Abstract: In a dispense tip adapter system, an adapter unit provides for compatibility between high-performance dispensing needles and conventional dispensing pump systems. The dispensing pump includes an outlet through which dispensed material is delivered, and includes an output body with alignment pins extending therefrom and first threads about the body. The dispensing needle includes a longitudinally-disposed body and neck, the body and neck including a longitudinal port providing a path for delivery of the dispensed material through the dispensing needle. The body of the dispensing needle includes an outer surface that is keyed for angular positioning of the needle with respect to the pump. The adapter includes an alignment plate, and index plate and an adapter nut. The alignment plate comprises a plurality of alignment holes for mating with the alignment pins, a material aperture aligned with the pump outlet, and a plurality of index pins extending from the body of the alignment plate.