Abstract: An in vitro release testing method and system for testing the ability of formulations to deliver agents across a barrier membrane is disclosed. The method may comprise steps of providing a dosage of a semi-solid formulation containing the bioactive agent, a receptor solution, and a barrier membrane to separate the semi-solid formulation and the receptor solution. The receptor solution may be a biphasic solution or an immiscible solution. The semi-solid formulation may be contacted with one side of the barrier membrane and the receptor solution with the other side of the barrier membrane for a time sufficient to produce penetration of the barrier membrane by the semi-solid formulation. The receptor solution may be sampled and assayed to determine the concentration of the bioactive agent in the receptor solution.
Type:
Grant
Filed:
April 10, 2017
Date of Patent:
February 18, 2020
Assignee:
BUFFERAD Illinois Inc.
Inventors:
Wen Yang, Kenna Krone, Jerry Z. Zhang, Xiaoyan Xu
Abstract: A topical composition and methods of making the composition is disclosed. The composition may comprise an ointment base, C11-C40 alcohols or acids, and a polymer. The ointment base may be in an amount of at least about 50% of the topical composition by weight. The polymer may be substantially soluble in the ointment base.
Type:
Grant
Filed:
October 27, 2017
Date of Patent:
June 25, 2019
Assignee:
BUFFERAD Illinois Inc.
Inventors:
Xiaoyan Xu, Wen Yang, Nguyet Le, Jerry Z. Zhang