Patents Assigned to Caliper Technologies Corporation
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Patent number: 6834240Abstract: Techniques for displaying chromatographic data using a graphical user interface are provided. Chromatographic separation data that is a series of measurements for a sample at a scanning location over time can be displayed on a display device in a series of bands. Additionally, the series of bands for multiple samples can be aligned on the display device.Type: GrantFiled: May 22, 2003Date of Patent: December 21, 2004Assignee: Caliper Technologies CorporationInventor: Steven J. Gallagher
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Publication number: 20040034513Abstract: Techniques for displaying chromatographic data using a graphical user interface are provided. Chromatographic separation data that is a series of measurements for a sample at a scanning location over time can be displayed on a display device in a series of bands. Additionally, the series of bands for multiple samples can be aligned on the display device.Type: ApplicationFiled: May 22, 2003Publication date: February 19, 2004Applicant: CALIPER TECHNOLOGIES CORPORATION, a Corporation of the state of DelawareInventor: Steven J. Gallagher
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Publication number: 20030104466Abstract: Integrated systems, apparatus, software, and methods for performing biochemical analysis, including DNA sequencing, genomic screening, purification of nucleic acids and other biological components and drug screening are provided. Microfluidic devices, systems and methods for using these devices and systems for performing a wide variety of fluid operations are provided. The devices and systems of are used in performing fluid operations which require a large number of iterative, successive or parallel fluid manipulations, in a microscale, or sealed and readily automated format.Type: ApplicationFiled: December 5, 2002Publication date: June 5, 2003Applicant: Caliper Technologies CorporationInventors: Michael Knapp, John Wallace Parce, Luc J. Bousse, Anne R. Kopf-Sill
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Publication number: 20030077634Abstract: The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems.Type: ApplicationFiled: August 27, 2002Publication date: April 24, 2003Applicant: Caliper Technologies CorporationInventors: John Wallace Parce, Anne R. Kopf-Sill, Luc J. Bousse
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Publication number: 20030054425Abstract: The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems.Type: ApplicationFiled: June 4, 2002Publication date: March 20, 2003Applicant: Caliper Technologies CorporationInventors: John Wallace Parce, Anne R. Kopf-Sill, Luc J. Bousse
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Publication number: 20020123133Abstract: Multiphasic microfluidic apparatus for performing product fluid manipulation and separation in a single continuous unit are provided. Related methods, kits, and compositions are also provided.Type: ApplicationFiled: August 9, 2001Publication date: September 5, 2002Applicant: Caliper Technologies CorporationInventors: Tammy Burd Mehta, Anne R. Kopf-Sill
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Patent number: 6358387Abstract: Analytical systems and methods that use a modular interface structure for providing an interface between a sample substrate and an analytical unit, where the analytical unit typically has a particular interface arrangement for implementing various analytical and control functions. Using a number of variants for each module of the modular interface structure advantageously provides cost effective and efficient ways to perform numerous tests using a particular substrate or class of substrates with a particular analytical and control systems interface arrangement. Improved optical illumination and detection system for simultaneously analyzing reactions or conditions in multiple parallel microchannels are also provided.Type: GrantFiled: March 27, 2000Date of Patent: March 19, 2002Assignee: Caliper Technologies CorporationInventors: Anne R. Kopf-Sill, Andrea W. Chow, Peter C. Jann, Morten J. Jensen, Michael Spaid, Colin B. Kennedy, Michael J. Kennedy
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Patent number: 6316781Abstract: The present invention provides microfluidic devices and systems that utilize optical detection systems, and where one or more light altering optical elements are integrated into the body structure of the microfluidic device. The resulting devices perform at least a portion of the optical manipulations used in the optical detection method employed.Type: GrantFiled: June 16, 2000Date of Patent: November 13, 2001Assignee: Caliper Technologies CorporationInventors: Robert Nagle, Colin B. Kennedy
