Patents Assigned to Brown University Research Foundation
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Publication number: 20160000054Abstract: Genetic models of amyotrophic lateral sclerosis (ALS) are described, which can be used to identify novel treatments of ALS and therapeutic targets. Methods for making and using human-derived mutants of the Drosophila dSOD1 gene that model familial ALS are provided. Methods of identifying therapeutic ALS gene targets also are provided.Type: ApplicationFiled: June 17, 2015Publication date: January 7, 2016Applicant: Brown University Research FoundationInventor: Robert Reenan
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Publication number: 20150108423Abstract: Disclosed is a method to construct a device that includes a plurality of nanowires (NWs) each having a core and at least one shell. The method includes providing a plurality of radially encoded NWs where each shell contains one of a plurality of different shell materials; and differentiating individual ones of the NWs from one another by selectively removing or not removing shell material within areas to be electrically coupled to individual ones of a plurality of mesowires (MWs). Also disclosed is a nanowire array that contains radially encoded NWs, and a computer program product useful in forming a nanowire array.Type: ApplicationFiled: October 22, 2014Publication date: April 23, 2015Applicant: Brown University Research FoundationInventors: Andre Dehon, Charles M. Lieber, John E. Savage, Eric Rachlin
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Patent number: 8883568Abstract: Disclosed is a method to construct a device that includes a plurality of nanowires (NWs) each having a core and at least one shell. The method includes providing a plurality of radially encoded NWs where each shell contains one of a plurality of different shell materials; and differentiating individual ones of the NWs from one another by selectively removing or not removing shell material within areas to be electrically coupled to individual ones of a plurality of mesowires (MWs). Also disclosed is a nanowire array that contains radially encoded NWs, and a computer program product useful in forming a nanowire array.Type: GrantFiled: November 21, 2011Date of Patent: November 11, 2014Assignee: Brown University Research FoundationInventors: Andre Dehon, Charles M. Lieber, John E. Savage, Eric Rachlin
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Patent number: 8691766Abstract: The invention provides compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with an unstable cytoplasmic membrane, due, e.g., to an unstable dystrophin associated protein complex (DAPC); disorders associated with abnormal synapses or neuromuscular junctions, including those resulting from an abnormal MuSK activation or acetylcholine receptor (AChR) aggregation. Example of diseases include muscular dystrophies, such as Duchenne's Muscular Dystrophy, Becker's Muscular Dystrophy, neuromuscular disorders and neurological disorders.Type: GrantFiled: February 8, 2012Date of Patent: April 8, 2014Assignee: Brown University Research FoundationInventors: Justin R. Fallon, Beth A. McKechnie, Michael Rafii, Hilliary Creely, Mark A. Bowe, Alison R. Amenta, Mary Lynn Mercado, Hiroki Hagiwara
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Patent number: 8658596Abstract: The invention provides compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with an unstable cytoplasmic membrane, due, e.g., to an unstable dystrophin associated protein complex (DAPC); disorders associated with abnormal synapses or neuromuscular junctions, including those resulting from an abnormal MuSK activation or acetylcholine receptor (AChR) aggregation. Examples of diseases include muscular dystrophies, such as Duchenne's Muscular Dystrophy, Becker's Muscular Dystrophy, neuromuscular disorders and neurological disorders.Type: GrantFiled: September 14, 2010Date of Patent: February 25, 2014Assignee: Brown University Research FoundationInventors: Justin R. Fallon, Mark A. Bowe, Beth McKechnie, Michael Rafii, Alison Amenta, Mary Lynn Mercado, Hiroki Hagiwara
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Patent number: 8524829Abstract: The invention involves methods and products related to the micronization of hydrophobic drugs. A method of micronizing hydrophobic drugs using a set of solutions including an aqueous solution is provided. The invention also relates to products of micronized hydrophobic drugs and related methods of use.Type: GrantFiled: June 17, 2008Date of Patent: September 3, 2013Assignee: Brown University Research FoundationInventors: Edith Mathiowitz, Christopher Thanos, Zhi Liu
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Patent number: 8311377Abstract: Optical gratings that perform a number of functions at various wavelengths are formed by various methods that preserve spectral information within a wavelength band, the functions including: coupling radiation from one waveguide (7a3) to another (7a2), controllable gratings that operate on different wavelengths in response to external control signals.Type: GrantFiled: September 19, 2011Date of Patent: November 13, 2012Assignee: Brown University Research FoundationInventors: Daniel Levner, Martin F. Fay, Jingming Xu
