Patents Assigned to British Technology Group Limited
  • Method for preparing 17-substituted steroids useful in cancer treatment
    Patent number: 5618807
    Abstract: Compounds of the general formula (1) ##STR1## wherein X represents the residue of the A, B and C rings of a asteroid, R represents a hydrogen atom or an alkyl group of 1 to 4 carbon atoms, R.sup.14 represents a hydrogen atom and R.sup.15 represents a hydrogen atom or an alkyl or alkoxy group of 1-4 carbon atoms, or a hydroxy or alkylcarbonyloxy group of 2 to 5 carbon atoms or R.sup.14 and R.sup.15 together represent a double bond, and R.sup.16 represents a hydrogen atom or an alkyl group of 1 to 4 carbon atoms, in the form of the free bases or pharmaceutically acceptable acid addition salts, are used for treatment of androgen-dependent disorders, especially prostatic cancer, and also oestrogen-dependent disorders such as breast cancer.
    Type: Grant
    Filed: February 22, 1995
    Date of Patent: April 8, 1997
    Assignee: British Technology Group Limited
    Inventors: Susan E. Barrie, Michael Jarman, Gerard A. Potter, Ian R. Hardcastle
  • Oligonucleotides and their use in an assay for encephalopathies
    Patent number: 5618673
    Abstract: Oligonucleotides of formula(X).sub.a -(6N-palindrome).sub.n -(Y).sub.b ( 1)wherein:"6N-palindrome" represents TACGTA, ACGTAT, CGTATA, GTATAC, TATACG or ATACGT (read in the conventional notation with the 5'-end at the left);n is an appropriate integer of at least 2;X is a length of appropriate 5'-end or tailing DNA and a is 0 or 1; andY is a length of appropriate 3'-end or heading DNA and b is 0 or 1;or any labelled form thereof or any derivative thereof which retains the ability of the 6N-palindrome sequence to anneal or hybridize to its complementary sequence are useful in assay of encephalopathies such as scrapie, BSE or CJD. Preferably they are used as PCR primers to amplify DNA in the sample. PCR product can be detected by restriction with an appropriate enzyme and comparing the restricted and unrestricted products.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 8, 1997
    Assignee: British Technology Group Limited
    Inventor: Harash K. Narang
  • Triazenyl-substituted phenyl pyrimidines and their use in therapy
    Patent number: 5618928
    Abstract: Compounds of formula I: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each independently hydrogen, alkyl or acyl, R.sup.5 is alkyl, X represents a hydrophobic substituent and n is an integer from 1 to 3, and R.sup.6 and R.sup.7 each represent alkyl, cycloalkyl, or aralkyl, or R.sup.6 and R.sup.7 together with the nitrogen to which they are attached form a heterocyclic ring, with the proviso that one or both of R.sup.6 and R.sup.7, or the heterocyclic ring including R.sup.6 and R.sup.7, carries and/or includes at least one oxygen or sulphur atom, or a salt or N-oxide thereof may be used in the treatment of P. carinii infections.
    Type: Grant
    Filed: January 13, 1995
    Date of Patent: April 8, 1997
    Assignee: British Technology Group Limited
    Inventors: Malcolm F. G. Stevens, Daniel L. Rathbone, Dennis M. O'Shea
  • Lectins for treatment of skin diseases
    Patent number: 5607679
    Abstract: Certain lectins, namely those which can bind a sialylated TF antigen, especially the mushroom lectin from Agaricus bisporus, are useful in the treatment of skin diseases such as psoriasis and benign keratoses. They may be formulated as, for example, creams, ointments, cosmetic lotions or shampoos.
    Type: Grant
    Filed: March 17, 1995
    Date of Patent: March 4, 1997
    Assignee: British Technology Group Limited
    Inventor: Jonathan M. Rhodes
  • Method of and apparatus for obtaining NMR information
    Patent number: 5608322
    Abstract: Spatial NMR information is obtained from a sample by applying a magnetic field having a static component and two orthogonal periodically-varying gradient components. A recurring cycle of rf excitation pulses is applied. One of the gradient components is reduced in amplitude from its maximum to zero over a period and the other gradient component is subsequently increased from zero to its maximum over a period. The said periods are both longer than the cycle time.
