Patents Assigned to Bracco Research USA
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Patent number: 6264916Abstract: Compounds having formulae I, II or/III, or pharmaceutically acceptable salts thereof, R1, R2, R3, R4, R5, R6, R7 and R8 are the same or different and are hydrogen, alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted aryl, haloalkyl, hydroxyalkyl, alkoxyalkyl, carboxyalkyl or carboxamido alkyl with the proviso that in formula I R2 and R3 cannot be methyl; and m, n and p are the same or different and are 0-24 with the proviso that m+n≦24, are useful as contrast agents in x-ray imaging compositions and methods.Type: GrantFiled: January 18, 2000Date of Patent: July 24, 2001Assignee: Bracco Research, USAInventors: Rama S. Ranganathan, Thangavel Arunachalam, Michael F. Tweedle
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Patent number: 6221334Abstract: Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the &agr;, &ggr;, or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, and in one embodiment, a chemotherapeutic agent.Type: GrantFiled: January 3, 2000Date of Patent: April 24, 2001Assignee: Bracco Research USA, Inc.Inventors: Paul W. Wedeking, Ruth E. Wager, Thangavel Arunachalam, Kondareddiar Ramalingam, Karen E. Linder, Ramachandran S. Ranganathan, Adrian D. Nunn, Natarajan Raju, Michael F. Tweedle
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Patent number: 6186997Abstract: Multiple use universal connector designed for use in various containers having a fluid port for accessing to the content of the container or for transferring fluid into the container. The multiple use universal connector incorporates a diaphragm capable of being penetrated repeatedly by an access means such as a luer connector or a syringe having a sharp or blunt cannula for fluid communication between the content of the container and the access means. The multiple use universal connector re-seals itself after being penetrated and the access means removed therefrom.Type: GrantFiled: July 20, 1998Date of Patent: February 13, 2001Assignee: Bracco Research USAInventors: Mark E. Gabbard, John J. Niedospial, Jr., Timothy J. Gabbard
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Patent number: 6179822Abstract: Single use universal connector, flexible medical container assembly for the containment and delivery of medical fluid having three access means: a single use universal connector access means for luer connection, needle or spike piercing; a needle access means and a spike access means.Type: GrantFiled: February 8, 1999Date of Patent: January 30, 2001Assignee: Bracco Research USAInventor: John J. Niedospial, Jr.
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Patent number: 6179823Abstract: Multiple use universal connector designed for use in various containers having a fluid port for accessing to the content of the container or for transferring fluid into the container. The multiple use universal connector incorporates a diaphragm capable of being penetrated repeatedly by an access means such as a luer connector or a syringe having a sharp or blunt cannula for fluid communication between the content of the container and the access means. The multiple use universal connector re-seals itself after being penetrated and the access means removed therefrom.Type: GrantFiled: February 8, 1999Date of Patent: January 30, 2001Assignee: Bracco Research USAInventor: John J. Niedospial, Jr.
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Patent number: 6156025Abstract: A twist valve for use in a fluid delivery system is provided for selectively allowing fluid flow and blocking fluid flow therethrough. The twist valve is in communication with a pre-filled flexible container and includes a proximal part and a distal part each having a fluid inlet and a fluid outlet. The proximal and distal parts are equipped with cylindrical helical surfaces which allow them to move toward or away from each other when a twisting force is applied to them. The fluid outlet of the proximal part is blocked with a stopper in the distal part when the twist valve is in the closed position, and is unblocked by the stopper when the twist valve is in the open position.Type: GrantFiled: June 17, 1999Date of Patent: December 5, 2000Assignee: Bracco Research USA Inc.Inventors: John J. Niedospial, Jr., Charles Quirico
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Patent number: 6105230Abstract: Method and apparatus for removing an elastomeric closure from the tapered tip of a pre-filled syringe or cartridge barrel stoppered at its open end by a slidable plunger; measuring the removal force required to remove the elastomeric closure from the tapered tip of the barrel; and subsequently measuring the breakaway and running forces required to move the plunger from its initial position toward the distal end of the syringe or cartridge barrel.Type: GrantFiled: February 27, 1999Date of Patent: August 22, 2000Assignee: Bracco Research USAInventor: Ernest Balestracci
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Patent number: 6093382Abstract: Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the .alpha., .gamma., or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, and in one embodiment, a chemotherapeutic agent.Type: GrantFiled: May 16, 1998Date of Patent: July 25, 2000Assignee: Bracco Research USA Inc.Inventors: Paul W. Wedeking, Ruth E. Wager, Thangavel Arunachalam, Kondareddiar Ramalingam, Karen E. Linder, Ramachandran S. Ranganathan, Adrian D. Nunn, Natarajan Raju, Michael F. Tweedle
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Patent number: 6056941Abstract: A kit containing a solution of boronic acid adducts of technetium-99 m dioxime complexes; and hydroxypropyl gamma cyclodextrin to maintain the solution free of particulate matter originating from the formulation.Type: GrantFiled: July 28, 1999Date of Patent: May 2, 2000Assignee: Bracco Research USAInventors: Ernest Schramm, Margaret Newborn, Julius P. Zodda, Thomas Katona, Jo Anna Monteferrante
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Patent number: 6051210Abstract: Compounds having formulae I, II or III, or pharmaceutically acceptable salts thereof, ##STR1## wherein ##STR2## R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are the same or different and are hydrogen, alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted aryl, haloalkyl, hydroxyalkyl, alkoxyalkyl, carboxyalkyl or carboxamido alkyl with the proviso that in formula I R.sub.2 and R.sub.3 cannot be methyl; andm, n and p are the same or different and are 0-24 with the proviso that m+n.ltoreq.24, are useful as contrast agents in x-ray imaging compositions and methods.Type: GrantFiled: March 22, 1999Date of Patent: April 18, 2000Assignee: Bracco Research USAInventors: Rama S. Ranganathan, Thangavel Arunachalam, Michael F. Tweedle
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Patent number: 6039718Abstract: Multiple use universal connector designed for use in various containers having a fluid port for accessing to the content of the container or for transferring fluid into the container. The multiple use universal connector incorporates a diaphragm capable of being penetrated repeatedly by an access means such as a luer connector or a syringe having a sharp or blunt cannula for fluid communication between the content of the container and the access means. The multiple use universal connector re-seals itself after being penetrated and the access means removed therefrom.Type: GrantFiled: February 9, 1999Date of Patent: March 21, 2000Assignee: Bracco Research USAInventor: John J. Niedospial, Jr.
