Patents Assigned to Burroughs Wellcome Company
  • Patent number: 5644036
    Abstract: A purified preparation of an anti-CDW52 antibody which exhibits on size exclusion chromatography: a single peak under non-reducing conditions and two major peaks under reducing conditions.The preparation preferably also exhibits on conventional SDS PAGE: one main band using a non-reduced sample and two main bands using a reduced sample.Additionally the preparation exhibits on reversed phase HPLC: a single sharp peak under non-reducing conditions and two major peaks under reducing conditions. Also a process of purifying an anti-CDW52 antibody, formulations containing such a purified preparation and uses thereof.
    Type: Grant
    Filed: October 7, 1994
    Date of Patent: July 1, 1997
    Assignee: Burroughs Wellcome Company
    Inventors: Paul Ian Nicholas Ramage, Geoffrey Allen
  • Patent number: 5597708
    Abstract: The present invention relates to the P.195 gene of Plasmodium falciparum and, more specifically, to the cloning of that gene. The invention further relates to a method of producing the P.195 protein using the cloned gene. The invention also relates to a vaccine comprising the P.195 protein and to the use of same in the prophylaxis of malaria.
    Type: Grant
    Filed: December 2, 1993
    Date of Patent: January 28, 1997
    Assignee: Burroughs Wellcome Company
    Inventors: Anthony A. Holder, Michael J. Lockyer, Jasbir S. Sandhu, Valentina Riveros-Moreno, Karel G. Odink
  • Patent number: 5300282
    Abstract: Potentiating agents which enhance the efficacy of antineoplastic agents are disclosed. The potentiating agents disclosed are dibenz[b,e]oxepins such as doxepin.
    Type: Grant
    Filed: June 18, 1990
    Date of Patent: April 5, 1994
    Assignee: Burroughs-Wellcome Company
    Inventor: Ann C. King
  • Patent number: 5237052
    Abstract: The present invention provides novel antigenic preparations comprising proteinaceous material associated with adenylate cyclase activity in cultures of B. pertussis, the said preparations being useful as components of acellular whooping cough vaccines. The invention further provides methods for the isolation of such antigenic preparations.
    Type: Grant
    Filed: December 9, 1991
    Date of Patent: August 17, 1993
    Assignee: Burroughs Wellcome Company
    Inventor: Pavel Novotny
  • Patent number: 5208238
    Abstract: Potentiating agents which enhance the efficacy of antineoplastic agents are disclosed. The potentiating agents disclosed are 2-(aminoethylamino) pyridines such as (E)-3-(6-(N-(2-Dimethylaminoethyl)-4-methoxybenzylamino)-2-pyridyl)acrylic acid.
    Type: Grant
    Filed: June 10, 1992
    Date of Patent: May 4, 1993
    Assignee: Burroughs Wellcome Company
    Inventor: Ann C. King
  • Patent number: 5190949
    Abstract: Potentiating agents which enhance the efficacy of antineoplastic agents are disclosed. The potentiating agents disclosed are acrivastine esters and the pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: June 10, 1992
    Date of Patent: March 2, 1993
    Assignee: Burroughs Wellcome Company
    Inventor: Ann C. King
  • Patent number: 5124330
    Abstract: Potentiating agents which enhance the efficacy of antineoplastic agents are disclosed. The potentiating agents disclosed are piperazinyl benzyl compounds such as 1-[.alpha.-(4-chlorophenyl)-3-methoxybenzyl]-4-allylpiperazine dihydrochloride.
    Type: Grant
    Filed: June 18, 1990
    Date of Patent: June 23, 1992
    Assignee: Burroughs Wellcome Company
    Inventor: Ann C. King
  • Patent number: 5124338
    Abstract: Potentiating agents which enhance the efficacy of antineoplastic agents are disclosed. The potentiating agents disclosed are acrivastine esters and the pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: June 18, 1990
    Date of Patent: June 23, 1992
    Assignee: Burroughs Wellcome Company
    Inventor: Ann C. King
  • Patent number: 5124339
    Abstract: Potentiating agents which enhance the efficacy of antineoplastic agents are disclosed. The potentiating agents disclosed are 2-(aminoethylamino) pyridines such as (E)-3-(6-(N-(2-Dimethylaminoethyl)-4-methoxybenzylamino)-2-pyridyl)acrylic acid.
    Type: Grant
    Filed: June 18, 1990
    Date of Patent: June 23, 1992
    Assignee: Burroughs Wellcome Company
    Inventor: Ann C. King
  • Patent number: 5114951
    Abstract: Potentiating agents for combatting multiple drug resistance of susceptible tumor cells in a subject in need of such treatment are disclosed. The potentiating agents disclosed are triprolidine, cis-triprolidine, and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: April 11, 1989
    Date of Patent: May 19, 1992
    Assignee: Burroughs Wellcome Company
    Inventor: Ann C. King
  • Patent number: 4780459
    Abstract: Acaricidal compositions comprising a pyrethroid of formula ##STR1## wherein Z and Z.sup.1 are the same or different and each is halo and wherein X is hydrogen or cyano, provided that when Z and Z.sup.1 are both chloro, X must be cyano together with at least one organophosphorus compound, formulations containing them and their use for the control of veterinary ectoparasites of the sub-Orders Ixodoidea and Sarcoptiformes.
    Type: Grant
    Filed: August 7, 1984
    Date of Patent: October 25, 1988
    Assignee: Burroughs Wellcome Company
    Inventor: Michael D. Matthewson