Patents Assigned to Cambridge BioScience Corporation
  • Monoclonal antibodies specific for Toxin B of Clostridium difficile
    Patent number: 5231003
    Abstract: Monoclonal antibodies specific for Toxin B of Clostridium difficile are provided. Further, methods for making and using the antibodies are given, particularly the use of the antibodies for the detection of C. difficile.
    Type: Grant
    Filed: May 11, 1990
    Date of Patent: July 27, 1993
    Assignee: Cambridge Bioscience Corporation
    Inventors: Richard T. Coughlin, Dante J. Marciani
  • Detection of antibodies to human immunodeficiency virus by agglutination of antigen coated latex
    Patent number: 4921787
    Abstract: The present invention relates to an assay for determinng the presence of antibodies in a sample to human immunodeficiency virus (HIV) comprising mixing a sample suspected of containing antibodies to HIV with HIV-specific antigen coated, hydroxylated microbeads, evaluating whether agglutination occurs, and determining therefrom the presence of the antibodies to HIV in the sample.
    Type: Grant
    Filed: May 1, 1987
    Date of Patent: May 1, 1990
    Assignee: Cambridge Bioscience Corporation
    Inventors: Charles H. Riggin, Dante J. Marciani
  • Peptides for the diagnosis of HTLV-III antibodies, their preparation and use
    Patent number: 4753873
    Abstract: Certain peptide fragments of the human T-cell leukemia (lymphotropic) virus (HTLV-III) are particularly immunoreactive to HTLV-III antibodies, and can therefore be applied to immunodiagnostic tests for the detection of antibodies to HTLV-III.
    Type: Grant
    Filed: February 3, 1986
    Date of Patent: June 28, 1988
    Assignee: Cambridge Bioscience Corporation
    Inventors: Gerald A. Beltz, Richard M. Thorn, Dante J. Marciani, Chung-Ho Hung, William A. Haseltine
  • Process for purifying recombinant proteins, and products thereof
    Patent number: 4734362
    Abstract: The present invention relates to a process for recovering recombinant protein from refractile inclusion bodies of microorganisms which comprise disrupting cells, recovering refractile bodies containing recombinant protein, solubilizing the refractile bodies with a denaturant, protecting sulfhydryl groups of recombinant proteins, converting cationic amino groups of recombinant proteins to anionic carboxylic acid by derivatization with organic cyclic acid anhydrides, and recovering recombinant protein derivatives.The present invention also relates to the production of solid supports coated with recombinant protein recovered by the process of the invention, and the use of said devices for the detection and quantification of antibodies to said recombinant proteins in body fluids.
    Type: Grant
    Filed: September 25, 1986
    Date of Patent: March 29, 1988
    Assignee: Cambridge Bioscience Corporation
    Inventors: Chung-Ho Hung, Richard Thorn, Charles Riggin, Dante Marciani
  • Bacterial screening system with enhanced shelf life
    Patent number: 4728608
    Abstract: A tetrazolium-based system for testing for the presence of organisms or cells in a specimen includes in one embodiment a mixture of a substrate and an indicator system, wherein the overall system is buffered to a pH above 8.0, and in a preferred embodiment at about a pH of 9.0 when mixed. The substrate solution and indicator solution are not mixed until shortly before use. The indicator solution is buffered at a pH of approximately 3.3, thereby enhancing the shelf life. The substrate may consist of glucose with at least one amino acid in a buffered solution formulated such that, by mixing equal parts with the indicator solution, a pH above 8, preferably 9.0 results.
    Type: Grant
    Filed: April 8, 1985
    Date of Patent: March 1, 1988
    Assignee: Cambridge BioScience Corporation
    Inventors: John W. Roberts, Karen E. DeBell
  • Multiple step reagent delivery system
    Patent number: 4689204
    Abstract: The present invention relates to devices for delivering reagents for tests, and particularly for assays applicable to biological fluids.
    Type: Grant
    Filed: March 8, 1985
    Date of Patent: August 25, 1987
    Assignee: Cambridge BioScience Corporation
    Inventors: Gerald F. Buck, John W. Roberts, Steven Sable