    Type: Grant
    Filed: June 2, 1994
    Date of Patent: March 4, 1997
    Assignee: British Technology Group Limited
    Inventors: Andrew R. Lonergan, Peter J. McDonald
  • Passive dust sampler and method of dust estimation
    Patent number: 5607497
    Abstract: A personal dust sampler hangs from a ribbon (10) attached to the user's clothing and requires no pump or power source. Dust in the air is captured by a charged PVC sheet (2) exposed at (2a) but framed by a metal foil (25) and surmounted by a metal conductor plate (6) parallel to the charged PVC sheet (2). The plate (6) is supported by conductive gridwork (3) removably attached by a flange (3) to a metal base (21). The dust captured is determined in a method by weighing or by measuring the charge loss of the PVC sheet (2).
    Type: Grant
    Filed: January 19, 1995
    Date of Patent: March 4, 1997
    Assignee: British Technology Group Limited
    Inventor: Richard C. Brown
  • Microprobe for surface-scanning microscopes
    Patent number: 5606162
    Abstract: The invention provides, for a surface-scanning microscope, a probe having comparable stiffness in respect of deflections in two different directions, namely the direction towards and away from the surface and a direction in a plane parallel to the surface. For that purpose the probe, which comprises a support body, a resilient arm or cantilever having one end supported by the support body and another, free, end having thereon a sharp tip or stylus, has its arm or cantilever meander-shape.The invention further provides a method making such a probe, having its support body and tip or stylus as integral parts, from a wafer of crystalline material by etching.
    Type: Grant
    Filed: July 1, 1996
    Date of Patent: February 25, 1997
    Assignee: British Technology Group Limited
    Inventors: Rudolf A. Buser, Juergen Brugger, Christian Linder
  • 17-substituted steroids useful in cancer treatment
    Patent number: 5604213
    Abstract: Compounds of the general formula (1) ##STR1## wherein X represents the residue of the A, B and C rings of a steroid, R represents a hydrogen atom or an alkyl group of 1 to 4 carbon atoms, R.sup.14 represents a hydrogen atom and R.sup.15 represents a hydrogen atom or an alkyl or alkoxy group of 1-4 carbon atoms, or a hydroxy or alkylcarbonyloxy group of 2 to 5 carbon atoms or R.sup.14 and R.sup.15 together represent a double bond, and R.sup.16 represents a hydrogen atom or an alkyl group of 1 to 4 carbon atoms, in the form of the free bases or phannaceutically acceptable acid addition salts, are useful for treatment of androgen-dependent disorders, especially prostatic cancer, and also oestrogen-dependent disorders such as breast cancer.
    Type: Grant
    Filed: September 30, 1994
    Date of Patent: February 18, 1997
    Assignee: British Technology Group Limited
    Inventors: Susan E. Barrie, Michael Jarman, Gerard A. Potter, Ian R. Hardcastle
  • Pharmaceutical carrier
    Patent number: 5603958
    Abstract: The invention refers to the use of an inert, structure-giving, deadjuvanated matrix of a complex of a sterol, such as cholesterol, and one or more saponins as a carrier for the administration of a pharmaceutically active substance, and a drug carrying particle comprising said inert structure-giving matrix to which has been connected a pharmaceutically active substance. The drug carrying particle, delpha, has an annular basic structure which can form spherical nano particles having a size of 30-50 nm and a narrow size distribution.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: February 18, 1997
    Assignee: British Technology Group Limited
    Inventors: Bror Morein, Karin L ovgren
  • Command-curable composition
    Patent number: 5601640
    Abstract: A light-curable dental cement composition contains (a) the reaction product of vinyl phosphonyl chloride and pentane 1,5 diol, (b) a photopolymerisation initiator, (c) ion-leachable aluminosilicate glass powder, (d) poly(vinyl phosphonic acid), (e) bisGMA as a photopolymerisable dimethacrylate resin, and water, inert filler and silanising agent. Upon mixing, glass is added last, the composition is put in place and, when ready, it is light-irradiated for 30 or 40 seconds to polymerise (e). The composition is immediately firm and the phosphonate groups adhere to tooth material while further slow curing by acid-base reaction continues.
