Patents Assigned to Board of Trustees of the Leland Stanford Junior University
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Patent number: 11885576Abstract: Various aspects as described herein are directed to a radiative cooling device and method for cooling an object. As consistent with one or more embodiments, a radiative cooling device includes a solar spectrum reflecting structure configured and arranged to suppress light modes, and a thermally-emissive structure configured and arranged to facilitate thermally-generated electromagnetic emissions from the object and in mid-infrared (IR) wavelengths.Type: GrantFiled: July 1, 2022Date of Patent: January 30, 2024Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Aaswath Pattabhi Raman, Shanhui Fan, Eden Rephaeli
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Patent number: 11883226Abstract: An x-ray apparatus includes an x-ray source capable of producing an x-ray beam with a focal spot having a spatial shape that is selected to pre-amplify predetermined spatial frequencies exceeding half a cutoff frequency as compared to spatial frequencies below half the cutoff frequency; an x-ray detector capable of detecting the x-ray beam; and a processor adapted to reconstruct an image from the detected x-ray beam using a filter that compensates the pre-amplified predetermined spatial frequencies. The spatial shape comprises two or more disconnected regions that preferably have widths less than that of a nominal focal spot, combined widths greater than or equal to that of a nominal focal spot, and are separated by less than three times a width of a nominal focal spot.Type: GrantFiled: October 12, 2021Date of Patent: January 30, 2024Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Norbert J. Pelc, Adam S. Wang
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Patent number: 11887317Abstract: A plurality of agent locations can be determined at a plurality of time steps by inputting a plurality of images to a perception algorithm that inputs the plurality of images and outputs agent labels and the agent locations. A plurality of first uncertainties corresponding to the agent locations can be determined at the plurality of time steps by inputting the plurality of agent locations to a filter algorithm that inputs the agent locations and outputs the plurality of first uncertainties corresponding to the plurality of agent locations. A plurality of predicted agent trajectories and potential trajectories corresponding to the predicted agent trajectories can be determined by inputting the plurality of agent locations at the plurality of time steps and the first uncertainties corresponding to the agent locations at the plurality of time steps to a variational autoencoder.Type: GrantFiled: August 30, 2021Date of Patent: January 30, 2024Assignees: Ford Global Technologies, LLC, The Board of Trustees of the Leland Stanford Junior UniversityInventors: Boris Ivanovic, Yifeng Lin, Shubham Shrivastava, Punarjay Chakravarty, Marco Pavone
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Publication number: 20240025776Abstract: Most nitrogen recovery techniques recover acidic ammonium fertilizers, and few enable alkaline ammonia recovery. Many embodiments provide multi-chamber electrochemical stripping reactors to recover alkaline ammonia and acidic ammonium from wastewater. The reactor combines electrodialysis and membrane stripping. The acidic and alkaline product portfolio for wastewater-derived ammonia expand implementation opportunities for nitrogen recovery.Type: ApplicationFiled: August 16, 2021Publication date: January 25, 2024Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: William A. Tarpeh, Anna Kogler, Brandon D. Clark, Matthew Junjie Liu, William Chow
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Publication number: 20240025945Abstract: Compounds useful as contrast agents in image-guided surgery are provided. The compounds comprise a latent cationic lysosomotropic fragment that is detectable upon cleavage by lysosomal proteases within treated tissues, particularly within tumors and other diseased tissues. Also provided are compositions comprising the compounds and methods for using the compounds, for example in dynamically monitoring protease activity in vivo during image-guided tumor resection surgery.Type: ApplicationFiled: November 8, 2022Publication date: January 25, 2024Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITYInventors: Matthew S. BOGYO, Martijn VERDOES, Leslie OFORI, Nimali P. WITHANA
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Publication number: 20240023809Abstract: Systems and methods for the detection of musculoskeletal anomalies are disclosed. Various embodiments are directed to methods to detect and treat anomalies, including fracture (e.g. clavicle), deformity (e.g. scoliosis), and other anomalies. Various embodiments utilize structured white light scanners, while additional embodiments utilize LiDAR to generate 3-dimensional (3D) topographic scans. Various embodiments obtain these scans via a mobile device, such as a mobile phone or tablet. Further embodiments utilize machine learning models to analyze the 3D scans to identify an anomaly and/or a treatment for such anomaly and/or monitor change of that condition over time.Type: ApplicationFiled: February 1, 2021Publication date: January 25, 2024Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Malcolm R. DeBaun, Michael J. Gardner
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Publication number: 20240023888Abstract: A system and method for identifying and treating a disease in a patient collects one or more data streams from sensors configured to detect biological signals generated within a patient's tissue over time. Patient data elements including one or more of demographic, clinical, laboratory, pathology, chemical, image, historical, genetic, and activity data for the patient is collected and processed with the data streams to generate a personalized digital phenotype (PDP). The PDP is compared to a digital taxonomy comprising prior data to classify the patient into one or more quantitative disease classifications to guide personalized intervention for treating the patient.Type: ApplicationFiled: August 17, 2023Publication date: January 25, 2024Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Sanjiv M. NARAYAN, Mahmood ALHUSSEINI
