Patents Assigned to Butamax Advanced Biofuels LLC
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Publication number: 20140093931Abstract: The invention relates to processes for the production of fermentation products such as alcohols including ethanol and butanol, and the development of microorganisms capable of producing fermentation products via an engineered pathway in the microorganisms.Type: ApplicationFiled: September 27, 2013Publication date: April 3, 2014Applicant: BUTAMAX ADVANCED BIOFUELS LLCInventors: Michael Dauner, Sunny Xiang Li, Keith H. Burlew
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Publication number: 20140080189Abstract: A method for producing butanol through microbial fermentation, in which the butanol product is removed during the fermentation by extraction into a water-immiscible organic extractant in the presence of at least one electrolyte at a concentration at least sufficient to increase the butanol partition coefficient relative to that in the presence of the salt concentration of the basal fermentation medium, is provided. The electrolyte may comprise a salt which dissociates in the fermentation medium, or in the aqueous phase of a biphasic fermentation medium, to form free ions. Also provided is a method and composition for recovering butanol from a fermentation medium.Type: ApplicationFiled: November 20, 2013Publication date: March 20, 2014Applicant: BUTAMAX ADVANCED BIOFUELS LLCInventors: Michael Charles Grady, Ranjan Patnaik
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Publication number: 20140073021Abstract: The present invention relates to the production of fermentation products such as alcohols including ethanol and butanol, and processes employing in situ product removal methods.Type: ApplicationFiled: September 12, 2013Publication date: March 13, 2014Applicant: BUTAMAX ADVANCED BIOFUELS LLCInventors: STEPHANE FRANCOIS BAZZANA, ADAM BERNFELD, KEITH H. BURLEW, JAMES TIMOTHY CRONIN, MICHAEL CHARLES GRADY, BRIAN MICHAEL ROESCH, JOSEPH J. ZAHER, RAYMOND RICHARD ZOLANDZ
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Publication number: 20140051133Abstract: Provided herein are polypeptides having ketol-aid reductoisomerase activity as well as microbial host cells comprising such polypeptides. Polypeptides provided herein may be used in biosynthetic pathways, including, but not limited to, isobutanol biosynthetic pathways.Type: ApplicationFiled: May 10, 2013Publication date: February 20, 2014Applicant: BUTAMAX ADVANCED BIOFUELS, LLCInventors: Sridhar Govindarajan, Yougen Li, Der-Ing Liao, Daniel P. O'Keefe, Jeremy Stephen Minshull, Steven Cary Rothman, Alexander Vincent Tobias
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Publication number: 20140024094Abstract: Yeast cells with reduced activity of certain enzymes involved in branched chain amino acid biosynthesis in yeast mitochondria are described. Target enzymes include threonine deaminase, isopropylmalate synthase, and optionally branched chain amino acid transaminase.Type: ApplicationFiled: May 8, 2013Publication date: January 23, 2014Applicant: Butamax Advanced Biofuels LLCInventor: Larry Cameron ANTHONY
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Publication number: 20140018581Abstract: A fermentation liquid feed including water and a product alcohol and optionally CO2 is at least partially vaporized such that a vapor stream is produced. The vapor stream is contacted with an absorption liquid under suitable conditions wherein an amount of the product alcohol is absorbed. The portion of the vapor stream that is absorbed can include an amount of each of the water, the product alcohol and optionally the CO2. The temperature at the onset of the absorption of the vapor stream into the absorption liquid can be greater than the temperature at the onset of condensation of the vapor stream in the absence of the absorption liquid. The product alcohol can be separated from the absorption liquid whereby the absorption liquid is regenerated. The absorption liquid can include a water soluble organic molecule such as an amine.Type: ApplicationFiled: September 23, 2013Publication date: January 16, 2014Applicant: BUTAMAX ADVANCED BIOFUELS LLCInventors: Michael Charles Grady, William D. Parten, Robert W. Sylvester, Joseph J. Zaher
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Patent number: 8628643Abstract: A fermentation liquid feed including water and a product alcohol and optionally CO2 is at least partially vaporized such that a vapor stream is produced. The vapor stream is contacted with an absorption liquid under suitable conditions wherein an amount of the product alcohol is absorbed. The portion of the vapor stream that is absorbed can include an amount of each of the water, the product alcohol and optionally the CO2. The temperature at the onset of the absorption of the vapor stream into the absorption liquid can be greater than the temperature at the onset of condensation of the vapor stream in the absence of the absorption liquid. The product alcohol can be separated from the absorption liquid whereby the absorption liquid is regenerated. The absorption liquid can include a water soluble organic molecule such as an amine.Type: GrantFiled: August 10, 2011Date of Patent: January 14, 2014Assignee: Butamax Advanced Biofuels LLCInventors: Michael Charles Grady, William D. Parten, Robert W. Sylvester, Joseph J. Zaher
