Patents Assigned to Board of Regents of the University of Nebraska at Lincoln
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Publication number: 20110166827Abstract: Systems and methods for determining a trend in vertical track modulus are disclosed in accordance with embodiments of the present invention. Vertical deflection data is collected along a particular section of railroad track. A first set of vertical track modulus is determined, based in part, on the collected vertical deflection data. At a second time, vertical deflection data is again collected along the particular section of railroad track to be used in determining a second set of vertical track modulus. At least the first and second sets of vertical track modulus are analyzed to determine a mathematical algorithm that facilitates developing a trend in the vertical track modulus of the railroad track.Type: ApplicationFiled: March 11, 2011Publication date: July 7, 2011Applicant: Board of Regents of the University of Nebraska at LincolnInventors: Shane Michael Farritor, Sheng Lu
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Publication number: 20090305347Abstract: The present invention is directed to recombinant nucleic acid constructs comprising nucleic acid sequences encoding a Pichia pastoris PIR secretion signal peptide for secretion or an anchor domain peptide for surface display of a heterologous polypeptide. The present invention is further directed to methods for obtaining a heterologous polypeptide secreted into the culture medium or displayed on the cell surface. The present invention is also directed to transformed cells containing the recombinant nucleic acid constructs.Type: ApplicationFiled: June 2, 2009Publication date: December 10, 2009Applicant: BOARD OF REGENTS UNIVERSITY OF NEBRASKA-LINCOLNInventor: Mehmet Inan
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Publication number: 20090269807Abstract: Recombinant nucleic acid constructs for the efficient expression of eukaryotic selenoproteins and related methods for production of recombinant selenoproteins are provided. The nucleic acid constructs comprise novel selenocysteine insertion sequence (SECIS) elements. Certain novel SECIS elements of the invention contain non-canonical quartet sequences. Other novel SECIS elements provided by the invention are chimeric SECIS elements comprising a canonical SECIS element that contains a non-canonical quartet sequence and chimeric SECIS elements comprising a non-canonical SECIS element that contains a canonical quartet sequence. The novel SECIS elements of the invention facilitate the insertion of selenocysteine residues into recombinant polypeptides.Type: ApplicationFiled: April 22, 2009Publication date: October 29, 2009Applicant: Board of Regents of the University of Nebraska- LincolnInventors: Vadim Gladyshev, Sergey Novoselov
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Patent number: 7371571Abstract: Recombinant mycobacterial strains which overproduce essential biosynthetic enzymes of pathogenic mycobateria are provided. These strains overproduce enzymes involved in the synthesis and incorporation of D-alanine into mycobacterial peptidoglycan, the backbone of the mycobacterial cell wall. These overproducing strains may be used as reference strains in in vitro screening methods to identify antimycobacterial agents.Type: GrantFiled: December 17, 2003Date of Patent: May 13, 2008Assignee: Board of Regents University of Nebraska - LincolnInventors: Raul G. Barletta, Zhengyu Feng
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Patent number: 6929799Abstract: The present invention is directed to D-alanine racemase mutants of mycobacterial species. The D-alanine racemase gene (alrA) is involved in the systhesis of D-alanine, a basic component of peptidoglycan that forms the backbone of the bacterial cell wall. The present invention is also directed to methods of making live-attenuated vaccines against pathogenic mycobacteria using such alrA mutants and to the vaccines made according to such methods. The present invention is further directed to use of alrA mutants in methods for screening antimycobacterial agents that are synergistic with peptidoglycan inhibitors. Finally, the present invention is directed to methods to identify new pathways of D-alanine biosynthesis for use in developing new drugs targeting peptidoglycan biosynthesis in mycobacteria and to identify vaccines useful against pathogenic mycobacteria.Type: GrantFiled: December 18, 2002Date of Patent: August 16, 2005Assignee: Board of Regents University of Nebraska-LincolnInventors: Raul G. Barletta, Ofelia Barletta-Chacon