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Publication number: 20240024664Abstract: Various methods and devices for treatment or assessment of structures or nerves accessible via the nasal cavity utilizing electrical stimulation or signal recording are provided. Devices can include one or more electrodes to provide electrical stimulation or signal recording. Electrodes can be disposed upon an inflatable balloon or a flat-surfaced tool or a precision tip.Type: ApplicationFiled: September 10, 2021Publication date: January 25, 2024Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventor: Zara Marzban Patel
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Publication number: 20240026460Abstract: Processes and materials to detect cancer from a biopsy are described. In some cases, cell-free nucleic acids can be sequenced, and the sequencing result can be utilized to detect sequences derived from a neoplasm. Detection of somatic variants occurring in phase can indicate the presence of cancer in a diagnostic scan and a clinical intervention can be performed.Type: ApplicationFiled: February 10, 2023Publication date: January 25, 2024Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: David M. Kurtz, Maximilian Diehn, Arash Ash Alizadeh
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Patent number: 11880962Abstract: Methods and systems for synthesizing contrast images from a quantitative acquisition are disclosed. An exemplary method includes performing a quantification scan, using a trained deep neural network to synthesize a contrast image from the quantification scan, and outputting the contrast image synthesized by the trained deep neural network. In another exemplary method, an operator can identify a target contrast type for the synthesized contrast image. A trained discriminator and classifier module determines whether the synthesized contrast image is of realistic image quality and whether the synthesized contrast image matches the target contrast type.Type: GrantFiled: February 14, 2019Date of Patent: January 23, 2024Assignees: GENERAL ELECTRIC COMPANY, THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITYInventors: Suchandrima Banerjee, Enhao Gong, Greg Zaharchuk, John M. Pauly
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Patent number: 11877849Abstract: Survivors of central nervous system injury commonly present with spastic hypertonia. The affected muscles are hyperexcitable and can display involuntary static muscle tone and an exaggerated stretch reflex. These symptoms affect posture and disrupt activities of daily living. Symptoms are typically measured using subjective manual tests such as the Modified Ashworth Scale; however, more quantitative measures are necessary to evaluate potential treatments. The hands are one of the most common targets for intervention, but few investigators attempt to quantify symptoms of spastic hypertonia affecting the fingers. An Isometric Force Pillow (IFP) is provided herein to quantify involuntary grip force. This lightweight, computerized tool provides a holistic measure of finger flexion force and can be used in various orientations for clinical testing and to measure the impact of assistive devices.Type: GrantFiled: March 4, 2021Date of Patent: January 23, 2024Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Caitlyn E. Seim, Allison M. Okamura
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Publication number: 20240018493Abstract: The present disclosure provides compositions, systems, and methods for genome editing, efficient knock-in of large DNA fragments, and long-term, stable, high expression of integrated transgenes. Also provided are modified cells, vaccines comprising modified cells, and methods of using such cells to induce an immune response.Type: ApplicationFiled: November 10, 2021Publication date: January 18, 2024Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Michael G. CHAVEZ, Lei S. QI
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Publication number: 20240016784Abstract: Provided herein are novel azopodophyllotoxin analog compounds, pharmaceutical compositions comprising them, and their use as inhibitors of Y box protein 1 (YB1 or YBX1) in treatments for conditions including gynecological, breast, bladder, kidney, head and neck, neuronal, and prostate cancers, lymphomas, and leukemias. Methods of their use in sensitizing resistant cancers to treatment with anticancer agents and radiation are also provided.Type: ApplicationFiled: December 3, 2021Publication date: January 18, 2024Applicants: Oregon Health & Science University, The Board of Trustees of the Leland Stanford Junior UniversityInventors: Sanjay V. Malhotra, Dhanir Tailor, Arpit Dheeraj
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Publication number: 20240021018Abstract: Systems and methods of capturing privacy protected images and performing machine vision tasks are described. An embodiment includes a system that includes an optical component and an image processing application configured to capture distorted video using the optical component, where the optical component includes a set of optimal camera lens parameters ?*o learned using machine learning, performing a machine vision task on the distorted video, where the machine vision task includes a set of optimal action recognition parameters ?*c learned using the machine learning, and generating a classification based on the machine vision task, where the machine learning is jointly trained to optimize the optical element and the machine vision task.Type: ApplicationFiled: July 13, 2023Publication date: January 18, 2024Applicants: The Board of Trustees of the Leland Stanford Junior University, Universidad Industrial de SantanderInventors: Juan Carlos Niebles, Carlos Hinojosa, Henry Arguello, Miguel Marquez, Ehsan Adeli-Mosabbeb, Fei-Fei Li