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Patent number: 8617861Abstract: A method for producing butanol through microbial fermentation, in which the butanol product is removed during the fermentation by extraction into a water-immiscible organic extractant in the presence of at least one electrolyte at a concentration at least sufficient to increase the butanol partition coefficient relative to that in the presence of the salt concentration of the basal fermentation medium, is provided. The electrolyte may comprise a salt which dissociates in the fermentation medium, or in the aqueous phase of a biphasic fermentation medium, to form free ions. Also provided is a method and composition for recovering butanol from a fermentation medium.Type: GrantFiled: November 23, 2010Date of Patent: December 31, 2013Assignee: Butamax Advanced Biofuels LLCInventors: Michael Charles Grady, Ranjan Patnaik
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Publication number: 20130316414Abstract: A high flux of metabolites from pyruvate to 2,3-butanediol in Lactobacillus plantarum was achieved through genetic engineering. Substantial elimination of lactate dehydrogenase activity in the presence of heterologously expressed butanediol dehydrogenase activity led to 2,3 butanediol production that was at least 49% of the total of major pyruvate-derived products.Type: ApplicationFiled: April 29, 2013Publication date: November 28, 2013Applicant: Butamax Advanced Biofuels LLCInventor: Butamax Advanced Biofuels LLC
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Publication number: 20130309738Abstract: The present invention relates to processes for recovering butanol produced in a fermentative process using, for example, an ethanol production plant which has been reversibly-retrofitted for butanol production, that is, the ethanol production plant may be converted for butanol production, but can also revert to an ethanol production. The present invention also relates to processes for recovering butanol produced in a fermentative process in a butanol production plant that may be converted to ethanol production plant.Type: ApplicationFiled: May 3, 2013Publication date: November 21, 2013Applicant: BUTAMAX ADVANCED BIOFUELS LLCInventor: BUTAMAX ADVANCED BIOFUELS LLC
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Patent number: 8574406Abstract: A fermentation liquid feed including water and a product alcohol and optionally CO2 is at least partially vaporized such that a vapor stream is produced. The vapor stream is contacted with an absorption liquid under suitable conditions wherein an amount of the product alcohol is absorbed. The portion of the vapor stream that is absorbed can include an amount of each of the water, the product alcohol and optionally the CO2. The temperature at the onset of the absorption of the vapor stream into the absorption liquid can be greater than the temperature at the onset of condensation of the vapor stream in the absence of the absorption liquid. The product alcohol can be separated from the absorption liquid whereby the absorption liquid is regenerated. The absorption liquid can include a water soluble organic molecule such as an amine.Type: GrantFiled: February 8, 2011Date of Patent: November 5, 2013Assignee: Butamax Advanced Biofuels LLCInventors: Michael Charles Grady, William D. Parten, Robert W. Sylvester, Joseph J. Zaher
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Patent number: 8569552Abstract: A process for recovering butanol from a mixture comprising a water-immiscible organic extractant, water, butanol, and optionally a non-condensable gas, is provided. The butanol is selected from 1-butanol, 2-butanol, isobutanol, and mixtures thereof. An overhead stream from a first distillation column is condensed to recover a mixed condensate. An entrainer is added to at least one appropriate process stream or vessel such that the mixed condensate comprises sufficient entrainer to provide phase separation of the organic and the aqueous phases to provide for recovery of the butanol.Type: GrantFiled: September 12, 2012Date of Patent: October 29, 2013Assignee: Butamax Advanced Biofuels LLCInventors: Michael Charles Grady, William D Parten, Bruce M Vrana, Yihui Tom Xu, Joseph J Zaher
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Patent number: 8563788Abstract: A process for recovering butanol from a mixture comprising a water-immiscible organic extractant, water, butanol, and optionally a non-condensable gas, is provided. The butanol is selected from 1-butanol, 2-butanol, isobutanol, and mixtures thereof. The extractant comprises at least one solvent selected from the group consisting of C7 to C22 fatty alcohols, C7 to C22 fatty acids, esters of C7 to C22 fatty acids, C7 to C22 fatty aldehydes, and mixtures thereof.Type: GrantFiled: September 12, 2012Date of Patent: October 22, 2013Assignee: Butamax Advanced Biofuels LLCInventors: Michael Charles Grady, William D Parten, Bruce M Vrana, Yihui Tom Xu, Joseph J Zaher