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Publication number: 20040241830Abstract: Recombinant mycobacterial strains which overproduce essential biosynthetic enzymes of pathogenic mycobateria are provided. These strains overproduce enzymes involved in the synthesis and incorporation of D-alanine into mycobacterial peptidoglycan, the backbone of the mycobacterial cell wall. These overproducing strains may be used as reference strains in in vitro screening methods to identify antimycobacterial agents.Type: ApplicationFiled: December 17, 2003Publication date: December 2, 2004Applicant: The Board of Regents, University of Nebraska-LincolnInventors: Raul G. Barletta, Zhengyu Feng
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Publication number: 20040185056Abstract: Vaccines for pathogenic strains of bovine herpesvirus 1 (BHV-1) which are based on attenuated BHV-1 having a mutation in the latency-related gene are provided. Live, attenuated vaccines are also provided which express antigens from other viral or bacterial pathogens and thus form the basis of a variety of vaccines.Type: ApplicationFiled: January 5, 2004Publication date: September 23, 2004Applicant: Board of Regents, University of Nebraska-LincolnInventor: Clinton J. Jones
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Patent number: 6673537Abstract: The invention is directed to novel promoters or mutants thereof from Chlorella virus DNA methyltansferase genes. A Chlorella virus gene promoter is operably linked to a first and/or second DNA sequence encoding a gene that is different from the Chlorella virus to form an expression cassette. An expression cassette can be introduced into prokaryotic and/or eukaryotic cells and can provide for a high level of expression of the gene encoded by the first and/or second DNA sequence. The invention also provides a method for screening other Chlorella virus genes for promoters that can function to express a heterologous gene in prokaryotic and/or eukaryotic hosts.Type: GrantFiled: October 12, 1999Date of Patent: January 6, 2004Assignee: Board of Regents, University of Nebraska-LincolnInventors: Amitava Mitra, James L. Van Etten
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Patent number: 6600177Abstract: The present invention relates to the fabrication of a boron carbide/boron semiconductor devices. The results suggest that with respect to the approximately 2 eV band gap pure boron material, 0.9 eV band gap boron carbide (B5C) acts as a p-type material. Both boron and boron carbide (B5C) thin films were fabricated from single source borane cage molecules using plasma enhanced chemical vapor deposition (PECVD). Epitaxial growth does not appear to be a requirement. We have doped boron carbide grown by plasma enhanced chemical vapor deposition. The source gas closo-1,2-dicarbadecaborane (orthocarborane) was used to grow the boron carbide while nickelocene (Ni(C5H5)2) was used to introduce nickel into the growing film. The doping of nickel transformed a B5C material p-type relative to lightly doped n-type silicon to an n-type material. Both p-n heterojunction diodes and n-p heterojunction diodes with n- and p-type Si [1,1,1] respectively.Type: GrantFiled: November 16, 2001Date of Patent: July 29, 2003Assignee: Board of Regents, University of Nebraska-LincolnInventor: Peter A. Dowben
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Patent number: 6489589Abstract: The present invention teaches various femtosecond machining and drilling apparatus and processes for fabricating tools and the like from both traditional and non-traditional materials. Also described are novel tools such as scalpels, and nozzles fabricated from the apparatus and processes of the present invention. Likewise, the present invention may be utilized in both a novel propulsion system and the production of materials formed from nanometer sized particles and the like.Type: GrantFiled: March 5, 1998Date of Patent: December 3, 2002Assignee: Board of Regents, University of Nebraska-LincolnInventor: Dennis R. Alexander
