Abstract: Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA.
Type:
Application
Filed:
December 8, 2006
Publication date:
May 8, 2008
Applicant:
Bracco International B.V.
Inventors:
Philippe Bussat, Samir Cherkaoui, Hong (Helen) Fan, Bernard Lamy, Palaniappa Nanjappan, Radhakrishna Pillai, Sibylle Pochon, Bo Song, Rolf E. Swenson
Abstract: Novel metal-chelate complexes comprising aminocarboxylate ligands including substituted aromatic amide moieties, such as those having the formula wherein R13, A1, R1 and R2 are as defined herein, are disclosed.
Type:
Grant
Filed:
October 13, 2004
Date of Patent:
April 1, 2008
Assignee:
Bracco International B.V.
Inventors:
Radhakrishna K. Pillai, Sang I. Kang, Edmund R. Marinelli, Ramachandran S. Ranganathan, Michael F. Tweedle
Abstract: The invention is directed to injectable suspensions of gas-filled microvesicles, as well as methods of preparing and using the same, especially as ultrasound contrast agents.
Type:
Application
Filed:
September 7, 2007
Publication date:
March 13, 2008
Applicant:
Bracco International B.V.
Inventors:
Michel Schneider, Feng Yan, David Lazarus, Jean Brochot, Jerome Puginier
Abstract: A gasket 7 used for a prefilled syringe 1 in which liquid 3 is filled, having a constriction 8 on its circumferential side face in contact with an inner surface of a syringe barrel 2 and having a bottom face 7c which is not in contact with the liquid 3 whose circumference is formed in a tapered shape.
Type:
Application
Filed:
October 23, 2007
Publication date:
February 28, 2008
Applicants:
BRACCO INTERNATIONAL B.V., DAIKYO SEIKO, LTD.
Abstract: Method for preparing a lyophilized matrix and, upon reconstitution of the same, a respective injectable contrast agent comprising a liquid aqueous suspension of gas-filled microbubbles stabilized predominantly by a phospholipid and comprising a ligand agent. The method comprises preparing an emulsion from an aqueous medium, comprising a phospholipid and a water immiscible organic solvent. A suspension of a compound comprising the ligand agent or a precursor thereof is then added to emulsion. The emulsion is then freeze-dried and subsequently reconstituted in an aqueous suspension of gas-filled microbubbles.
Abstract: The invention provides compositions and methods for therapeutic and diagnostic applications.
Type:
Grant
Filed:
March 3, 2003
Date of Patent:
May 1, 2007
Assignees:
Bracco International B.V., Dyax Corp
Inventors:
Christophe Arbogast, Philippe Bussat, Hong Fan, Karen E. Linder, Edmund R. Marinelli, Palaniappa Nanjappan, Adrian Nunn, Radhakrishna Pillai, Sybille Pochon, Kondareddiar Ramalingam, Ajay Shrivastava, Bo Song, Rolf E. Swenson, Mathew A. Von Wronski, Aaron Sato, Sharon Michele Walker, Daniel T. Dransfield
Abstract: The invention provides radiopharmaceuticals for diagnostic and therapeutic applications, conjugates of antioxidants with metal chelating ligands, intermediate compounds, methods of making such radiopharmaceuticals, ligands, and intermediate compounds, and kits for preparing the radiopharmaceutical complexes.
Type:
Application
Filed:
November 20, 2006
Publication date:
April 19, 2007
Applicant:
BRACCO INTERNATIONAL B.V.
Inventors:
Ramachandran Ranganathan, Hong Fan, Michael Tweedle, Rolf Swenson
Abstract: Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the ?, ?, or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, and in one embodiment, a chemotherapeutic agent.
Type:
Application
Filed:
September 25, 2006
Publication date:
April 5, 2007
Applicant:
Bracco International B.V.
Inventors:
Paul Wedeking, Ruth Wager, Thangavel Arunachalam, Kondareddiar Ramalingam, Karen Linder, Ramachandran Ranganathan, Adrian Nunn, Nataranjan Raju, Michael Tweedle
Abstract: Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the ?, ?, or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, and in one embodiment, a chemotherapeutic agent.
Type:
Grant
Filed:
December 30, 2000
Date of Patent:
March 6, 2007
Assignee:
Bracco International B.V.
Inventors:
Paul W. Wedeking, Ruth E. Wager, Thangavel Arunachalam, Kondareddiar Ramalingam, Karen E. Linder, Ramachandran S. Ranganathan, Adrian D. Nunn, Natarajan Raju, Michael F. Tweedle
Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain surfactants and, optionally, hydrophilic stabilizers. The surfactants can be in the form of liposomes. The suspensions are obtained by exposing the surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003. Contrast agents with particular mixtures of gases are also disclosed that have advantageous properties.
