so as to be rotatable; a handle attached to the reel body so as to be rotatable; a first rotation transmission mechanism that transmits, to the spool, a driving force due to rotation of the handle; a motor power unit that generates a driving force that rotates the spool; a second rotation transmission mechanism that transmits the driving force of the motor power unit to the spool; and an operation unit that is disposed outside the reel body and changes the driving force of the motor power unit, wherein the operation unit is configured to be set at a position desired by a user so as to be usable.Type: GrantFiled: October 27, 2022Date of Patent: May 28, 2024Assignee: BLUE BOARD LTD.Inventor: Yasuyuki Suginami
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Patent number: 11992319Abstract: Neural interfaces with the peripheral nervous system have been developed to provide a direct communication pathway between peripheral nerves and prosthetic limbs. Described herein is a method of making a microchannel integrated neural interface device comprising a plurality of hollow cylindrical electrodes in a PDMS scaffold, which can control the reinnervated muscles and interpret neurological signals. The acquired bioelectrical signals can be used for the interpretation of mind and create a neural map.Type: GrantFiled: October 25, 2019Date of Patent: May 28, 2024Assignee: The Board of Regents of The University of Texas SystemInventors: Paul Yoonsu Choi, Bong Kyun Kim, Bernardo Garza
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Patent number: 11992024Abstract: A method of producing a low-lactose milk protein concentrate comprising the steps of providing a starting liquid milk protein concentrate, pre-treating the milk protein concentration by ultra-sonication, and treating the pre-treated milk protein concentration by diafiltration to provide a calcium depleted low-lactose milk protein concentrate. The process of the invention provides a milk protein concentrate with high levels of protein, less than 1% lactose, and a calcium level that is depleted by at least 20% compared with an untreated milk protein concentrate.Type: GrantFiled: June 22, 2022Date of Patent: May 28, 2024Assignee: The Provost, Fellows, Scholars and Other Members of Board of Trinity College DublinInventors: Ramesh Babu Padamati, Mukesh Prabhakar Pednekar
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Patent number: 11993556Abstract: Novel peptoid compounds, compositions and methods of using the compounds and compositions to inhibit protein arginine methyltransferase (PRMT) and induce apoptosis in cancer cells are presented.Type: GrantFiled: November 16, 2021Date of Patent: May 28, 2024Assignee: University of North Florida Board of TrusteesInventors: Bryan Knuckley, Corey P. Causey, Fatima Khwaja Rehman
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Patent number: D1029161Type: GrantFiled: May 8, 2021Date of Patent: May 28, 2024Assignee: SHENZHEN MEEPO BOARD LIMITEDInventor: Li Mao