Patents Assigned to California Institute Technology
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Publication number: 20240182340Abstract: A dual-pathway system for CO2 capture in both acidified and basified streams is provided. The system may be embodied in an off-shore stand-alone facility to allow for the operation of oceanic CO2 capture to be more efficient and cost effective. Systems maintain high environmental standards by containing all intermediate acidic and alkaline solutions in a closed system so that the effluent discharged back into the ocean is at the similar pH and salinity as the feed oceanwater, with only CO2 removed. Acid and base produced by an electrodialyzer unit is used to achieve oceanwater decarbonization via gaseous CO2 removal and solid CaCO3 precipitates removal. The system is configured to require the processing of a very small fraction of the total oceanwater intake for the acid-base generation process.Type: ApplicationFiled: December 2, 2022Publication date: June 6, 2024Applicant: California Institute of TechnologyInventors: Harry A. Atwater, Chengxiang Xiang, Ibadillah A. Digdaya
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Publication number: 20240186653Abstract: Separator membranes for ion batteries and methods of producing such separator membranes are disclosed herein. The separator membranes have vertically-aligned pores that have as small as submicron diameters at one or both membrane surfaces. The separator membranes may be fabricated via a novel and innovative bidirectional freeze-casting process that produces a temperature gradient in two directions. The separator membranes disclosed herein and fabricated by this method can be used in ion batteries, such as sodium ion batteries.Type: ApplicationFiled: September 18, 2023Publication date: June 6, 2024Applicants: TalosTech LLC, California Institute of TechnologyInventors: Hansan Liu, Chun-Wei Wu, Xiaoping Lin, Katherine T. Faber
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Patent number: 11998383Abstract: An enhanced stethoscope device and method for operating the enhanced stethoscope are provided. The enhanced stethoscope device generally operates by providing stethoscope sensors, ultrasonic sensors, and other sensors to obtain a series of measurements about a subject. The series of measurements may be correlated, such as by machine learning, to extract clinically relevant information. Also described are systems and methods for ultrasonic beamsteering by interference of an audio signal with an ultrasonic signal.Type: GrantFiled: July 13, 2020Date of Patent: June 4, 2024Assignee: California Institute of TechnologyInventors: Aditya Rajagopal, Alaina Ann Brinley Rajagopal
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Patent number: 12001115Abstract: An optical device. In some embodiments, the device comprises: an input waveguide, configured to receive light; a first electro-absorption modulator, coupled to receive light from the input waveguide, and operable to produce a first output or a second output, wherein the second output has a lower amplitude than the first output; a second electro-absorption modulator, coupled to receive light from the input waveguide, and operable to produce a third output or a fourth output, wherein the fourth output has a lower amplitude than the third output; and an output waveguide, coupled to receive light from the first electro-absorption modulator and the second electro-absorption modulator, and output a combined signal comprising an output of the first electro-absorption modulator and an output of the second electro-absorption modulator.Type: GrantFiled: April 1, 2022Date of Patent: June 4, 2024Assignees: Rockley Phonics Limited, California Institute of TechnologyInventors: Arian Hashemi Talkhooncheh, Azita Emami, Yi Zhang, Aaron Zilkie
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Patent number: 11998616Abstract: The present application discloses nanoparticles carrying therapeutic agents, including chemotherapeutic agents, and targeting ligands suitable for delivering these therapeutic agents through the blood brain barrier and methods of using these patients on those patients in need of such treatment.Type: GrantFiled: March 29, 2021Date of Patent: June 4, 2024Assignee: California Institute of TechnologyInventors: Mark E. Davis, Emily A. Wyent
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Patent number: 12000735Abstract: A substrate for sensing, a method of manufacturing the substrate, and an analyzing apparatus including the substrate are provided. The substrate for sensing includes: a support layer; a plurality of metal nanoparticle clusters arranged on the support layer; and a plurality of perforations arranged among the plurality of metal nanoparticle clusters. The plurality of metal nanoparticle clusters each comprise a plurality of metal nanoparticles stacked in a three-dimensional structure. Each of the plurality of perforations transmits incident light therethrough.Type: GrantFiled: August 19, 2021Date of Patent: June 4, 2024Assignees: SAMSUNG ELECTRONICS CO., LTD., CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: Daejong Yang, Hyunjun Cho, Youngzoon Yoon, Hyuck Choo