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Patent number: 6440786Abstract: The present invention relates to the fabrication of a boron carbide/boron semiconductor devices. The results suggest that with respect to the approximately 2 eV band gap pure boron material, 0.9 eV band gap boron carbide (B5C) acts as a p-type material. Both boron and boron carbide (B5C) thin films were fabricated from single source borane cage molecules using plasma enhanced chemical vapor deposition (PECVD). Epitaxial growth does not appear to be a requirement. We have doped boron carbide grown by plasma enhanced chemical vapor deposition. The source gas close-1,2-dicarbadecaborane (orthocarborane) was used to grow the boron carbide while nickelocene (Ni(C5H5)2) was used to introduce nickel into the growing film. The doping of nickel transformed a B5C material p-type relative to lightly doped n-type silicon to an n-type material. Both p-n heterojunction diodes and n-p heterojunction diodes with n- and p-type Si [1,1,1] respectively.Type: GrantFiled: December 16, 1999Date of Patent: August 27, 2002Assignee: Board of Regents, University of Nebraska-LincolnInventor: Peter A. Dowben
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Patent number: 6392032Abstract: Heavily fluorinated sugar analogs of formula wherein R1 is selected from alkyl, alkenyl, aryl, —CH2—O-alkyl, —CH2—O-aryl, —CH2OPO3H, —CH2—O-carbohydrate, —CH2—NH-peptide, or —CH2—O-peptide; wherein R2 is selected from hydroxy, —O-carbohydrate, —NH-peptide, wherein R3 is selected from H, halogen, lower alkyl, lower alkenyl, lower haloalkyl, lower haloalkenyl, amino, mono- or di-lower alkylamino; wherein R4 is selected from amino, hydroxy, alkoxy, or halogen; and wherein R5 is H or amino. The compounds of formula (I) are useful as antiviral and antineoplastic agents and the compounds of formula (II) are useful as plant growth inhibitors and herbicides.Type: GrantFiled: September 2, 1999Date of Patent: May 21, 2002Assignee: Board of Regents University of Nebraska-LincolnInventor: Stephen G. Dimagno
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Patent number: 6379664Abstract: Thioltransferase and derivatives thereof are provided. Methods of treating or preventing cataract formation comprising administering thioltransferase or a derivative thereof are also provided. Thioltransferase or derivatives thereof are also useful for treating or preventing diseases resulting from or associated with oxidative stress. Human lens thioltransferase and a DNA sequence encoding the same are also provided.Type: GrantFiled: September 29, 1998Date of Patent: April 30, 2002Assignee: Board of Regents University of Nebraska-LincolnInventors: Marjorie F. Lou, Nalini Raghavachari, Fengyu Qiao
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Publication number: 20020045300Abstract: The present invention relates to the fabrication of a boron carbide/boron semiconductor devices. The results suggest that with respect to the approximately 2 eV band gap pure boron material, 0.9 eV band gap boron carbide (B5C) acts as a p-type material. Both boron and boron carbide (B5C) thin films were fabricated from single source borane cage molecules using plasma enhanced chemical vapor deposition (PECVD). Epitaxial growth does not appear to be a requirement. We have doped boron carbide grown by plasma enhanced chemical vapor deposition. The source gas closo-1,2-dicarbadecaborane (orthocarborane) was used to grow the boron carbide while nickelocene (Ni(C5H5)2) was used to introduce nickel into the growing film. The doping of nickel transformed a B5C material p-type relative to lightly doped n-type silicon to an n-type material. Both p-n heterojunction diodes and n-p heterojunction diodes with n- and p-type Si [1,1,1] respectively.Type: ApplicationFiled: November 16, 2001Publication date: April 18, 2002Applicant: Board of Regents, University of Nebraska LincolnInventor: Peter A. Dowben
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Patent number: 6265333Abstract: A fiber reinforced composite material comprising a resin matrix and primary reinforcement fibers and further comprising secondary, smaller diameter, reinforcement fibers at one or more ply interfaces, or portion thereof, provides improved interlaminar toughness, strength, and delamination resistance without substantial reduction of in-plane properties and without substantial increase in weight. In one embodiment, the small fibers are attached to one side of a conventional prepreg prior to lamination. The small fibers are flexible and are expected to conform to the shape and distribution of the primary reinforcing fibers at the interface.Type: GrantFiled: December 1, 1998Date of Patent: July 24, 2001Assignee: Board of Regents, University of Nebraska-LincolnInventors: Yuris A. Dzenis, Darrell H. Reneker
