Abstract: A method for loading an assembly for a CAx client includes determining referenced part IDs referenced by the assembly and for each referenced part ID, determining a latest applied command of saved checkpoints for each part file of a referenced part ID. The method further includes determining any unapplied commands for each referenced part ID, loading the part file for each referenced part ID with the latest applied command to the CAx client, and applying the unapplied commands sequentially by command number. A computer program product such as a computer readable medium and a computer system corresponding to the above method are also disclosed herein.

Abstract: An apparatus, method, and program product are disclosed for collaborative project modification. One apparatus includes an enabling module that enables a first group of users to modify a first portion of a project in a collaborative environment. The apparatus includes a blocking module that blocks a second portion of the project from being modified by the first group of users. The apparatus includes an updating module that, for the first group of users, conducts immediate updates to the first portion of the project after a user of the first group of users modifies the first portion of the project and conducts deferred updates to the second portion of the project after a user of a second group of users modifies the second portion of the project.

Abstract: A method and system for recycling signals in a leaky mode device for a holographic display or other application. A leaky mode device comprises at least a first transducer, a substrate, and a second transducer. The first transducer may be configured to receive an input signal from a signal arbiter, which forwards to the first transducer as an input signal either a new input signal or a recycled input signal (or some combination of the two). The first transducer converts the received input signal to a SAW (surface acoustic wave) and transmits the SAW through the substrate to the second transducer, which converts the received SAW to an output signal, and forwards the output signal to an amplifier, which amplifies the output signal (now a “recycled” signal) and forwards to the signal arbiter. This system facilitates persistence for points in a holographic display without the need for continually rewriting to leaky mode devices.

Abstract: A computer-implemented method for preventing reference invalidation when reversing operations in synchronous collaborative applications may include (i) storing, on a client, a shared model of an engineering object including one or more features, (ii) receiving, from a user, an operation to be performed on the feature, (iii) before performing the operation, storing, in a command stack on the client, information sufficient to restore the feature to a state prior to performing the operation, (iv) receiving, from the user, a request to reverse the operation, (v) determining whether reversing the operation will create an invalid reference due to a conflicting operation having been performed on the feature at a second client, and (vi) in response to determining whether reversing the operation will create an invalid reference, reversing the operation or performing a resolution operation to prevent the reference invalidation. A system corresponding to the above method is also disclosed.

Abstract: Described herein are methods for evaluating the risk of preterm birth in pregnant subjects. The methods involve detecting and quantifying one or more biomarkers associated with preterm birth in a biological sample from the subject. Also described herein are isolated biomarkers and kits useful in predicting the risk of preterm birth.

Abstract: The present invention provides a system and a method for detecting or determining possible fraudulent information provided by a subject using the subject's behavioral biometric during an application filing process using an electronic input device. The method involves comparing the subject's electronic input device usage characteristic with a control electronic input device usage characteristic data to determine a fraud potential of the subject's input or answer to the question.

Abstract: Techniques of refining a model of a complex surface can include deriving a set of refinement rules based on eigen polyhedra in a plane. Such rules reduce the refinement of a mesh in the plane to a scale and translation of the eigen polyhedron. Such refinement rules may then be applied to a non-uniform mesh in three-dimensional space having an extraordinary point in place of conventional refinement rules used in Catmull-Clark surfaces or NURBS surfaces. When these refinement rules are applied to a non-uniform mesh having an extraordinary point, the limiting surface is G1 at the extraordinary point, i.e., the tangent surfaces of the limiting mesh are continuous at the extraordinary point.

Abstract: Disclosed herein are methods of treating fungal infections in a patient, comprising identifying a patient in need of treatment and administering a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Kits comprising such compositions and instructions on such methods are also contemplated herein.

Abstract: A method for collaborative CAx editing may include enabling a user to define a partitioning constraint for a design space and partitioning the design space into editing regions according to the partitioning constraint and assigning users to specific editing regions. The method may also include displaying a feature tree, enabling a user to select and lock a selected feature for editing by a specified user, enabling the specified user to edit the selected feature and blocking access from other users to the selected feature. An apparatus corresponding to the above method is also disclosed herein.

Abstract: The disclosure provides compounds, methods, and kits for diagnosis, detection, screening, and imaging of a disease condition (e.g., infection, cancer, tumor, neoplasia), in vitro, ex vivo, and/or in vivo. Certain embodiments include administering a cationic steroid antimicrobial (a “CSA” or “ceragenin”), the CSA including a steroidal backbone and a heterocyclic ring separated from the steroidal backbone by at least 4 atoms (and up to 24 atoms or more), to a subject having or at risk of having a disease condition in an amount effective to diagnose, detect, screen for or image the disease condition in the subject.

Abstract: This disclosure relates to dermal treatment compositions, such as dermal fillers and tissue glues, and injectable compositions that incorporate one or more cationic steroidal antimicrobials (CSAs). The CSAs are incorporated into the dermal treatment compositions to provide effective antimicrobial, anti-inflammatory, analgesic, anti-swelling and/or tissue-healing properties. A treatment composition includes a component formed from a biologically compatible material suitable for injection into and/or application onto tissue at a treatment site. One or more CSA compounds are mixed with the biologically compatible material so that the one or more CSA compounds are incorporated within the composition, forming a reservoir of CSA compounds within the resulting bolus of the treatment composition after injection and/or application.