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Patent number: 6132685Abstract: The invention provides improved systems, devices, and methods for analyzing a large number of sample compounds contained in standard multiwell microtiter plates or other array structures. The multiwell plates travel along a conveyor system to a test station having a microfluidic device. At the test station, each plate is removed from the conveyor and the wells of the multiwell plate are sequentially aligned with an input port of the microfluidic device. After at least a portion of each sample has been input into the microfluidic channel system, the plate is returned to the conveyor system. Pre and/or post testing stations may be disposed along the conveyor system, and the use of an X-Y-Z robotic arm and novel plate support bracket allows each of the samples in the wells to be input into the microfluidic network through a probe affixed to a microfluidic chip.Type: GrantFiled: August 10, 1998Date of Patent: October 17, 2000Assignee: Caliper Technologies CorporationInventors: Joseph E. Kercso, Steven A. Sundberg, Jeffrey A. Wolk, Andrew W. Toth, Calvin Y. H. Chow, J. Wallace Parce
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Patent number: 6100541Abstract: The present invention provides microfluidic devices and systems that utilize optical detection systems, and where one or more light altering optical elements are integrated into the body structure of the microfluidic device. The resulting devices perform at least a portion of the optical manipulations used in the optical detection method employed.Type: GrantFiled: February 24, 1998Date of Patent: August 8, 2000Assignee: Caliper Technologies CorporationInventors: Robert Nagle, Colin B. Kennedy
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Patent number: 6086825Abstract: Fluid introduction is facilitated through the use of a port which extends entirely through a microfluidic substrate. Capillary forces can be used to retain the fluid within the port, and a series of samples or other fluids may be introduced through a single port by sequentially blowing the fluid out through the substrate and replacing the removed fluid with an alternate fluid, or by displacing the fluid in part with additional fluid. In another aspect, microfluidic substrates have channels which varying in cross-sectional dimension so that capillary action spreads a fluid only within a limited portion of the channel network. In yet another aspect, the introduction ports may include a multiplicity of very small channels leading from the port to a fluid channel, so as to filter out particles or other contaminants which might otherwise block the channel at the junction between the channel and the introduction port.Type: GrantFiled: March 23, 1999Date of Patent: July 11, 2000Assignee: Caliper Technologies CorporationInventors: Steven A. Sundberg, J. Wallace Parce, Calvin Y. H. Chow
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Patent number: 6080295Abstract: The present invention provides for techniques for transporting materials using electrokinetic forces through the channels of a microfluidic system. The subject materials are transported in regions of high ionic concentration, next to spacer material regions of high ionic concentration, which are separated by spacer material regions of low ionic concentration. Such arrangements allow the materials to remain localized for the transport transit time to avoid mixing of the materials. Using these techniques, an electropipettor which is compatible with the microfluidic system is created so that materials can be easily introduced into the microfluidic system. The present invention also compensates for electrophoretic bias as materials are transported through the channels of the microfluidic system by splitting a channel into portions with positive and negative surface charges and a third electrode between the two portions, or by diffusion of the electrophoresing materials after transport along a channel.Type: GrantFiled: March 20, 1998Date of Patent: June 27, 2000Assignee: Caliper Technologies CorporationInventors: J. Wallace Parce, Michael R. Knapp
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Patent number: 6046056Abstract: The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems.Type: GrantFiled: December 6, 1996Date of Patent: April 4, 2000Assignee: Caliper Technologies CorporationInventors: J. Wallace Parce, Anne R. Kopf-Sill, Luc J. Bousse
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Patent number: 5972187Abstract: The present invention provides for techniques for transporting materials using electrokinetic forces through the channels of a microfluidic system. The subject materials are transported in regions of high ionic concentration, next to spacer material regions of high ionic concentration, which are separated by spacer material regions of low ionic concentration. Such arrangements allow the materials to remain localized for the transport transit time to avoid mixing of the materials. Using these techniques, an electropipettor which is compatible with the microfluidic system is created so that materials can be easily introduced into the microfluidic system. The present invention also compensates for electrophoretic bias as materials are transported through the channels of the microfluidic system by splitting a channel into portions with positive and negative surface charges and a third electrode between the two portions, or by diffusion of the electrophoresing materials after transport along a channel.Type: GrantFiled: March 20, 1998Date of Patent: October 26, 1999Assignee: Caliper Technologies CorporationInventors: J. Wallace Parce, Michael R. Knapp