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Patent number: 6019751Abstract: Universal connector designed for use in various containers having a fluid port for access to the content of the container or for transferring fluid into the container. The universal connector incorporates an elastomeric membrane capable of being ruptured by an access means such as a luer connector or a syringe having a sharp or blunt cannula for fluid communication between the content of the container and the access means.Type: GrantFiled: January 20, 1998Date of Patent: February 1, 2000Assignee: Bracco Research USAInventors: Mark E. Gabbard, John J. Niedospial, Jr., Timothy J. Gabbard
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Patent number: 5941866Abstract: A unitary, flexible container, for containment and delivery of medical fluids, having:a) first and second polymeric sheets superimposed and sealed together at their periphery defining an interior reservoir, the container having a top portion, a mid portion and a bottom portion; the bottom portion terminates in a first angle and a second angle of from about 5.degree. to about 45.degree. each from the center of the bottom portion to a horizontal plane crossing the center of the bottom portion;b) an access member integral with the unitary, flexible container located at the center of the bottom portion allowing filling the flexible container with medical fluids and access to the medical fluids for delivery to a patient; andc) at least one oval shaped rigid reinforcing disc positioned in the mid portion of the interior reservoir to prevent collapse of the walls of the container on each other causing hold up of droplets.Type: GrantFiled: July 25, 1997Date of Patent: August 24, 1999Assignee: Bracco Research USAInventor: John J. Niedospial, Jr.
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Patent number: 5921419Abstract: Universal closure assembly designed for use in various containers having a fluid port for access to the content of the container. The universal closure assembly incorporates an elastomeric membrane capable of being ruptured by an access means such as a luer connector or a syringe having a sharp or blunt cannula or a sharp or blunt spike for fluid cormunication between the content of the container and the access means.Type: GrantFiled: May 4, 1998Date of Patent: July 13, 1999Assignee: Bracco Research USAInventors: John J. Niedospial, Jr., Mark E. Gabbard, Timothy J. Gabbard
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Patent number: 5902298Abstract: A closure assembly/container combination for delivering media fluid to a patient by needleless access means. The closure assembly comprises an elastomeric stopper for sealing the container at its open end and a spike access means equipped with a luer connector.Type: GrantFiled: November 7, 1997Date of Patent: May 11, 1999Assignee: Bracco Research USAInventors: John J. Niedospial, Jr., Mark E. Gabbard
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Patent number: 5896989Abstract: Flexible medical container containing a light-sensitive medical fluid packaged in an overwrap having UV rays barrier properties to prevent degradation of the light-sensitive fluid but allowing observation of the content of the medical fluid and identifying inscription printed on the medical container.Type: GrantFiled: February 20, 1998Date of Patent: April 27, 1999Assignee: Bracco Research USAInventors: Irene K. Ropiak, John J. Niedospial, Jr., Michelle L. Robinson
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Patent number: D437050Type: GrantFiled: March 22, 1999Date of Patent: January 30, 2001Assignee: Bracco Research USAInventor: Ernest Balestracci
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Patent number: D422357Type: GrantFiled: May 4, 1998Date of Patent: April 4, 2000Assignee: Bracco Research USAInventors: John J. Niedospial, Jr., Mark E. Gabbard, Timothy J. Gabbard
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Patent number: D427676Type: GrantFiled: March 22, 1999Date of Patent: July 4, 2000Assignee: Bracco Research, USAInventor: Ernest Balestracci
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Patent number: D434850Type: GrantFiled: January 15, 1999Date of Patent: December 5, 2000Assignee: Bracco Research,USAInventor: Ernest Balestracci