Abstract: The present invention provides a method of treating heart failure with reduced ejection fraction, by administering to a patient at risk of such damage, a pharmaceutically effective amount of a composition which inhibits the anchoring of PP2A to mAKAP?. This composition is preferably in the form of a viral based gene therapy vector that encodes a fragment of mAKAP? to which PP2A binds.

Abstract: The present disclosure describes compositions of matter comprising a ribonucleoprotein complex comprising a nucleic acid-guided nuclease and a guide RNA, and further comprising a blocking nucleic acid molecule represented by Formula IV, wherein Formula IV in the 5?-to-3? direction comprises: T-D-M-A-Lp-C; wherein T is 17-31 nucleotides in length; D is 0-15 nucleotides in length; M is 1-25 nucleotides in length; A is 0-15 nucleotides in length and comprises a sequence complementary to D; and L is 3-25 nucleotides in length; p is 0 or 1; C is 4-15 nucleotides in length and comprises a sequence complementary to T; and wherein the blocking nucleic acid molecule comprises a sequence complementary to a gRNA.

Abstract: Systems, methods and devices are implemented for microscope imaging solutions. One embodiment of the present disclosure is directed toward an epifluorescence microscope. The microscope includes an image capture circuit including an array of optical sensor. An optical arrangement is configured to direct excitation light of less than about 1 mW to a target object in a field of view of that is at least 0.5 mm2 and to direct epi-fluorescence emission caused by the excitation light to the array of optical sensors. The optical arrangement and array of optical sensors are each sufficiently close to the target object to provide at least 2.5 ?m resolution for an image of the field of view.

Abstract: A brain machine interface (BMI) to control a device is provided. The BMI has a neural decoder, which is a neural to kinematic mapping function with neural signals as input to the neural decoder and kinematics to control the device as output of the neural decoder. The neural decoder is based on a continuous-time multiplicative recurrent neural network, which has been trained as a neural to kinematic mapping function. An advantage of the invention is the robustness of the decoder to perturbations in the neural data; its performance degrades less—or not at all in some circumstances—in comparison to the current state decoders. These perturbations make the current use of BMI in a clinical setting extremely challenging. This invention helps to ameliorate this problem. The robustness of the neural decoder does not come at the cost of some performance, in fact an improvement in performance is observed.

Abstract: Systems and methods are provided for color-coded visualization to aid in diagnosis and prognosis of Alzheimer's disease (AD). The color-coded visualization mechanism can be driven by an integrated machine learning (ML) model, which can take as its inputs neuroimaging (e.g., magnetic resonance imaging (MRI), positron emission tomography (PET)) data, neuropsychological test scores, the cerebrospinal fluid (CSF) biomarker, and/or risk factors. With these inputs, the ML model can generate a color-coded visualization of the disease state.

Abstract: A battery health monitoring system that utilizes adaptive cathode and adaptive anode observers to estimate the ion concentrations at the respective cathode and anode of a battery. Subsequently, the estimated ion concentrations can be used in a battery model to estimate the state of heath and state of charge of the battery. Additionally, the model and ion concentrations can be updated real time as aging components of the battery are evaluated in the output data from the battery.

Abstract: The present disclosure provides compounds, complexes, compositions, and methods for the detection of cancer. Specifically, the compounds, complexes, compositions of the present technology include pH (low) insertion peptides. Also disclosed herein are methods of using the complexes and compositions of the present technology in diagnostic imaging to detect cancer in a subject.

Abstract: A laser system employs a laser, a pulse shaper, and a controller configured to measure phase variations on pre-compressed laser pulses. In another aspect, a laser apparatus and method include programmed software instructions which measure phase variations of ultrafast laser pulses. A further aspect of the present system and method includes a laser, an active pulse shaper, and a controller which measure and/or correct distortions of laser pulses with ?/2 scanning.

Abstract: This disclosure provides methods of using BAF complex modulating compounds as inhibitors of BAF-mediated transcription in target cells. The BAF complex modulating compounds include 12-membered macrolactam compounds that can target a BAF-specific subunit (e.g., ARID1A) to prevent nucleosomal positioning, relieving transcriptional repression of HIV-1. The subject methods can provide for reversal of latency of HIV-1 in cells in vitro or in vivo. Use of the macrolactam BAF complex modulating compounds represent a method of HIV latency reversal with a unique mechanism of action, which can be optionally combined with other Latency Reversal Agents to improve reservoir targeting. The subject methods can be utilized in conjunction with any convenient methods of treating HIV or HIV latency, including methods related to immune system activation, antiretroviral therapies and/or anti-HIV agents.

