Abstract: An exemplary imaging system is provided. The imaging system includes a light source configured to illuminate a plurality of spatially separated regions of a material structure producing a first illumination. A lens produces an image of the spatially separated regions. A lens array magnifies the spatially separated regions of the image. The lens array produces a mosaic image comprised of magnified subimages of each region spatially separated region. A camera sensor to record the image.
Type:
Application
Filed:
July 18, 2023
Publication date:
January 25, 2024
Applicants:
Trustees of Boston University, Massachusetts Institute of Technology
Inventors:
Thomas Bifano, Jerome Mertz, Marshall Ma, Devin Beaulieu
Abstract: An example microscope includes a pump laser for providing a first illumination to a sample. A laser array provides a second illumination to the sample. The laser array may include a plurality of laser elements, each providing oblique illuminations to the sample. An illumination collecting source collects the first illumination and the second illumination from the sample. The illumination collecting source may capture transient 3D refractive index (RI) variations in the sample due to the first illumination and second illumination.
Type:
Application
Filed:
January 23, 2023
Publication date:
January 18, 2024
Applicant:
Trustees of Boston University
Inventors:
Ji-Xin Cheng, Jian Zhao, Lei Tian, Alex Matlock
Abstract: A gradiometer includes a at least one magnet attached to a beam. The magnet moves in response to a magnetic force. A sensing element is configured to measure movement or deflection of the beam or magnet. The gradiometer is configured to determine a gradient of a magnetic field acting on the first magnet based on movement of the magnet. The gradiometer can further measure higher order gradients.
Type:
Grant
Filed:
February 21, 2023
Date of Patent:
January 16, 2024
Assignee:
Trustees of Boston University
Inventors:
Joshua Javor, David Bishop, David Campbell, Matthias Imboden
Abstract: The systems, methods, devices and kits disclosed herein be used to determine the presence and/or level a target analyte(s) in a biological sample, wherein the analyte(s) is associated with a pathogenic (e.g., a viral antigen or whole virus) or otherwise altered physiological condition (e.g., pregnancy). In certain embodiments, the systems, methods, devices and kits provide one or more improved properties relative to the RT-PCT and lateral flow antibody assays known in the art for the detection of SARS-CoV-2, including but not limited to, assay time, ease of use, risk of infection, accuracy, specificity, selectivity, limit of detection of the assay, quantitative detection and the effect of common interferents to the sensor output, cost, simplicity or a combination thereof.
Type:
Application
Filed:
July 16, 2021
Publication date:
January 11, 2024
Applicant:
TRUSTEES OF BOSTON UNIVERSITY
Inventors:
Karthika SANKAR, Scott SCHAUS, James GALAGAN, Catherine KLAPPERICH, John CONNOR, Mark GRINSTAFF, Keith HEARON
Abstract: Described is a decoder suitable for use with any communication or storage system. The described decoder has a modular decoder hardware architecture capable of implementing a noise guessing process and due to its dependency only on noise, the decoder design is independent of any encoder, thus making it a universal decoder. Hence, the decoder architecture described herein is agnostic to any coding scheme.
Type:
Grant
Filed:
April 8, 2021
Date of Patent:
January 9, 2024
Assignees:
Massachusetts Institute of
Technology, National University of Ireland Maynooth, Trustees of Boston University
Inventors:
Amit Solomon, Muriel Medard, Kenneth R. Duffy, Rabia Tugce Yazicigil Kirby, Vaibhav Bansal, Wei An
Abstract: Provided herein are systems for determining a stretch condition of a tissue and assessing the stiffness of the tissue. Also provided herein are methods for using the systems for measuring stiffness of a tissue, assessing the effect of an agent on a tissue, and identifying subjects having a disease or disorder associated with increased or decreased stiffness of a tissue.
Type:
Application
Filed:
June 16, 2023
Publication date:
December 21, 2023
Applicants:
Trustees of Boston University, Beth Israel Deaconess Medical Center, Inc.
Inventors:
Bela Suki, Jae Hun Kim, Joseph Hall, Ramaswamy Krishnan, Niccole Schaible
Abstract: Microscopic analysis of a sample includes a system using dark-field illumination. A mid-IR optical source generates a mid-infrared beam, which is directed onto the sample to induce a temperature change by absorption of the mid-infrared beam. A visible light source generates a light illuminating the sample on a substrate and creating a scattered field and a reflected field along a collection path of the system. A pupil mask is positioned along the collection path to block the reflected field while allowing the scattered field to pass therethrough. A camera is positioned at an end of the collection path to collect the scattered field and generate a dark-field image of the sample.
Type:
Application
Filed:
June 2, 2023
Publication date:
December 21, 2023
Applicant:
Trustees of Boston University
Inventors:
Ji-Xin Cheng, Celalettin Yurdakul, Haonan Zong, M. Selim Ünlü
Abstract: A bilayler metamaterial silencer allows substantial fluid through the apparatus, while mitigating the propagation of sound through the apparatus, and while providing a form factor that is significantly more compact than previously-known devices. Moreover, illustrative embodiments allow a designer to specify one or both of the frequency or frequencies at which the apparatus mitigates sound propagation, and/or the bandwidth around the frequency or frequencies at which the apparatus mitigates sound propagation.