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Patent number: 6139907Abstract: A high coercivity longitudinal recording media comprising FePt or similar thin films that are vacuum deposited by RF and DC sputtering. The as-deposited multilayered films are subjected to vacuum annealing. Due to the formation of the ordered phases of FePt or the like, which have very high crystal anisotropy, the annealed FePt films have large coercivity and fine grain size, suitable for use as ultra-high density magnetic recording media.Type: GrantFiled: May 14, 1998Date of Patent: October 31, 2000Assignee: Board of Regents, University of Nebraska-LincolnInventors: David J. Sellmyer, Chun-Ping Luo
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Patent number: 6099834Abstract: The invention is directed to compositions which alter the health of invertebrate organisms by affecting eicosanoid-mediated immune responses, and methods of using the compositions. The invention provides pharmaceutical compositions and biopesticide compositions. The pharmaceutical composition is composed of an effective amount of at least one biologically active agent which enhances or inhibits eicosanoid-mediated immune responses in invertebrate species and a physiological compatible carrier. The biopesticide composition is composed of a biopesticidal amount of an inhibitor of eicosanoid-mediated immune responses in invertebrates and a physiologically acceptable carrier. The pharmaceutical compositions are useful to treat invertebrate species to enhance or inhibit immune responses. The biopesticide composition is useful to control the growth of or eradicate invertebrate pests. Methods are provided for determining which and what amounts of the biologically active agents are useful in the composition.Type: GrantFiled: August 18, 1997Date of Patent: August 8, 2000Assignee: Board of Regents University of Nebraska-LincolnInventor: David W. Stanley
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Patent number: 6036906Abstract: A precast, prestressed concrete joist having web openings through which mechanical and electrical equipment may pass. In an exemplary embodiment, the joist comprises generally horizontal opposite top and bottom concrete members with a concrete web interposed between them. This web may have openings through which mechanical and electrical equipment may pass. Prestress steel strands may extend lengthwise through both the top and bottom members to provide prestress in the concrete joist. The concrete joist may further comprise strand restraining devices for deflecting the prestress steel strands. The precast, prestressed concrete joist having a web opening may be constructed using a reusable casting apparatus. This casting apparatus comprises a prestressing bed onto which a frame may be mounted. The frame provides a means of applying tension to the prestress steel strands and of supporting prestress strand restraining devices.Type: GrantFiled: July 29, 1997Date of Patent: March 14, 2000Assignee: Board of Regents University of Nebraska, LincolnInventors: Maher K. Tadros, Amin Einea, Mohsen Saleh
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Patent number: PP20013Abstract: A new and distinct Penstemon plant characterized by an upright, dense habit with very dark foliage, flowers of light purple shades, and excellent vigor.Type: GrantFiled: December 10, 2007Date of Patent: May 19, 2009Assignee: Board of Regents of the University of Nebraska-LincolnInventor: Dale Tennis Lindgren
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Patent number: PP11373Abstract: A vegetatively reproduced buffalograss cultivar named `NE91-118` is distinguished from other commercially produced buffalograss varieties by its excellent turfgrass color, cold tolerance, high density, low growth habit, and rate of establishment. `NE91-118` is also distinguished by molecular markers and nuclear DNA content. `NE91-118` is suitable for use in low to medium maintenance situations in arid and semi-arid climates of United States and Canada.Type: GrantFiled: October 22, 1997Date of Patent: May 9, 2000Assignee: Board of Regents University of Nebraska-LincolnInventors: Terrance P. Riordan, Frederick P. Baxendale, Roch E. Gaussoin, Jennifer M. Johnson-Cicalese, Paul G. Johnson, Edward John Kinbacher