Abstract: The present invention relates to the identification of compounds and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided compounds.
Type:
Grant
Filed:
November 20, 2009
Date of Patent:
January 1, 2019
Assignees:
NORTHWESTERN UNIVERSITY, CAMBRIA PHARMACEUTICALS, INC.
Inventors:
Donald R. Kirsch, Radhia Benmohamed, Anthony C. Arvanites, Richard I. Morimoto, Tian Chen, Richard B. Silverman
Abstract: The present invention relates to the identification of provided cyclohexane-1,3-diones (CHD compounds) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided CHD compounds.
Type:
Grant
Filed:
October 20, 2015
Date of Patent:
March 14, 2017
Assignees:
Northwestern University, Cambria Pharmaceuticals, Inc.
Inventors:
Donald R. Kirsch, Radhia Benmohamed, Anthony C. Arvanites, Richard I. Morimoto, Wei Zhang, Richard B. Silverman
Abstract: The present invention relates to the identification of provided cyclohexane-1,3-diones (CHD compounds) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided CHD compounds.
Type:
Grant
Filed:
May 12, 2014
Date of Patent:
October 20, 2015
Assignees:
Northwestern University, Cambria Pharmaceuticals, Inc.
Inventors:
Donald Kirsch, Radhia Benmohamed, Anthony C. Arvanites, Richard I. Morimoto, Wei Zhang, Richard B. Silverman
Abstract: The present invention relates to the identification of provided cyclohexane-1,3-diones (CHD compounds) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided CHD compounds.
Type:
Grant
Filed:
October 29, 2010
Date of Patent:
May 13, 2014
Assignees:
Northwestern University, Cambria Pharmaceuticals, Inc.
Inventors:
Donald R. Kirsch, Radhia Benmohamed, Anthony C. Arvanites, Richard I. Morimoto, Wei Zhang, Richard B. Silverman
Abstract: The present invention relates to the identification of provided cyclohexane-1,3-diones (CHD compounds) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided CHD compounds.
Type:
Application
Filed:
October 29, 2010
Publication date:
October 18, 2012
Applicants:
Cambria Pharmaceuticals, Inc., Northwestern University
Inventors:
Donald R. Kirsch, Radhia Benmohamed, Anthony C. Arvanties, Richard I. Morimoto, Wei Zhang, Richard B. Silverman
Abstract: The present invention relates to the identification of inventive pyrimidine-2,4,6-triones (PYT compounds) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the inventive PYT compounds.
Type:
Application
Filed:
May 5, 2010
Publication date:
February 23, 2012
Applicants:
NORTHWESTERN UNIVERSITY, CAMBRIA PHARMACEUTICALS, INC.
Inventors:
Donald R. Kirsch, Radhia Benmohamed, Anthony C. Arvanites, Richard I. Morimoto, Richard B. Silverman, Guoyao Xia
Abstract: The present invention relates to the use of butaclamol and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases.
Abstract: The present invention relates to the identification of compounds and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided compounds.
Type:
Application
Filed:
November 20, 2009
Publication date:
September 29, 2011
Applicants:
CAMBRIA PHARMACEUTICALS, INC., NORTHWESTERN UNIVERSITY
Inventors:
Donald R. Kirsch, Radhia Benmohamed, Anthony C. Arvanites, Richard I. Morimoto, Tian Chen, Richard B. Silverman