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Patent number: 5965001Abstract: In a microfluidic system using electrokinetic forces, the present invention uses electrical current or electrical parameters, other than voltage, to control the movement of fluids through the channels of the system. Time-multiplexed power supplies also provide further control over fluid movement by varying the voltage on an electrode connected to a fluid reservoir of the microfluidic system, by varying the duty cycle during which the voltage is applied to the electrode, or by a combination of both. A time-multiplexed power supply can also be connected to more than one electrode for a savings in cost.Type: GrantFiled: July 3, 1997Date of Patent: October 12, 1999Assignee: Caliper Technologies CorporationInventors: Calvin Y. H. Chow, J. Wallace Parce
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Patent number: 5959291Abstract: A method and apparatus for measuring very low light signals including integrating a signal from a photo diode, avalanche photo diode, photomultiplier tube or the like, digitally sampling the integrator output more than two times during each integration period, fitting a curve to the multiple digitized readings to calculate the integration slope for each integration period and determining the original signal from the calculated integration slope.Type: GrantFiled: June 25, 1998Date of Patent: September 28, 1999Assignee: Caliper Technologies CorporationInventor: Morten J. Jensen
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Patent number: 5942443Abstract: Microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems.Type: GrantFiled: June 28, 1996Date of Patent: August 24, 1999Assignee: Caliper Technologies CorporationInventors: John Wallace Parce, Anne R. Kopf-Sill, Luc J. Bousse
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Patent number: 5885470Abstract: Microfluidic devices are provided for the performance of chemical and biochemical analyses, syntheses and detection. The devices of the invention combine precise fluidic control systems with microfabricated polymeric substrates to provide accurate, low cost miniaturized analytical devices that have broad applications in the fields of chemistry, biochemistry, biotechnology, molecular biology and numerous other fields.Type: GrantFiled: April 14, 1997Date of Patent: March 23, 1999Assignee: Caliper Technologies CorporationInventors: John Wallace Parce, Michael R. Knapp, Calvin Y. H. Chow, Luc Bousse
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Patent number: 5880071Abstract: The present invention provides for techniques for transporting materials using electrokinetic forces through the channels of a microfluidic system. The subject materials materials are transported in regions of high ionic concentration, next to spacer material regions of high ionic concentration, which are separated by spacer material regions of low ionic concentration. Such arrangements allow the materials to remain localized for the transport transit time to avoid mixing of the materials. Using these techniques, an electropipettor which is compatible with the microfluidic system is created so that materials can be easily introduced into the microfluidic system. The present invention also compensates for electrophoretic bias as materials are transported through the channels of the microfluidic system by splitting a channel into portions with positive and negative surface charges and a third electrode between the two portions, or by diffusion of the electrophoresing materials after transport along a channel.Type: GrantFiled: December 6, 1996Date of Patent: March 9, 1999Assignee: Caliper Technologies CorporationInventors: J. Wallace Parce, Michael R. Knapp
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Patent number: 5852495Abstract: The present invention provides a microfluidic system for fast, accurate and low cost electrophoretic analysis of materials in the fields of chemistry, biochemistry, biotechnology, molecular biology and numerous other fields. Light from periodically spaced regions along a channel in the microfluidic system are received by a photodetector. The intensity of light received by the photodetector is modulated by the movement of species bands through the channel under electrophoretic forces. By Fourier analysis, the velocity of each species band is determined and the identification of the species is made by its electrophoretic mobility in the channel.Type: GrantFiled: September 30, 1997Date of Patent: December 22, 1998Assignee: Caliper Technologies CorporationInventor: J. Wallace Parce