    Type: Grant
    Filed: March 23, 1995
    Date of Patent: February 11, 1997
    Assignee: British Technology Group Limited
    Inventors: Helen M. Anstice, John W. Nicholson
  • Antifungal compounds
    Patent number: 5599847
    Abstract: Compounds having the formula (I) below:(R.sub.1 R.sub.2 N)CH.sub.2 --CH.dbd.CH--CH.sub.2 (NR.sub.3 R.sub.4)(I)wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which may be the same or different represent hydrogen atoms, an alkyl group having from 1 to 6 carbon atoms, a cycloalkyl group of 3 to 6 carbon atoms, a heterocyclic group, an aryl group, a heteroaryl group having from 3 to 6 atoms, an amidino group or R.sub.1, R.sub.2 and/or R.sub.3 and R.sub.4 together represent a carbocyclic or heterocyclic group comprising from 3 to 6 atoms with the proviso that R.sub.1, R.sub.2, R.sub.3 and R.sub.4 cannot simultaneously represent hydrogen and salts thereof are fungicides especially mildewicides. Preferred compounds are those wherein the groups R represent methyl or ethyl groups.
    Type: Grant
    Filed: November 19, 1993
    Date of Patent: February 4, 1997
    Assignee: British Technology Group Limited
    Inventors: David J. Robins, Dale R. Walters
  • Optical sensor for orthogonal radiation modes
    Patent number: 5598267
    Abstract: An optical sensing device that incorporates either a surface plasmon-polariton or guided mode apparatus for converting radiation between s and p modes together with a sensor for detecting a maximum in conversion between the s and p modes.
    Type: Grant
    Filed: February 3, 1995
    Date of Patent: January 28, 1997
    Assignee: British Technology Group Limited
    Inventors: John R. Sambles, Guy P. Bryan-Brown
  • Pyridyl-propan-2-yl esters of 1-adamantane carboxylates
    Patent number: 5595995
    Abstract: Compounds having the general formula: ##STR1## wherein each of R.sup.1 and R.sup.2 independently represents hydrogen or alkyl of 1 to 4 carbon atoms;A represents --O-- or --CR.sup.4 R.sup.5, where R.sup.4 and R.sup.5 are defined as for R.sup.1 or R.sup.2 ;R.sup.3 represents an adamantyl group; andPy represents a 3- or 4-pyridyl group, as free bases or their pharmaceutically acceptable salts are useful in treating androgen-dependent, especially prostatic, cancer.
    Type: Grant
    Filed: January 18, 1995
    Date of Patent: January 21, 1997
    Assignee: British Technology Group Limited
    Inventors: Ferdinand Chan, Michael Jarman, Gerard A. Potter
  • Substituted piperazine 2-carboxylic acids useful in the treatment of central nervous system disorders
    Patent number: 5595983
    Abstract: This invention is related to compositions and methods for the treatment of central nervous system disorders comprising compounds of the general formula ##STR1## wherein X, Y, and the R groups are defined in the disclosure.
    Type: Grant
    Filed: January 10, 1995
    Date of Patent: January 21, 1997
    Assignee: British Technology Group Limited
    Inventors: Jeffrey C. Watkins, Arwel W. Jones
  • Blood flow determination
    Patent number: 5588437
    Abstract: A method of determination of blood flow including projecting a beam (B) of laser generated light (L) to move (SM) over a surface (T) beneath which blood flow in a vessel or vascular bed is to be determined, collecting (RD)light returning scattered from the beam by the surface and by blood flowing beneath, measuring a spectrum of frequencies in said collected light, determining (DA),(F) from differences in said frequencies blood flow (VS) in a vessel or vascular bed beneath said surface. A reference for the detected frequencies is provided by light returned from the surface. A map of blood flow in a false-colour flow scale can be displayed(DU).
