Patents Assigned to Cambridge University Technical Service, Ltd.
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Patent number: 8849578Abstract: A prediction method for predicting the effect of an amino acid modification on the rate of aggregation (solubility) of a reference polypeptide comprising: calculating the difference in hydrophobicity (?Hydr) between the reference polypeptide and a modified polypeptide, calculating the difference in ?-sheet propensity (??Gcoil-?+??G?-coil) between the reference polypeptide and modified polypeptide, calculating the difference in charge (? Charge) between the reference polypeptide and modified polypeptide, and calculating: [x* ?Hydr]+[y*(??Gcoil-?+??G?-coil)]?[z*? Charge], wherein x, y and z are scaling factors.Type: GrantFiled: April 2, 2008Date of Patent: September 30, 2014Assignee: Cambridge University Technical Services Ltd.Inventors: Christopher Dobson, Fabrizio Chiti, Jesus Zurdo
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Patent number: 8155888Abstract: A method of determining aggregation rate data predicting an aggregation rate of a polypeptide defined by an amino acid sequence, the method comprising determining a hydrophobicity value, a charge value, and at least one shape propensity value for said sequence; identifying one or more aggregation-influencing patterns within said sequence; determining a pattern value for the sequence responsive to said identifying; and determining said aggregation rate data by determining a weighted combination of said hydrophobicity value, said charge value, said at least one shape propensity value, said pattern value and at least one factor extrinsic to said amino acid sequence.Type: GrantFiled: March 8, 2010Date of Patent: April 10, 2012Assignee: Cambridge University Technical Services Ltd.Inventors: Christopher Dobson, Fabrizio Chiti, Jesus Zurdo, Kateri Hayashi DuBay, Michele Vendruscolo
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Patent number: 7947272Abstract: Inducing tolerance in a primate by use of a compound, or a combination of at least two compounds, that has certain characteristics when tested in vitro. The compound, alone or in combination, is preferably TRX1 antibody and the compound or combination is preferably used in accordance with a specified dosing regimen.Type: GrantFiled: July 13, 2006Date of Patent: May 24, 2011Assignees: Tolerx, Inc., Isis Innovation, Ltd., Cambridge University Technical Services, Ltd.Inventors: Mark Frewin, Herman Waldmann, Scott Gorman, Geoff Hale, Patricia Rao, Tadeusz Kornaga, Douglas Ringler, Stephen Cobbold, Dawn Winsor-Hines
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Patent number: 7930157Abstract: A prediction method for predicting the effect of an amino acid modification on the rate of aggregation (solubility) of a reference polypeptide comprising: calculating the difference in hydrophobicity (?Hydr) between the reference polypeptide and a modified polypeptide, calculating the difference in ?-sheet propensity (??Gcoil-?+??G?-coil) between the reference polypeptide and modified polypeptide, calculating the difference in charge (? Charge) between the reference polypeptide and modified polypeptide, and calculating: [x*?Hydr]+[y*(??Gcoil-?+??G?-coil)]?[z*?Charge], wherein x, y and z are scaling factors.Type: GrantFiled: April 4, 2008Date of Patent: April 19, 2011Assignee: Cambridge University Technical Services Ltd.Inventors: Christopher Dobson, Fabrizio Chiti, Jesus Zurdo
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Publication number: 20100261882Abstract: A method of determining aggregation rate data predicting an aggregation rate of a polypeptide defined by an amino acid sequence, the method comprising determining a hydrophobicity value, a charge value, and at least one shape propensity value for said sequence; identifying one or more aggregation-influencing patterns within said sequence; determining a pattern value for the sequence responsive to said identifying; and determining said aggregation rate data by determining a weighted combination of said hydrophobicity value, said charge value, said at least one shape propensity value, said pattern value and at least one factor extrinsic to said amino acid sequence.Type: ApplicationFiled: March 8, 2010Publication date: October 14, 2010Applicant: Cambridge University Technical Services Ltd.Inventors: Christopher Doboson, Fabrizio Chiti, Jesus Zurdo, Kateri Hayashi DuBay, Michele Vendruscolo
