Patents Assigned to Brigham & Woman's Hospital
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Patent number: 11702403Abstract: Disclosed are compounds that activate excitatory amino acid transporter 2 (EAAT2), as well as methods of using these compounds to treat or preventing diseases, disorders, and conditions associated with glutamate excitotoxicity.Type: GrantFiled: June 4, 2019Date of Patent: July 18, 2023Assignees: OHIO STATE INNOVATION FOUNDATION, THE BRIGHAM AND WOMAN'S HOSPITAL, INC.Inventors: Kevin Hodgetts, Chien-Liang Glenn Lin
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Publication number: 20230136997Abstract: The present invention is directed to methods and compositions for treating Glioblastoma multiforme (GBM). The risk of developing therapy resistant GBM may be assessed by detecting the presence of ABCB5 in the GBM cells. Therapeutic interventions utilizing an ABCB5 blockade to sensitize the GBM cells to therapeutic agents such as temozolomide are provided.Type: ApplicationFiled: April 14, 2021Publication date: May 4, 2023Applicants: Children's Medical Center Corporation, The Brigham and Woman's Hospital, Inc.Inventors: Markus H. Frank, Natasha Y. Frank
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Publication number: 20230123669Abstract: The present disclosure provides a novel machine learning model capable of assisting those of ordinary skill in the art to conduct base editing by, inter alia, facilitating the selection of an appropriate guide RNA and base editor combination which are capable of conducting base editing at a certain level of efficiency and specificity on a given input target DNA sequence desired to be edited to produce an outcome genotype of interest. The disclosure also provides base editors (e.g., ABEs and CBEs), napDNAbps, cytidine deaminases, adenosine deaminases, nucleic acid sequences encoding base editors and components thereof, vectors, and cells. In addition, the disclosure provides methods of making biological or experimental training and/or validation data for training and/or validating the machine learning computational models, as well as, vectors, libraries, and nucleic acid sequences for use in obtaining said experimental training and/or validation data.Type: ApplicationFiled: February 5, 2021Publication date: April 20, 2023Applicants: The Broad Institute, Inc., President and Fellows of Harvard College, Massachusetts Institute of Technology, The Brigham and Woman's Hospital, Inc.Inventors: David R. Liu, Mandana Arbab, Max Walt Shen, Christopher Cassa
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Publication number: 20220080115Abstract: Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject).Type: ApplicationFiled: May 17, 2018Publication date: March 17, 2022Applicants: Massachusetts Institute of Technology, The Brigham and Woman's Hospital, Inc.Inventors: Carlo Giovanni Traverso, Alex G. Abramson, Ester Caffarel Salvador, Niclas Roxhed, Minsoo Khang, Taylor Bensel, Robert S. Langer
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Patent number: 9719992Abstract: The present disclosure provides, inter alia, genetically encoded recombinant peptide biosensors comprising analyte-binding framework portions and signaling portions, wherein the signaling portions are present within the framework portions at sites or amino acid positions that undergo a conformational change upon interaction of the framework portion with an analyte.Type: GrantFiled: August 8, 2012Date of Patent: August 1, 2017Assignees: Howard Hughes Medical Institute, Brigham & Woman's Hospital, Inc.Inventors: Jonathan Marvin, Loren Looger, Richard T. Lee, Eric Schreiter
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Patent number: 8912314Abstract: The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to poly-N-acetyl glucosamine (PNAG), such as Staphylococcal PNAG, in acetylated, partially acetylated and/or fully deacetylated form. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of infections by bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Some antibodies of the invention enhance opsonophagocytic killing and in vivo protection against bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.Type: GrantFiled: January 7, 2013Date of Patent: December 16, 2014Assignees: The Brigham and Woman's Hospital, Inc., Beth Israel Deaconess Medical Center, Inc.Inventors: Gerald B. Pier, Casie Anne Kelly-Quintos, Lisa Cavacini, Marshall R. Posner
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Patent number: 8660634Abstract: A system and method for producing a more accurate ventilation image, as compared to existing lung Fourier decomposition methods, and an image of ventilation dependent blood volume are provided. A time series of images depicting a subject's lungs during free-breathing are acquired and co-registered to a reference image. From the registration process, geometric information indicative proton density changes due to inhalation and exhalation of gas is obtained. This geometric information is used to correct the proton density values in the time series of image frames. These corrected proton density values are Fourier transformed to produce a Fourier spectrum, from which a signal peak occurring at the breathing frequency is extracted and Fourier transformed to produce a more accurate ventilation image. This more accurate ventilation image can be subtracted from a breathing frequency image produced by conventional lung Fourier decomposition methods to produce a ventilation dependent blood volume image.Type: GrantFiled: April 23, 2012Date of Patent: February 25, 2014Assignee: The Brigham and Woman's HospitalInventors: Samuel Patz, James P Butler
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Patent number: 8524453Abstract: This invention is related, in part, to assays for analyzing the lectin complement pathway (LCP) as well as to compositions and methods related thereto.Type: GrantFiled: February 9, 2007Date of Patent: September 3, 2013Assignee: The Brigham and Woman's Hospital, Inc.Inventors: Gregory L. Stahl, Mary C. Walsh