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Patent number: 11872243Abstract: Compounds and compositions for the transient expression of exogenous telomerase activity in a cell are provided. The compounds and compositions, which relate to a ribonucleic acid coding for a telomerase reverse transcriptase, are useful in the extension of telomeres in cells needing such treatment. Such cells include, for example, cells that contain shortened telomeres and cells from subjects that may benefit from telomere extension, for example subjects that suffer from, or are at risk of suffering from, age-related or other illnesses. Also provided are methods of extending telomeres through the administration of the provided compounds and compositions to animal cells, either in vitro or in vivo, and kits including the compounds or compositions and instructions for use.Type: GrantFiled: January 6, 2020Date of Patent: January 16, 2024Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: John Ramunas, Eduard Yakubov, Helen M. Blau, John Cooke
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Publication number: 20240008798Abstract: Systems and methods for digitographic measurement of Parkinson's disease in accordance with embodiments of the invention are illustrated. One embodiment includes a digitographic measurement device, including a housing, a plurality of keys attached to the housing, a plurality of sensors, sensor in the plurality of sensors is associated with a key in the plurality of keys and is capable of measuring the amplitude of a key press, and an input/output interface within the housing, where the digitographic measurement device is configured to transmit key press data generated by the sensors to a controller via the input/output interface, and where the key press data is used to generate a plurality of digitographic metrics that describe motor symptoms of a user of the digitographic measurement device.Type: ApplicationFiled: July 29, 2021Publication date: January 11, 2024Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Helen Bronte-Stewart, Megan H. Trager, Simon Revlock
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Publication number: 20240010537Abstract: Systems and methods for managing and operating a water supply system in accordance with embodiments on the invention are described. In an embodiment, the system calculates a set of one or more marginal values for a water supply system by: determining a set of transmission marginal values for a transmission stage, determining a set of treatment marginal values for a treatment stage, and determining a set of distribution marginal values for a distribution stage for a set of consumers, where the determining includes backtracking consumed water to a set of one or more raw water sources, identifying a set of one or more marginal paths of water supply from each raw water source to the consumer, and quantifying the intensity of inputs associated with the marginal paths.Type: ApplicationFiled: August 9, 2021Publication date: January 11, 2024Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Meagan Mauter, Yang Liu
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Publication number: 20240009234Abstract: Provided herein are chimeric transmembrane receptor polypeptides configured to oligomerize upon recognition of an extramembrane signal. The receptors include an extramembrane domain, a transmembrane domain, and an intramembrane domain configured to induce activation of one or more intramembrane signal pathways upon oligomerization of the receptor. The provided receptors are particularly useful for engineered cell therapies. Also provided are systems and host cells including the disclosed receptors, and methods for using the disclosed materials.Type: ApplicationFiled: July 28, 2021Publication date: January 11, 2024Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Lei S. Qi, Michael Chavez, Paul B. Finn
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Publication number: 20240013409Abstract: A method for multiple object tracking includes receiving, with a computing device, a point cloud dataset, detecting one or more objects in the point cloud dataset, each of the detected one or more objects defined by points of the point cloud dataset and a bounding box, querying one or more historical tracklets for historical tracklet states corresponding to each of the one or more detected objects, implementing a 4D encoding backbone comprising two branches: a first branch configured to compute per-point features for each of the one or more objects and the corresponding historical tracklet states, and a second branch configured to obtain 4D point features, concatenating the per-point features and the 4D point features, and predicting, with a decoder receiving the concatenated per-point features, current tracklet states for each of the one or more objects.Type: ApplicationFiled: May 26, 2023Publication date: January 11, 2024Applicants: Toyota Research Institute, Inc., Toyota Jidosha Kabushiki Kaisha, The Board of Trustees of the Leland Stanford Junior UniversityInventors: Colton Stearns, Jie Li, Rares A. Ambrus, Vitor Campagnolo Guizilini, Sergey Zakharov, Adrien D. Gaidon, Davis Rempe, Tolga Birdal, Leonidas J. Guibas
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Publication number: 20240000758Abstract: The present disclosure provides methods of increasing mitochondrial biogenesis, function, or both in a tissue of a subject by administering to the subject an amount of a 15-PGDH inhibitor effective to inhibit 15-PGDH activity and/or reduce 15-PGDH levels in the subject. The methods described herein are useful for treating diseases, disorders, or conditions associated with dysfunctional mitochondria and/or increased oxidative stress including mitochondrial diseases.Type: ApplicationFiled: October 22, 2021Publication date: January 4, 2024Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Helen M. BLAU, Adelaida Rosa PALLA, Meenakshi RAVICHANDRAN