Abstract: According to an aspect, a device may include a deployable rolling joint having a first deployable joint member, a second deployable joint member, and a plurality of flexures coupled to the first deployable joint member and the second deployable joint member. The deployable rolling joint may move from an undeployed state to a deployed state in which the first deployable joint member forms a convex surface portion and the second deployable joint member forms a convex surface portion. When the deployable rolling joint is in the deployed state, the convex surface portion of the first deployable joint member may roll with respect the convex surface portion of the second deployable joint member, and the plurality of flexures may hold the first deployable joint member and the second deployable joint member together as the first deployable joint member and the second deployable joint member roll across each other.

Abstract: Compositions and methods for preparing stabilized CSA compositions having reduced agglomeration and increased stability. The compositions have increased efficacy in killing microbes and reduced cytotoxicity to mammals. The compositions include a liquid carrier, micelles formed from an amphiphilic material, and CSA molecules encapsulated by the micelles. The CSA compositions can be formed by blending together a solvent or liquid carrier, a plurality of CSA molecules, and a micelle-forming agent and causing or allowing the micelle-forming agent to form micelles encapsulating at least a portion of the CSA molecules so that no more than 25% of the CSA molecules form agglomerates larger than 1 ?m in size. The CSA compositions can be used to treat mammals, such as mammals suffering from microbial diseases or infections.

Abstract: A hand to mouth bite counting device is provided that may be worn on a hand, wrist or arm of a user to silently and continuously count the number of bites of food taken by the user. The bite counting device may include a sensing device that collects data corresponding to a sensed movement, and a processor that implements an algorithm to process the collected data and determine whether data collected within a given interval of time corresponds to a bite of food taken by the user. The processor derives a set of attributes from the data collected within the given interval of time to define the sensed movement. The device also provides feedback, goal setting functionality, and long-term statistics to serve as a dietary aid.

Abstract: Fluid level measurements for the shared tank and outflow information provided by calibrated flow meters corresponding to dispensing stations connected to the shared tank may be used to derive a filled volume model for the tank as a function of fluid level. Subsequently, a filled volume change for a shared tank over a selected time interval may be determined from pre-change and post-change fluid level measurements. The change in filled volume may be compared with the total fluid flow over the selected time interval as indicated by the flow meters of active dispensing stations. If the filled volume change for the tank is substantially different than the total fluid flow indicated by the flow meters, the flow meters may be collectively adjusted to provide a more accurate indication of the filled volume change in the shared tank.

Abstract: The present disclosure relates to scaphopetalone analogs, methods of making the analogs, and their uses.

Abstract: Disclosed herein are methods of treating cancer and/or reducing cellular proliferation in a patient, comprising identifying a patient in need of treatment and administering a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Kits comprising such compositions and instructions on such methods are also contemplated herein.

Abstract: Systems and methods for dynamic display of hierarchical data (e.g., a tree) are provided. Dynamic display enables a user to navigate the hierarchical data by dragging, without having to select expand/contract icons. The systems and methods use a tree spacing structure to determine relative spacing of nodes based on a focus line and to automatically expand and collapse visual representations of nodes in the tree. Nodes on the focus line may be evenly spaced along the focus line, and all of the other nodes in the hierarchy not on the focus line may be positioned based on their relationship to nodes on the focus line, using the tree spacing structure. Ancestor nodes of nodes on the focus line may be positioned between their direct first and last child and children of focus level nodes may be positioned directly behind the focus level node.

Abstract: A method and system for using laser-induced structures to direct light to exit the bottom of a leaky mode device, and further to divide leaky mode light into multiple orders, and to implement one or more pulsing/strobing patterns such that a field of view is increased for a viewer, or the view zone is increased for a viewer. A leaky mode device may comprise a substrate, a surface acoustic wave (“SAW”) transducer, a waveguide having a higher refractive index than the substrate, an input region for input light, and laser induced structures such as grating. The SAW transducer may be positioned on a top surface of the substrate, and may be configured to emit a SAW wave to propagate across the substrate. The waveguide may be positioned below the SAW. The input wave region may be configured to couple light onto the waveguide.

Abstract: Prodrugs or pharmaceutically acceptable salts, stereoisomers, solvates, or polymorphs thereof include a pharmaceutically and/or diagnostically active cationic steroidal antimicrobial (hereinafter “CSA”) compound or pharmaceutically acceptable salt, stereoisomer, solvate, or polymorph thereof, and one or more cleavable groups (C.G.). Some embodiments include a CSA compound prepared in an inactive or less active form and that is capable of conversion to a fully active form upon administration to a subject, upon preparation of a pharmaceutical formulation containing the CSA composition, and/or upon exposure to physiological conditions. Pharmaceutical compositions include the prodrug or pharmaceutically acceptable salt, stereoisomer, solvate, or polymorph thereof and one or more pharmaceutically acceptable excipients.