Abstract: A nozzle assembly for forming hollow fibers, particularly a "Z-fiber" having longitudinally oriented trabeculae with the fiber wall, is disclosed. The nozzle assembly contains a replaceable nozzle cap, a replaceable seal-guide, and a retractable central bore used to supply core material for the hollow fibers. The Z-fibers are particularly useful in enabling cells, solutes, or the like, to enter the fiber wall and move longitudinally into the center of the fiber wall.

Abstract: Metallic salts of organic charge-transfer agents, such as TCNQ, TNAP, TCNE and DDQ and their derivatives, can be processed by an electron beam for a variety of useful electronic and optical applications. The metallic charge transfer salts can be used to deposit high resolution conductive lines directly without developing solutions or subsequent metallization steps. The compounds can also be employed in the conventional manner as resists for doping (i.e., ion diffusion or implantation) and to diffuse metals into substrates. In particular, elecronic devices, optical devices and image-storage devices are disclosed which can be formed by simple electron beam processed of metal charge-transfer salt films deposited on substrates.

Abstract: Methods and devices for assaying the sensitivity of of biopsied cells to therapeutic agents are disclosed. Cells are cultured in artificial organs and then contacted with a fluorogenic substrate such that living cells accumulate a characteristic amount of fluorescence. The agent is then introduced into the organ and changes in the fluorescence released by the cells serve as an indicator of the sensitivity of the cells to the agent.