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Publication number: 20130247450Abstract: A gasoline deposit control additive composition for use in a fuel comprising from about 70 to about 95 volume percent of hydrocarbons in the gasoline boiling range and from about 5 to about 30 volume percent of at least one alcohol, comprising the imine or tertiary amine product of the reaction between (a) at least one aldehyde or ketone or mixture thereof having the formula R16CHO, R16CH2CHO, R17(C=0)R18 or R17CH2(C=0)R18, wherein R16, R17, and R18 are the same or different and are each independently a straight or branched chain hydrocarbyl or aryl group that contains from 1 to 18 carbon atoms, and (b) a primary or secondary amine functionality.Type: ApplicationFiled: May 16, 2013Publication date: September 26, 2013Applicant: BUTAMAX ADVANCED BIOFUELS LLCInventor: Leslie R. Wolf
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Publication number: 20130171706Abstract: Methods for the fermentative production of four carbon alcohols is provided. Specifically, butanol, preferably isobutanol is produced by the fermentative growth of a recombinant bacterium expressing an isobutanol biosynthetic pathway.Type: ApplicationFiled: June 29, 2012Publication date: July 4, 2013Applicant: BUTAMAX ADVANCED BIOFUELS LLCInventors: Gail K. Donaldson, Andrew C. Eliot, Dennis Flint, Lori Ann Maggio-Hall, Vasantha Nagarajan
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Patent number: 8476047Abstract: In an alcohol fermentation process, oil derived from biomass is hydrolyzed into an extractant available for in situ removal of a product alcohol such as butanol from a fermentation broth. The glycerides in the oil can be catalytically (e.g., enzymatically) hydrolyzed into free fatty acids, which form a fermentation product extractant having a partition coefficient for a product alcohol greater than a partition coefficient of the oil of the biomass for the product alcohol. Oil derived from a feedstock of an alcohol fermentation process can be hydrolyzed by contacting the feedstock including the oil with one or more enzymes whereby at least a portion of the oil is hydrolyzed into free fatty acids forming a fermentation product extractant, or the oil can be separated from the feedstock prior to the feedstock being fed to a fermentation vessel, and the separated oil can be contacted with the enzymes to form the fermentation product extractant.Type: GrantFiled: December 3, 2012Date of Patent: July 2, 2013Assignee: Butamax Advanced Biofuels LLCInventors: Keith H. Burlew, Robert Dicosimo, Michael Charles Grady
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Patent number: 8465560Abstract: A gasoline deposit control additive composition for use in a fuel comprising from about 70 to about 95 volume percent of hydrocarbons in the gasoline boiling range and from about 5 to about 30 volume percent of at least one alcohol, comprising the imine or tertiary amine product of the reaction between (a) at least one aldehyde or ketone or mixture thereof having the formula R16 CHO, R16 CH2 CHO, R17 (C=0) R18 or R17 CH2 (C=0) R18, wherein R16, R17, and R18 are the same or different and are each independently a straight or branched chain hydrocarbyl or aryl group that contains from 1 to 18 carbon atoms, and (b) a primary or secondary amine functionality.Type: GrantFiled: February 1, 2010Date of Patent: June 18, 2013Assignee: Butamax Advanced Biofuels LLCInventor: Leslie R. Wolf
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Patent number: 8460439Abstract: The present invention relates to a two stage process to control the butanol concentration from fermentation broth.Type: GrantFiled: December 12, 2008Date of Patent: June 11, 2013Assignee: Butamax Advanced Biofuels LLCInventor: William D. Parten
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Patent number: 8455225Abstract: Increasing tolerance to butanol in yeast has been accomplished by increasing activity of the high osmolarity/glycerol response pathway. Yeast with increased expression of PBS2p, a mitogen activated protein kinase kinase of the MAPK module of the high osmolarity/glycerol response pathway may be used for improved butanol production.Type: GrantFiled: December 21, 2009Date of Patent: June 4, 2013Assignee: Butamax Advanced Biofuels LLCInventors: Michael G. Bramucci, Robert A. Larossa, Dana R. Smulski
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Publication number: 20110162953Abstract: A process for recovering butanol from a mixture comprising a water-immiscible organic extractant, water, butanol, and optionally a non-condensable gas, is provided. The butanol is selected from 1-butanol, isobutanol, and mixtures thereof. An overhead stream from a first distillation column is decanted into two liquid phases. The wet butanol phase is returned to the first distillation column as reflux. A bottom stream from the first distillation column is refined in a second distillation column to obtain a second overhead stream comprising butanol and a second bottoms stream comprising the extractant. The extractant comprises at least one solvent selected from the group consisting of C7 to C22 fatty alcohols, C7 to C22 fatty acids, esters of C7 to C22 fatty acids, C7 to C22 fatty aldehydes, and mixtures thereof.Type: ApplicationFiled: July 13, 2010Publication date: July 7, 2011Applicant: Butamax Advanced Biofuels LLCInventors: Yihui Tom Xu, William D. Parten