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Publication number: 20120245095Abstract: The invention provides compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with an unstable cytoplasmic membrane, due, e.g., to an unstable dystrophin associated protein complex (DAPC); disorders associated with abnormal synapses or neuromuscular junctions, including those resulting from an abnormal MuSK activation or acetylcholine receptor (AChR) aggregation. Example of diseases include muscular dystrophies, such as Duchenne's Muscular Dystrophy, Becker's Muscular Dystrophy, neuromuscular disorders and neurological disorders.Type: ApplicationFiled: February 8, 2012Publication date: September 27, 2012Applicant: Brown University Research FoundationInventors: Justin R. Fallon, Beth McKechnie, Michael Rafii, Hilliary Creely, Mark A. Bowe, Alison Amenta, Mary Lynn Mercado, Hiroki Hagiwara
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Patent number: 8138154Abstract: The invention provides compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with an unstable cytoplasmic membrane, due, e.g., to an unstable dystrophin associated protein complex (DAPC); disorders associated with abnormal synapses or neuromuscular junctions, including those resulting from an abnormal MuSK activation or acetylcholine receptor (AChR) aggregation. Example of diseases include muscular dystrophies, such as Duchenne's Muscular Dystrophy, Becker's Muscular Dystrophy, neuromuscular disorders and neurological disorders.Type: GrantFiled: July 6, 2009Date of Patent: March 20, 2012Assignee: Brown University Research FoundationInventors: Justin R. Fallon, Beth McKechnie, Michael Rafii, Hilliary Creely, Mark A. Bowe, Alison Amenta, Mary Lynn Mercado, Hiroki Hagiwara
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Publication number: 20120033217Abstract: Optical gratings that perform a number of functions at various wavelengths are formed by various methods that preserve spectral information within a wavelength band, the functions including: coupling radiation from one waveguide (7a3) to another (7a2), controllable gratings that operate on different wavelengths in response to external control signals.Type: ApplicationFiled: September 19, 2011Publication date: February 9, 2012Applicant: Brown University Research FoundationInventors: Daniel LEVNER, Martin F. FAY, Jingming XU
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Patent number: 8072005Abstract: Disclosed is a method to construct a device that includes a plurality of nanowires (NWs) each having a core and at least one shell. The method includes providing a plurality of radially encoded NWs where each shell contains one of a plurality of different shell materials; and differentiating individual ones of the NWs from one another by selectively removing or not removing shell material within areas to be electrically coupled to individual ones of a plurality of mesowires (MWs). Also disclosed is a nanowire array that contains radially encoded NWs, and a computer program product useful in forming a nanowire array.Type: GrantFiled: February 2, 2006Date of Patent: December 6, 2011Assignee: Brown University Research FoundationInventors: Andre Dehon, Charles M. Lieber, John E. Savage, Eric Rachlin
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Publication number: 20110289043Abstract: The invention in some aspects relates to methods, devices and compositions for evaluating material properties, such as mechanical and rheological properties of substances, particularly biological substances, such as cells, tissues, and biological fluids. In some aspects, the invention relates to methods, devices and compositions for evaluating material properties of deformable objects, such as cells. In further aspects, the invention relates to methods, devices and compositions for diagnosing and/or characterizing disease based on material properties of biological cells.Type: ApplicationFiled: March 21, 2011Publication date: November 24, 2011Applicants: Brown University Research Foundation, Massachusetts Institute of TechnologyInventors: Subra Suresh, George E. Karniadakis, Bruce Caswell, Igor V. Pivkin, Dmitry Fedosov, David J. Quinn, Ming Dao
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Patent number: 8041163Abstract: Optical gratings that perform a number of functions at various wavelengths are formed by various methods that preserve spectral information within a wavelength band, the functions including: coupling radiation from one waveguide to another, controllable gratings that operate on different wavelengths in response to external control signals.Type: GrantFiled: February 19, 2009Date of Patent: October 18, 2011Assignee: Brown University Research FoundationInventors: Daniel Levner, Martin F. Fay, Jingming Xu
