Abstract: The present invention relates to the identification of lipid oxidising antibodies as a key pathogenic factor in atherosclerotic disorders. These disorders may be treated by inhibiting this antibody mediated lipid oxidation and methods and means for identifying and producing inhibitory agents are provided.
Abstract: The present invention relates to the identification of lipid oxidizing abzymes as a key pathogenic factor in atherosclerotic disorders. Methods and means for the reduction of abzyme mediated lipid oxidation in the vascular system are provided as therapeutic approaches for the treatment of atherosclerotic disorders. Methods are provide for determining the efficacy of treatment.
Abstract: The present invention relates to the identification of lipid oxidising antibodies as a key pathogenic factor in atherosclerotic disorders. The presence of such antibodies is a important marker for the diagnosis and prognosis of such disorders and methods and means for the assessment of athersclerotic conditions are provided herein.