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Patent number: 11999954Abstract: Disclosed herein are programmable, conditionally activated small interfering RNA constructs (Cond-siRNAs) and methods of making and using the same as therapeutic agents. The Cond-siRNA comprises a sensor strand, a core strand, and a guide strand, which crossover to form a sensor duplex and a RNAi duplex attached to each other to form a single structure. Upon binding an input strand to the sensor strand, the Cond-siRNA is activated and releases RNAi targeting a desired gene.Type: GrantFiled: February 10, 2021Date of Patent: June 4, 2024Assignees: Clty of Hope, California Institute of TechnologyInventors: Si-ping Han, William A. Goddard, III, Marwa Ben Haj Salah, Lisa Scherer, John J. Rossi
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Patent number: 11999964Abstract: Disclosed herein include circuits, compositions, nucleic acids, populations, systems, and methods enabling cells to sense, control, and/or respond to their own population size. In some embodiments, an orthogonal communication channel allows specific communication between engineered cells. Also described herein, in some embodiments, is an evolutionarily robust ‘paradoxical’ regulatory circuit architecture in which orthogonal signals both stimulate and inhibit net cell growth at different signal concentrations. In some embodiments, engineered cells autonomously reach designed densities and/or activate therapeutic or safety programs at specific density thresholds. Methods of treatment are also provided in some embodiments.Type: GrantFiled: August 27, 2021Date of Patent: June 4, 2024Assignee: California Institute of TechnologyInventors: Yitong Ma, Mark W. Budde, Michaelle N. Mayalu, Michael B. Elowitz
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Publication number: 20240175002Abstract: This disclosure relates to modified tryptophan synthase and more particularly to modified beta-subunits of tryptophan synthase. The disclosure further relates to cells expressing such modified subunits and methods of producing non-canonical amino acids.Type: ApplicationFiled: December 5, 2023Publication date: May 30, 2024Applicant: California Institute of TechnologyInventors: David K. Romney, Javier Murciano Calles, Jori E. Wehrmuller
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Patent number: 11992813Abstract: A membrane for water collection may include a sheet having a top surface and a bottom surface, and a plurality of conical structures disposed on the top surface of the sheet, the conical structures comprising a hydrogel material. Each conical structure of the plurality of conical structures may have a height of 1 mm to 50 mm, wherein height is measured from the top surface of the sheet to an apex of a conical structure. Each conical structure of the plurality of conical structures may have an apex angle of 10 to 60 degrees.Type: GrantFiled: July 12, 2022Date of Patent: May 28, 2024Assignee: California Institute of TechnologyInventors: Ye Shi, Julia R. Greer, Harry A. Atwater, Ognjen Ilic
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Patent number: 11994671Abstract: A focusing device includes a substrate and a plurality of scatterers provided at both sides of the substrate. The scatterers on the both sides of the focusing device may correct geometric aberration, and thus, a field of view (FOV) of the focusing device may be widened.Type: GrantFiled: July 26, 2022Date of Patent: May 28, 2024Assignees: SAMSUNG ELECTRONICS CO., LTD., CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: Amir Arbabi, Seunghoon Han, Andrei Faraon
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Publication number: 20240168358Abstract: Systems and methods for optical nanostructures that use the interference of high order Mie resonances to locally control wavefront with high quality factor in two dimensions are described. The high-order Mie-resonant metasurfaces can be used to create band-stop filters, beam deflectors, lenses, beam splitters and holograms with high quality factor.Type: ApplicationFiled: November 21, 2023Publication date: May 23, 2024Applicant: California Institute of TechnologyInventors: Claudio U. Hail, Morgan D. Foley, Ruzan Sokhoyan, Lior Michaeli, Harry A. Atwater
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Publication number: 20240167092Abstract: FRET-based analytes detection and related methods and systems are described where a pair of FRET labeled primers and/or oligonucleotides are used that are specific for target sequences located at a distance up to four time the Forster distance of the FRET chromophores presented on the FRET labeled primers and/or oligonucleotides one with respect to the other in one or more polynucleotide analyte; in particular the pair of FRET labeled primers and/or oligonucleotides is combined with a sample and subjected to one or more polynucleotide amplification reactions before measuring FRET signals from at least one FRET chromophore.Type: ApplicationFiled: March 30, 2023Publication date: May 23, 2024Applicant: California Institute of TechnologyInventors: Emil P. Kartalov, Aditya Rajagopal, Axel Scherer, Mark D. Goldberg
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Patent number: 11987737Abstract: A metamaterial shell architected on a core particle (comprising organic or inorganic material) so as to form a novel class of structurally hierarchical particle that has degrees of freedom in design parameters stemming from effective optical response of the metamaterial shell and from the electromagnetic modes in the core to elicit optical behaviours that are not easily achievable and designable in particles having simpler or smoother geometries.Type: GrantFiled: March 1, 2021Date of Patent: May 21, 2024Assignees: California Institute of Technology, The Regents of the University of MichiganInventors: Alireza Marandi, Joon Hwan Bang, Saman Jahani, Nicholas Kotov, Douglas G. Montjoy