Type:
Grant
Filed:
December 4, 2020
Date of Patent:
December 19, 2023
Assignee:
Trustees of Boston University
Inventors:
Xin Zhang, Reza Ghaffarivardavagh, Stephan Anderson
Abstract: A system for near-surface subsurface imaging for detecting and characterizing subsurface heterogeneities comprises a non-contact acoustic source that senses a plurality of acoustic waves that travel through a surface; an instrument that outputs probing electromagnetic signals through the surface that interact and are affected by scattered signals of the acoustic waves and further senses vibrational modes of a subsurface below the surface; an imaging device that dynamically generates a time sequence of images of properties of the acoustic waves and maps elastic wave fields of the acoustic waves; and a processor that analyzes dynamic multi-wave data of the images to quantify spatial variations in the mechanical and viscoelastic properties of the subsurface.
Type:
Grant
Filed:
October 10, 2019
Date of Patent:
December 12, 2023
Assignees:
The Trustees of Boston University, Massachusetts Institute of Technology
Inventors:
Stephen Brown, Thomas Szabo, Daniel R. Burns, Michael Fehler
Abstract: Disclosed is an assay for determining resistance in a target cell or tissue to a therapy associated with cellular stress using chemical microscopy and high-throughput single cell analysis to determine functional metabolic alteration, including determining metabolic reprogramming in a target cell or tissue to a therapy associated with cellular stress, and methods of using the assays.
Type:
Application
Filed:
May 15, 2023
Publication date:
November 30, 2023
Applicants:
Trustees of Boston University, Northwestern University
Abstract: Provided herein are antileishmanial compounds, compositions comprising the antileishmanial compounds, and use thereof.
Type:
Application
Filed:
May 25, 2023
Publication date:
November 30, 2023
Applicant:
TRUSTEES OF BOSTON UNIVERSITY
Inventors:
Scott E. SCHAUS, Lauren E. BROWN, Mark W. GRINSTAFF, Danielle M. FITZGERALD, Diana L. DIAZ, John A. KAVOURIS, Jair LAGE DE SIQUEIRA-NETO, James MCKERROW, Camila INDIANI DE OLIVEIRA
Abstract: The present disclosure generally relates to compositions and method for delivery, e.g., sustained delivery of active agents, and their use for the treatment of diseases or disorders.
Type:
Grant
Filed:
October 7, 2022
Date of Patent:
November 21, 2023
Assignees:
Trustees of Boston University, The General Hospital Corporation
Inventors:
Eric M. Bressler, Sarah Adams, Yolonda Colson, Mark W. Grinstaff, Wilson Wai Chun Wong
Abstract: Disclosed is a biogel nanosensor for detection of an analyte that includes an acryloyl or methacryloyl modified hydrogel and nucleic acid amplification reagents in picoliter or nanoliter volume in the form of microarray. Also disclosed are methods of making the disclosed biogel nanosensor, and methods of using the biogel nanosensors.
Type:
Grant
Filed:
May 9, 2022
Date of Patent:
November 14, 2023
Assignees:
Trustees of Boston University, Fraunhofer USA, Inc., FRAUNHOFER-Gesellschaft zur Foerderung der angewandten Forschung e. V.
Inventors:
Christine McBeth, Kirsten Borchers, Achim Weber, Daniel Zontar
Abstract: Disclosed are methods of treating viral disorders via the administration of an inducing agent and an anti-viral agent. In one embodiment, the inducing agent and the anti-viral agent are administered for about five days, and the anti-viral agent is subsequently administered without the inducing agent for an additional period of about sixteen days for a total cycle of about 21 days.
Abstract: Disclosed is a hormone electrochemical biosensor, e.g. an amperometric biosensor, for the detection of a hormone and measurement of the concentration of a hormone. The disclosed hormone biosensor comprises a hormone-catalyzing enzyme, such as KSDH1. Also described herein are systems comprising an amperometric biosensor, e.g., chronoamperometric biosensor and methods of using the chronoamperometric biosensor.
Type:
Grant
Filed:
April 30, 2022
Date of Patent:
October 31, 2023
Assignee:
Trustees of Boston University
Inventors:
James Galagan, Uros Kuzmanovic, Abdurrahman Addokhi
Abstract: The invention provides novel and versatile classes of riboregulators, including inter alia activating and repressing riboregulators, switches, and trigger and sink RNA, and methods of their use for detecting RNAs in a sample such as a well and in modulating protein synthesis and expression.
Type:
Grant
Filed:
September 16, 2021
Date of Patent:
October 17, 2023
Assignees:
President and Fellows of Harvard College, Trustees of Boston University
Inventors:
Alexander A. Green, Peng Yin, James J. Collins, Jongmin Kim
Abstract: The technology described herein is directed to compositions comprising components of multi-component CALs or CARs, e.g., a TCR recognition domain; and one or both of: (a) an intracellular signaling domain; and (b) a first-type protein interaction domain. Further provided herein are methods for treating or preventing an autoimmune disease, a transplant rejection, or graft versus host disease.
Type:
Application
Filed:
June 16, 2023
Publication date:
October 12, 2023
Applicants:
TRUSTEES OF BOSTON UNIVERSITY, THE GENERAL HOSPITAL CORPORATION
Inventors:
Mohammadreza PAKYARI, Wilson WONG, Atsushi OKUMA, Curtis CETRULO