Type:
Application
Filed:
June 1, 2006
Publication date:
November 16, 2006
Applicant:
Bracco International B.V.
Inventors:
Michel Schneider, Feng Yan, Nadine Garcel, Pascal Grenier, Jerome Puginier, Marie-Bernadette Barrau, Philippe Bussat, Eva Hybl, Daniel Bichon
Abstract: The present invention provides compounds for targeting endothelial cells, tumor cells or other cells that express the NP-1 receptor, compositions containing the same and methods for their use. Additionally, the present invention includes diagnostic, therapeutic and radiotherapeutic compositions useful for visualization, therapy or radiotherapy.
Type:
Grant
Filed:
June 4, 2001
Date of Patent:
September 19, 2006
Assignee:
Bracco International B.V.
Inventors:
Mathew A. Von Wronski, Edmund R. Marinelli, Adrian D. Nunn, Radhakrishna Pillai, Kondareddiar Ramalingam, Michael F. Tweedle, Karen Linder, Palaniappa Nanjappan, Natarajan Raju
Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain surfactants and, optionally, hydrophilic stabilizers. The surfactants can be in the form of liposomes. The suspensions are obtained by exposing the surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003. Contrast agents with particular mixtures of gases are also disclosed that have advantageous properties.
Type:
Grant
Filed:
March 12, 2003
Date of Patent:
August 1, 2006
Assignee:
Bracco International B.V.
Inventors:
Michel Schneider, Feng Yan, Nadine Garcel, legal representative, Jerome Puginier, Marie-Bernadette Barrau, Philippe Bussat, Eva Hybl, Daniel Bichon, Pascal Grenier, deceased
Abstract: The present invention provides compounds for targeting endothelial cells, tumor cells or other cells that express the NP-1 receptor, compositions containing the same and methods for their use. Additionally, the present invention includes diagnostic, therapeutic and radiotherapeutic compositions useful for visualization, therapy or radiotherapy.
Type:
Application
Filed:
January 27, 2006
Publication date:
July 13, 2006
Applicant:
Bracco International B.V.
Inventors:
Mathew Von Wronski, Edmund Marinelli, Adrian Nunn, Radhakrishna Pillai, Kondareddiar Ramalingam, Michael Tweedle, Karen Linder, Palaniappa Nanjappan, Natarajan Raju
Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase.
Type:
Grant
Filed:
July 15, 1997
Date of Patent:
April 25, 2006
Assignee:
Bracco International B.V.
Inventors:
Michel Schneider, Daniel Bichon, Philippe Bussat, Jerone Puginier, Eva Hybl
Abstract: Injectable aqueous suspension of microbubbles filled with a biocompatible gas and a method of preparation thereof. At least 10% of the total volume of gas contained in the microbubbles is contained in microbububbles with a diameter of 1.5 ?m or less. The microbubbles can be obtained by preparing an emulsion comprising an aqueous medium, a phospholipid and a water immiscible organic solvent. The emulsion is then freeze-dried and then reconstituted in an aqueous suspension of gas-filled microbubbles.
Type:
Application
Filed:
August 11, 2005
Publication date:
February 16, 2006
Applicant:
Bracco International B.V.
Inventors:
Michel Schneider, Philippe Bussat, Feng Yan, Christian Guillot
Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003.
Type:
Grant
Filed:
April 12, 2002
Date of Patent:
January 24, 2006
Assignee:
Bracco International B.V.
Inventors:
Michel Schneider, Feng Yan, Nadine Gercel, legal representative, Jerome Puginier, Maria-Bernadette Barrau, Philippe Bussat, Eva Hybl, Daniel Bichon, Pascal Grenier, deceased
Abstract: Novel methods, processes and metal complexes attached to a hypoxia-localizing moiety comprising a metal, preferably radionuclide of rhenium or technetium; a hypoxia-localizing moiety; and, a complexing ligand, wherein said ligand and said radionuclide combined have cell membrane permeabilities greater than that of sucrose, are disclosed.
Type:
Grant
Filed:
December 19, 2003
Date of Patent:
October 25, 2005
Assignee:
Bracco International B.V.
Inventors:
Karen Linder, Adrian D. Nunn, David P. Nowotnik, Kondareddiar Ramalingam, Richard J. DiRocco, William L. Rumsey, John P. Pirro
Abstract: One can impart outstanding resistance against collapse under pressure to gas-filled microvesicle used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003.
Type:
Grant
Filed:
July 15, 1998
Date of Patent:
June 27, 2006
Assignee:
Bracco International B.V.
Inventors:
Michel Schneider, Feng Yan, Nadine Garcel, Jerome Puginier, Marie-Bernadette Barrau, Philippe Bussat, Eva Hybl, Daniel Bichon, Pascal Grenier