Abstract: The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present invention provides a method of treating an immune and inflammatory disorders disorder by administering a composition comprising a therapeutically effective dosage of an ascaroside compound, or a mixture of ascaroside compounds, or a mixture containing at least one ascaroside.
Type:
Grant
Filed:
August 1, 2022
Date of Patent:
June 13, 2023
Assignees:
California Institute of Technology, Boyce Thompson Institute for Plant Research
Inventors:
Andrea Choe, Paul W. Sternberg, Frank C. Schroeder, Stephan H. Von Reuss
Abstract: One aspect of the present invention relates to a nucleic acid construct that includes a nucleic acid molecule that encodes FLAGELLIN-SENSING 3 (“FLS3”) protein; a 5? heterologous DNA promoter sequence; and a 3? terminator sequence, where the nucleic acid molecule, the DNA promoter sequence, and the terminator sequence are operatively coupled to permit transcription of the nucleic acid molecule. The present invention also relates to a method of imparting disease resistance to a plant. This method involves transforming a plant or a plant seed with a nucleic acid molecule that increases expression of an FLS3 protein, where said transforming is effective in imparting disease resistance to the transformed plant or to a transgenic plant produced from the transformed plant seed.
Type:
Grant
Filed:
July 8, 2015
Date of Patent:
February 11, 2020
Assignee:
BOYCE THOMPSON INSTITUTE FOR PLANT RESEARCH, INC.
Inventors:
Gregory B. Martin, Sarah R. Hind, Susan R. Strickler
Abstract: The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present invention provides a method of treating an immune and inflammatory disorders disorder by administering a composition comprising a therapeutically effective dosage of an ascaroside compound, or a mixture of ascaroside compounds, or a mixture containing at least one ascaroside.
Type:
Grant
Filed:
January 18, 2019
Date of Patent:
November 19, 2019
Assignees:
California Institute of Technology, Boyce Thompson Institute for Plant Research
Inventors:
Andrea Choe, Paul W. Sternberg, Frank C. Schroeder, Stephan H. Von Reuss
Abstract: The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present invention provides a method of treating an immune and inflammatory disorders disorder by administering a composition comprising a therapeutically effective dosage of an ascaroside compound, or a mixture of ascaroside compounds, or a mixture containing at least one ascaroside.
Type:
Grant
Filed:
December 6, 2017
Date of Patent:
January 22, 2019
Assignees:
California Institute of Technology, Boyce Thompson Institute for Plant Research
Inventors:
Andrea Choe, Paul W. Sternberg, Frank C. Schroeder, Stephan H. Von Reuss
Abstract: The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present invention provides a method of treating an immune and inflammatory disorders disorder by administering a composition comprising a therapeutically effective dosage of an ascaroside compound, or a mixture of ascaroside compounds, or a mixture containing at least one ascaroside.
Type:
Grant
Filed:
August 8, 2012
Date of Patent:
January 16, 2018
Assignees:
California Institute of Technology, Boyce Thompson Institute for Plant Research
Inventors:
Andrea Choe, Paul W. Sternberg, Frank C. Schroeder, Stephan H. Von Reuss
Abstract: The present invention relates to methods of modifying nematode behavior using certain isolated modulator compounds. Also disclosed are methods of promoting or inhibiting reproduction in a nematode population, methods of promoting or inhibiting nematode aggregation at a first location, and methods of treating or preventing parasite infection of a plant.
Type:
Grant
Filed:
August 8, 2012
Date of Patent:
January 3, 2017
Assignees:
California Institute of Technology, Boyce Thompson Institute for Plant Research, The United States of America, As Represented by the Secretary of Agriculture
Inventors:
Andrea Choe, Paul W. Sternberg, Frank C. Schroeder, Stephan H. Von Reuss, Fatma Kaplan, Peter A. Teal, Hans Alborn
Abstract: The present invention relates to methods of modifying nematode behavior using certain isolated modulator compounds. Also disclosed are methods of promoting or inhibiting reproduction in a nematode population, methods of promoting or inhibiting nematode aggregation at a mammal, and methods of treating or preventing parasite infection of a mammal.
Type:
Grant
Filed:
August 8, 2012
Date of Patent:
November 8, 2016
Assignees:
California Institute of Technology, Boyce Thompson Institute for Plant Research, The Regents of the University of California
Inventors:
Andrea Choe, Paul W. Sternberg, Frank C. Schroeder, Stephan H. Von Reuss, Raffi V. Aroian
Abstract: Disclosed is an isolated nucleic acid molecule comprising a nucleotide sequence that is at least 90% identical to a nucleotide sequence encoding a protein having the amino acid sequence of SEQ ID NO 4, wherein the protein has an aspartic acid (Asp) at amino acid position 106 Transgenic plants comp?sing the nucleic acid have reduced or delayed softening and detenoration of fruit compared to wild-type plants Methods of genetic screening for plants having reduced or delayed softening and detenoration of fruit, isolated oligonucleotides, and a method of imparting to a plant the dfd trait are also disclosed.
Type:
Grant
Filed:
May 19, 2009
Date of Patent:
October 6, 2015
Assignees:
Cornell Research Foundation, Inc., Boyce Thompson Institute for Plant Research
Inventors:
Jocelyn Kenneth Rose, Tal Isaacson-Lustig, Julia Vrebalov
Abstract: The present invention relates to a nucleic acid construct having a nucleic acid molecule configured to silence ?-carotene hydroxylase expression, and host cells, expression systems, plants, and plant seeds having the nucleic acid construct. The present invention also relates to a method of enhancing beta-carotene content by growing a transgenic plant from a plant or seed transformed with the construct.
Type:
Grant
Filed:
December 19, 2005
Date of Patent:
August 25, 2015
Assignees:
Boyce Thompson Institute for Plant Research, The United States of America, as represented by the Secretary of Agriculture
Abstract: The present invention provides a method for restoring budding capability to GP64null baculoviruses including gp64null AcMNPV by expressing therein a portion of the VSV G protein gene or a truncated “stem” portion of the GP64 gene. Other embodiments provide methods to use portions of the G-stem or GP64 protein to target foreign proteins for display on virions.
Type:
Grant
Filed:
July 3, 2008
Date of Patent:
February 24, 2015
Assignee:
Boyce Thompson Institute for Plant Research
Abstract: The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present invention provides a method of treating an immune and inflammatory disorders disorder by administering a composition comprising a therapeutically effective dosage of an ascaroside compound, or a mixture of ascaroside compounds, or a mixture containing at least one ascaroside.
Type:
Application
Filed:
August 8, 2012
Publication date:
January 15, 2015
Applicants:
Boyce Thompson institute for Plant Research, California Institute of Technology
Inventors:
Andrea Choe, Paul W. Sternberg, Frank C. Schroeder