Abstract: This specification discloses systems, methods, devices, and other techniques for determining the location of a seizure-generating region of the brain of a mammal.

Abstract: In one aspect, TEMPO-cellulose structures and method of making the same are described herein. Briefly, a method of synthesizing TEMPO-cellulose comprises disposing cellulose in an aqueous medium, disposing first and second oxidizing agents in the aqueous medium and oxidizing hydroxyl groups of the cellulose via the first and second oxidizing agents in the presence of a 2,2,6,6-tetramethylpiperidine 1-oxyl radical (TEMPO) catalyst.

Abstract: A method for scene synthesis from human motion is described. The method includes computing three-dimensional (3D) human pose trajectories of human motion in a scene. The method also includes generating contact labels of unseen objects in the scene based on the computing of the 3D human pose trajectories. The method further includes estimating contact points between human body vertices of the 3D human pose trajectories and the contact labels of the unseen objects that are in contact with the human body vertices. The method also includes predicting object placements of the unseen objects in the scene based on the estimated contact points.

Abstract: There are provided herein, inter alia, complexes, compositions and methods for a vaccine for COVID-19. The cell-penetrating complexes provided herein may include a nucleic acid non-covalently bound to a cationic amphipathic polymer, the cationic amphipathic polymer including a pH-sensitive immolation domain. The cell-penetrating complexes provided herein are, inter alia, useful in vaccines, wherein the vaccine includes a ribonucleic acid including a sequence encoding a viral protein, a nucleic acid adjuvant and a cationic amphipathic polymer provided herein including embodiments thereof.

Abstract: Systems and methods in accordance with various embodiments of the invention are capable of rapid analysis and classification of cellular samples based on cytomorphological properties. In several embodiments, cells suspended in a fluid medium are passed through a microfluidic channel, where they are focused to a single stream line and imaged continuously. In a number of embodiments, the microfluidic channel establishes flow that enables individual cells to each be imaged at multiple angles in a short amount of time. A pattern recognition system can analyze the data captured from high-speed images of cells flowing through this system and classify target cells. In this way, the automated platform creates new possibilities for a wide range of research and clinical applications such as (but not limited to) point of care services.

Abstract: Embodiments of the present disclosure pertain to a clamp assembly that includes: a first base and a second base; and a mold operational to be clamped between the first base and the second base. The clamp assembly is operational to stretch and compress the clamped mold without movement of the first base and the second base. For instance, each of the first base and the second base may include a plurality of apertures with pegs that are associated with the mold, where the pegs are operational for stretching and compressing the mold through adjustment. Further embodiments pertain to methods of moving a mold by utilizing the clamp assemblies of the present disclosure.

Abstract: A color-changing filament or yarn is provided that delivers fully-controllable full-spectrum response to current input. In embodiments, the filament is adapted to be woven into a textile and controlled to vary and maintain color independently of external temperature.

Abstract: Systems and methods for performing three-dimensional multi-object tracking are disclosed herein. In one example, a method includes the steps of determining a residual based on augmented current frame detection bounding boxes, augmented previous frame detection bounding boxes, augmented current frame shape descriptors, and augmented previous frame shape descriptors and predicting an affinity matrix using the residual. The residual indicates a spatiotemporal and shape similarity between current detections in a current frame point cloud data and previous detections in a previous frame point cloud data. The affinity matrix indicates associations between the previous detections and the current detections, as well as the augmented anchors.

Abstract: A method of preventing tissue adhesion includes forming an incision in tissue, applying a hydrogel to tissue through the incision, and closing the incision with the hydrogel therein. The hydrogel includes a polymer non-covalently cross-linked with a plurality of nanoparticles and prevents a formation of adhesions between tissues and/or organs.

Abstract: The present invention provides a swarm manufacturing platform, based on a swarm 3D printing and assembly (SPA) platform as a model for future smart factories, consisting of thousands of IoT-based mobile robots performing different manufacturing operations with different end effectors (e.g., material deposition, energy deposition, pick and place, removal of materials, screw driving, etc.) and real-time monitoring. The swarm manufacturing platform transforms a 1-D factory into a 2-D factory with manufacturing robots that can move across the 2-D factory floor, work cooperatively with each other on the same production jobs, and re-configure in real-time (i.e., the manufacturing robots can be digitally controlled to move, re-group, calibrate, and work on a new job in real-time).

Abstract: Described is a locomotive implant for usage within a predetermined magnetic field. In one embodiment magnetohydrodynamics is used to generate thrust with a plurality of electrodes. In another embodiment, asymmetric drag forces are used to generate thrust.