    Type: Grant
    Filed: February 16, 1994
    Date of Patent: December 31, 1996
    Assignee: British Technology Group Limited
    Inventors: Phillip O. Byrne, Timothy J. H. Essex
  • Substituted 1,1,2-triphenylbutenes and their use in the treatment of cancer
    Patent number: 5589500
    Abstract: Compounds of the general formula (2) ##STR1## wherein n is an integer of from 3 to 10, the iodo substituent is in the 3- or 4-position and R.sup.1 and R.sup.2, which may be the same or different, represent C.sub.1-3 alkyl, especially methyl or ethyl, groups or R.sup.l represents a hydrogen atom and R.sup.2 a C.sub.1-3 alkyl group or R.sup.1 and R.sup.2 together with the nitrogen atom to which they are attached represent a saturated heterocyclic group, especially a pyrrolidino group, in the form of their free bases or pharmaceutically acceptable acid addition salts are potent anti-oestrogenic compounds useful for treatment of oestrogen-dependent cancers, especially breast cancers. Compounds where the iodine atom is radioisotopic are useful in radiotherapy or gamma ray imaging of these cancers.
    Type: Grant
    Filed: January 17, 1995
    Date of Patent: December 31, 1996
    Assignee: British Technology Group Limited
    Inventors: Karen J. Edwards, Michael Jarman, Charles A. Laughton, Stephen Neidle, Ian R. Hardcastle
  • Vaccine against Pasteurella
    Patent number: 5587166
    Abstract: A vaccine against Pasteurella comprising a proteinaceous material isolated from Pasteurella grown under iron-restricted conditions, but not from Pasteurella grown under normal conditions in vitro, which reacts in an immunoblotting test against the serum of a convalescent sheep or cow which has recovered from an infection by Pasteurella of the same serotype, together with an adjuvant.
    Type: Grant
    Filed: April 24, 1995
    Date of Patent: December 24, 1996
    Assignee: British Technology Group Limited
    Inventor: William Donachie
  • Antiviral compounds
    Patent number: 5585364
    Abstract: Compounds of formula I or a pharmaceutically acceptable salt thereof: ##STR1## in which formula R.sub.1 represents an aliphatic hydrocarbyl group; Ar represents a substituted or unsubstituted aromatic nucleus;X represents --SO.sub.2 -- or --CO-- andR.sub.2 and R.sub.3 which may be identical or different represent moieties of formula (a), (b), (c), (d), (e), (f), (g), (h) or (i): ##STR2## wherein B represents the residue of a nucleoside base of formula (A), (G), (C), (H) or (T): ##STR3## provided that when R.sub.2 and R.sub.3 both represent an unsubstituted moiety of formula (a) B represents the residue of a nucleoside base which is of formula (A), (G), (C) or (H) are of value for their antiviral activity.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 17, 1996
    Assignee: British Technology Group Limited
    Inventors: Richard T. Walker, Albert S. Jones
  • Humanized anti-CD3 specific antibodies
    Patent number: 5585097
    Abstract: Novel aglycosylated antibodies having a binding affinity for the CD3 antigen complex are of value for use in therapy, particularly in immunosuppression.
    Type: Grant
    Filed: November 8, 1993
    Date of Patent: December 17, 1996
    Assignee: British Technology Group Limited
    Inventors: Sarah L. Bolt, Michael R. Clark, Scott D. Gorman, Edward G. Routledge, Herman Waldmann
  • (gamma)-[.sup.32 p](gamma) -thioribonucleoside-5.sup.1 -triphosphates
    Patent number: 5583212
    Abstract: Nucleoside thiotriphosphates carrying .sup.32 P in the gamma-thiophosphate group, prepared by reaction between a nucleoside diphosphate and a .sup.32 P labelled thiophosphate salt, are used as thiophosphorylating agents for antibodies that bind to tumour-associated antigens. The labelled thiotriphosphates can be used to introduce a therapeutically useful .sup.32 P atom into an antibody that has been modified by the incorporation into its structure of a peptide region capable of acting as a substrate for a phosphokinase. The resulting labelled antibody can then be used for injection in anti-tumour therapy and has clinical advantages over the corresponding phosphorylated analogue.
    Type: Grant
    Filed: September 19, 1994
    Date of Patent: December 10, 1996
    Assignee: British Technology Group Limited
    Inventors: Brian M. J. Foxwell, Peter Parker, Andrew M. Creighton