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Publication number: 20110183910Abstract: The invention provides compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with an unstable cytoplasmic membrane, due, e.g., to an unstable dystrophin associated protein complex (DAPC); disorders associated with abnormal synapses or neuromuscular junctions, including those resulting from an abnormal MuSK activation or acetylcholine receptor (AChR) aggregation. Examples of diseases include muscular dystrophies, such as Duchenne's Muscular Dystrophy, Becker's Muscular Dystrophy, neuromuscular disorders and neurological disorders.Type: ApplicationFiled: September 14, 2010Publication date: July 28, 2011Applicant: Brown University Research FoundationInventors: Justin R. Fallon, Mark A. Bowe, Beth McKechnie, Michael Rafii, Alison Amenta, Mary Lynn Mercado, Hiroki Hagiwara
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Patent number: 7816322Abstract: The invention provides compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with an unstable cytoplasmic membrane, due, e.g., to an unstable dystrophin associated protein complex (DAPC); disorders associated with abnormal synapses or neuromuscular junctions, including those resulting from an abnormal MuSK activation or acetylcholine receptor (AChR) aggregation. Examples of diseases include muscular dystrophies, such as Duchenne's Muscular Dystrophy, Becker's Muscular Dystrophy, neuromuscular disorders and neurological disorders.Type: GrantFiled: February 22, 2008Date of Patent: October 19, 2010Assignee: Brown University Research FoundationInventors: Justin R. Fallon, Mark A. Bowe, Beth McKechnie, Michael Rafii, Alison Amenta, Mary Lynn Mercado, Hiroki Hagiwara
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Patent number: 7693370Abstract: An optical component including at least one optical supergrating is provided. The optical supergrating includes a quantized refractive index profile adapted to exhibit a finite plurality of refractive indexes; which in turn are adapted to generate a reflectance spectrum in at least one spectral band corresponding to a Fourier transformed analog refractive index profile.Type: GrantFiled: December 20, 2007Date of Patent: April 6, 2010Assignee: Brown University Research FoundationInventors: Daniel Levner, Martin F. Fay
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Publication number: 20090180736Abstract: Optical gratings that perform a number of functions at various wavelengths are formed by various methods that preserve spectral information within a wavelength band, the functions including: coupling radiation from one wavelength to another, controllable gratings that operate on different wavelengths in response to external control signals.Type: ApplicationFiled: February 19, 2009Publication date: July 16, 2009Applicant: Brown University Research FoundationInventors: Daniel Levner, Martin F. Fay, Jingming Xu
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Patent number: 7496257Abstract: Optical gratings that perform a number of functions at various wavelengths are formed by various methods that preserve spectral information within a wavelength band, the functions including: coupling radiation from one waveguide to another, controllable gratings that operate on different wavelengths in response to external control signals.Type: GrantFiled: January 9, 2008Date of Patent: February 24, 2009Assignee: Brown University Research FoundationInventors: Daniel Levner, Martin F. Fay, Jingming Xu
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Patent number: 7471859Abstract: An optical waveguide has a surface. An array of separately actuated bodies is disposed proximal to the exposed surface, and an actuator separately actuates at least some of the bodies to change a spectral characteristic of a wave propagating through the waveguide. Preferably, the bodies are metal striplines, an electro-optical material is disposed between the striplines and the exposed surface, and the actuator is a CMOS chip that imposes a voltage to some or all of the lines. The voltage changes the refractive index at the interface with the surface, changing an index of refraction profile of the waveguide and effectively imposing a grating. Alternatively, the bodies are micro-beams and the actuator, also controlled by a CMOS chip, separately moves each micro-beam into and out of proximity to the surface. The grating is programmable via the CMOS chip.Type: GrantFiled: August 15, 2007Date of Patent: December 30, 2008Assignee: Brown University Research FoundationInventors: Daniel Levner, Martin F. Fay, Jonathan C. Bloch, Jeffrey Weiss
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Publication number: 20080274966Abstract: The invention provides compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with an unstable cytoplasmic membrane, due, e.g., to an unstable dystrophin associated protein complex (DAPC); disorders associated with abnormal synapses or neuromuscular junctions, including those resulting from an abnormal MuSK activation or acetylcholine receptor (AChR) aggregation. Examples of diseases include muscular dystrophies, such as Duchenne's Muscular Dystrophy, Becker's Muscular Dystrophy, neuromuscular disorders and neurological disorders.Type: ApplicationFiled: February 22, 2008Publication date: November 6, 2008Applicant: Brown University Research FoundationInventors: Justin R. Fallon, Beth McKechnie, Michael Rafii, Hilliary Creely, Mark A. Bowe, Raymond Ferri