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Patent number: 7803602Abstract: The present invention is directed to methods for producing and selecting new mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; compositions directed to the new mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; improved methods for purification of individual capsular polysaccharides; and compositions directed to new res02 and inv19 genes and their gene products. Significantly, the present invention provides methods and compositions for overexpressing and purifying immunomodulatory capsular polysaccharide A (PSA) in high yield.Type: GrantFiled: August 20, 2007Date of Patent: September 28, 2010Assignee: The Brigham and Woman's Hospital, Inc.Inventors: Laurie E. Comstock, Katja G. Weinacht, Michael J. Coyne, Dennis L. Kasper, Arthur O. Tzianabos
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Patent number: 7737178Abstract: Aspirin triggered lipid mediators (ATLMs) are disclosed which are useful for the treatment of prevention of inflammation associated with various diseases, including ischemia.Type: GrantFiled: December 18, 2008Date of Patent: June 15, 2010Assignee: The Brigham and Woman's Hospital, Inc.Inventors: Charles N. Serhan, Clary B. Clish
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Patent number: 7067129Abstract: The present invention relates in general to methods and products for initiating an immune response against an antigen, and in particular relates to transepithelial delivery of antigens to provoke tolerance and immunity. The present invention further relates to methods and products for the transepithelial delivery of therapeutics. In particular, the invention relates to methods and compositions for the delivery of therapeutics conjugated to a FcRn binding partner to intestinal epithelium, mucosal epithelium and epithelium of the lung. The present invention further relates to the synthesis, preparation and use of the FcRn binding partner conjugates as, or in, pharmaceutical compositions for oral systemic delivery of drugs and vaccines.Type: GrantFiled: August 8, 2002Date of Patent: June 27, 2006Assignees: The Brigham and Woman's Hospital, Inc., Brandeis UniversityInventors: Richard S. Blumberg, Neil E. Simister, Wayne I. Lencer
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Publication number: 20020094975Abstract: Methods and compositions of tricyclic antidepressants for inducing local long-lasting anesthesia and analgesia are provided. The methods and compositions are useful for alleviating acute and chronic pain, particularly useful for treating a localized pain.Type: ApplicationFiled: September 26, 2001Publication date: July 18, 2002Applicant: The Brigham and Woman's Hospital, Inc.Inventors: Ging Kuo Wang, Peter Gerner
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Patent number: 6410335Abstract: Methods of predicting a propensity to developing prostate cancer are presented. The consists of measuring the IGF status of individual. Individuals with high IGF status, as compared with normal reference range values, are at increased risk for developing prostate cancer. More particularly, the IGF status may be determined by measuring IGF-I levels and/or IGFBP-3 levels. High IGF and low IGFBP levels are indicative of a high IGF status. A method of determining the prognosis of existing prostate cancers or of monitoring disease progression involves determining the IGF/PSA status of an individual. Individuals with a high IGF/PSA staus (both high IGF status and high PSA levels) tend to develop severe prostate cancer and have a porrer overall prognosis.Type: GrantFiled: January 21, 1999Date of Patent: June 25, 2002Assignees: The Brigham and Woman's Hospital, Inc., Sir Mortimer B. Davis - Jewish General Hospital FoundationInventors: Michael N. Pollak, Meir J. Stampfer, Edward Giovannucci
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Patent number: 6218510Abstract: Structural forms of T cell costimulatory B7-1 and B7-2 molecules are described. These structural forms comprise a structural domain or have a structural domain deleted or added. The structural forms correspond to naturally-occurring alternatively spliced forms of T cell costimulatory molecules or variants thereof which can be produced by standard recombinant DNA techniques. In one embodiment, the T cell costimulatory molecule of the invention contains a cytoplasmic domain. In another embodiment, the T cell costimulatory molecule of the invention contains a signal peptide domain or has an immunoglobulin variable region-like domain deleted. The structural forms of T cell costimulatory molecules can be used to identify agents which stimulate the expression of alternative forms of costimulatory molecules and to identify components of the signal transduction pathway which results in costimulation of T cells.Type: GrantFiled: March 2, 1994Date of Patent: April 17, 2001Assignees: Brigham & Woman's Hospital, Dana-Farber Cancer InstituteInventors: Arlene H. Sharpe, Francescopaolo Borriello, Gordon J. Freeman, Lee M. Nadler
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Patent number: 5574068Abstract: S-nitrosothiols exert a potent relaxant effect, mediated both by guanylate cyclase, and a cGMP-independent mechanism, upon non-vascular smooth muscle. Such types of smooth muscle include airway, gastrointestinal, bladder, uterine and corpus cavernosal. Thus, S-nitrosothiols may be used for the treatment or prevention of disorders associated with relation of smooth muscle, such as airway obstruction, and other respiratory disorders, bladder dysfunction, premature labor and impotence. Additionally, S-nitrosothiols may be used to alleviate smooth muscle contraction and spasm, and thus facilitate procedures involving diagnostic instrumentation, such as endoscopy, bronchoscopy, laparoscopy and cystoscopy. S-nitrosothiols also increase the binding affinity between hemoglobin and oxygen, and therefore, may be used to improve hemoglobin-oxygen binding, and oxygen transport to bodily tissues.Type: GrantFiled: November 14, 1994Date of Patent: November 12, 1996Assignee: Brigham and Woman's HospitalInventors: Jonathan Stamler, Joeseph Loscalzo, Adam Slivka, Daniel Simon, Robert Brown, Jeffrey Drazen