Abstract: A method and an apparatus for multiple, simultaneous synthesis of compounds. The apparatus includes a reaction block having a heating layer, a cooling layer, each of which may perform both functions, and a collection sump. A plurality of reaction tubes are supported in the reaction block in a matrix. Each reaction tube has a top outlet, a bottom outlet and a filter above the bottom outlet. Spool valves are located to control the bottom outlets of the reaction tubes. Obturators are provided to close the top outlets of the reaction tubes and to provide venting for the reaction tubes. The collection sump alternately may be equipped with individual collection tubes for each reaction tube. Each reaction tube is formed with a restrictive waist and protrusions arranged in a pattern between the waist and its bottom outlet to improve the mixing of the resinous solid supports by creating turbulence.

Abstract: An apparatus for multiple, simultaneous synthesis of compounds. The apparatus includes a reaction block having a heating layer, a cooling layer, each of which may perform both functions, and a collection sump. A plurality of reaction tubes are supported in the reaction block in a matrix. Each reaction tube has a top outlet, a bottom outlet and a filter above the bottom outlet. Spool valves are located to control the bottom outlets of the reaction tubes. Obturators are provided to close the top outlets of the reaction tubes and to provide venting for the reaction tubes. The collection sump alternately may be equipped with individual collection tubes for each reaction tube. Each reaction tube is formed with a restrictive waist and protrusions arranged in a pattern between the waist and its bottom outlet to improve the mixing of the resinous solid supports by creating turbulence. The restrictive waist limits the height of the vortex of solution during mixing and reaction to facilitate heating and refluxing.

Abstract: A dispenser for dispensing measured amounts of powder for use in automated sample handling. The dispenser includes a cylindrical housing having a central cavity with an axial opening into the cavity at one end of the housing and a relatively narrow passage from the cavity leading out of the cylindrical housing through a nozzle at the opposite end thereof. A powder containing vial is removably mounted on the cylindrical housing. A radial passage through the cylindrical housing connects the vial with the narrow passage to discharge powder out through the nozzle. The cylindrical housing is rotatable supported on a mount through which extends a driven shaft. The driven shaft includes a worm drive located in the relatively narrow passage. A drive belt is provided to oscillate the cylindrical housing and the powder reservoir.