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Patent number: 11986269Abstract: Among the various aspects of the present disclosure is the provision of systems and methods of imaging using photoacoustic computed tomography.Type: GrantFiled: November 5, 2020Date of Patent: May 21, 2024Assignee: California Institute of TechnologyInventors: Lihong Wang, Peng Hu, Lei Li
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Publication number: 20240159688Abstract: One embodiment includes a system for moisture content detection and surface evaluation, including a set of one or more antennas, a radiometer, a reflectometer, a set of one or more cameras, a Global Navigation Satellite System receiver, a memory containing an evaluation application, and a processor including a set of one or more processors, wherein the evaluation application configures the processors to evaluate a surface underneath the system by performing the steps of obtaining a plurality of measurements using the radiometer, the reflectometer, and the set of one or more cameras, obtaining a set of one or more observables based on the plurality of measurements; at a high spatial resolution, generating a set of one or more environmental products based on at least one observable from the set of one or more observables, and displaying the set of one or more environmental products on a graphical user interface.Type: ApplicationFiled: November 14, 2023Publication date: May 16, 2024Applicant: California Institute of TechnologyInventors: Kamal Oudrhiri, Javier Bosch-Lluis, Nereida Rodriguez Alvarez, Joan F. Munoz
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Patent number: 11975824Abstract: A system and method for controlling a multi-rotor aircraft that implements the unconventional use of an odd number of rotors. The odd or auxiliary rotor is designed to be smaller in diameter than the remaining main rotors and accordingly generates a smaller unbalanced torque and pitch on the aircraft. Additional configurations implement the use of smaller thrust rotors that can be used to generate thrust as well as control yaw and thus counteract any remaining unbalanced torque from the odd auxiliary rotor.Type: GrantFiled: April 21, 2021Date of Patent: May 7, 2024Assignees: California Institute of Technology, TooFon, Inc.Inventors: Morteza Gharib, Michael V. Ol, Christopher J. Dougherty
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Publication number: 20240142528Abstract: A method for abnormality detection in an energy unit includes passively detecting an abnormality in an energy unit by detecting electromagnetic radiation generated by the abnormality, the energy unit comprising at least one of an electrical energy unit and an electrochemical energy unit. A method for detecting an abnormality in an energy unit includes (a) applying a signal to the energy unit, (b) performing a plurality of measurements, at a respective plurality of different locations within the energy unit, of a response of the energy unit to the signal, and (c) processing the plurality of measurements to identify the abnormality.Type: ApplicationFiled: December 14, 2023Publication date: May 2, 2024Applicant: California Institute of TechnologyInventors: Farshid ROUMI, Jamshid ROUMI
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Patent number: 11969246Abstract: A sensor implanted in tissues and including a sensing layer is fabricated by mixing the signal transduction enzyme with non-reactive components including buffer salts and fillers, and spin coating the enzyme onto a substrate. The signal transduction enzyme is crosslinked by introducing the coated substrate in a vacuum chamber. In the chamber, a crosslinker evaporates and is deposited onto the enzyme, therefore crosslinking the enzyme.Type: GrantFiled: May 17, 2023Date of Patent: April 30, 2024Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: Samson Chen, Axel Scherer, Dvin I. Adalian, Peter Petillo, Muhammad Musab Jilani, Xiomara L. Madero, Deepan Kishore Kumar
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Publication number: 20240134061Abstract: Systems and methods for a global positioning system using Global Navigation Satellite System (GNSS) signals and Stokes Parameters in accordance with embodiments of the invention are illustrated. One embodiment includes a GNSS. The GNSS includes at least four satellites and a receiver. Each satellite includes at least one pair of antennas, and a transmitter configured to transmit GNSS positioning signals to a receiver. The receiver includes a memory containing a positioning application, and a processor comprising a set of one or more processors, the positioning application configures the processors to determine a position of the receiver by performing the steps of collecting horizontal and vertical linear components of transmitted GNSS positioning signals, computing Stokes parameters of collected GNSS signals, obtaining tuning parameters based on computed Stokes parameters, synthesizing new polarization signal using tuning parameters, and processing new polarization signal to obtain a position of the location.Type: ApplicationFiled: October 18, 2023Publication date: April 25, 2024Applicant: California Institute of TechnologyInventors: Kamal Oudrhiri, Javier Bosch-Lluis, Nereida Rodriguez Alvarez, Joan F. Munoz