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Patent number: 7698070Abstract: A method of determining aggregation rate data predicting an aggregation rate of a polypeptide defined by an amino acid sequence, the method comprising determining a hydrophobicity value, a charge value, and at least one shape propensity value for said sequence; identifying one or more aggregation-influencing patterns within said sequence; determining a pattern value for the sequence responsive to said identifying; and determining said aggregation rate data by determining a weighted combination of said hydrophobicity value, said charge value, said at least one shape propensity value, said pattern value and at least one factor extrinsic to said amino acid sequence.Type: GrantFiled: May 4, 2006Date of Patent: April 13, 2010Assignee: Cambridge University Technical Services Ltd.Inventors: Christopher Dobson, Fabrizio Chiti, Jesus Zurdo, Kateri Hayashi DuBay, Michele Vendruscolo
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Publication number: 20100028599Abstract: The present invention relates to a method of producing an ultrahydrophobic surface, the method comprising providing a mixture comprising low surface energy material and a sacrificial material, forming a layer from the mixture wherein the layer contains particles of the sacrificial material, treating the layer so as to destroy the particles of sacrificial material and generate a laterally continuous matrix of solid low surface energy material containing an array of depressions.Type: ApplicationFiled: May 25, 2007Publication date: February 4, 2010Applicant: Cambridge University Technical Services Ltd.Inventors: Ulrich Steiner, Pieter Van Der Wal
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Patent number: 7541443Abstract: Inducing tolerance in a primate by use of a compound, or a combination of at least two compounds, that has certain characteristics when tested in vitro. The compound, alone or in combination, is preferably TRX1 antibody and the compound or combination is preferably used in accordance with a specified dosing regimen.Type: GrantFiled: January 29, 2003Date of Patent: June 2, 2009Assignees: Tolerrx, Inc., Isis Innovation, Ltd., Cambridge University Technical Services, Ltd.Inventors: Mark Frewin, Herman Waldmann, Scott Gorman, Geoff Hale, Patricia Rao, Tadeusz Kornaga, Douglas Ringler, Stephen Cobbold, Dawn Winsor-Hines
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Patent number: 7524998Abstract: A dendron (2) comprising a focal point (4) and a plurality of fluorinated end groups (9) is disclosed, including one having a thiol, a silane, a carboxylic acid, a phosphonate or another moiety at the focal point suitable for chemisorption to a substrate (3). A self-assembled monolayer comprising a plurality of dendrons bonded to a substrate and a device comprising the self-assembled monolayer are also disclosed.Type: GrantFiled: June 30, 2005Date of Patent: April 28, 2009Assignees: Seiko Epson Corporation, Cambridge University Technical Service, Ltd.Inventors: Hitoshi Fukushima, Satoshi Nebashi, Masaya Ishida, Wilhelm J S Huck, Andrew B Holmes, Christine K Luscombe
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Patent number: 7411082Abstract: A catalyst for synthesis reaction that can allow the cross coupling reaction at an improved yield, and yet can be collected after used for the reaction and recycled, and a synthesizing method for a compound using the same catalyst for synthesis reaction.Type: GrantFiled: September 29, 2004Date of Patent: August 12, 2008Assignees: Cambridge University Technical Services Ltd., Daihatsu Motor Co., LtdInventors: Steven V. Ley, Martin D. Smith, Chandrashekar Ramarao, Antonia F. Stepan, Hirohisa Tanaka
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Patent number: 7387873Abstract: There is provided a human myeloma cell tine for use in a method for producing a human monoclonal antibody.Type: GrantFiled: January 3, 2003Date of Patent: June 17, 2008Assignee: Cambridge University Technical Services Ltd.Inventor: Abraham Karpas
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Patent number: 7379824Abstract: A prediction method for predicting the effect of an amino acid modification on the rate of aggregation (solubility) of a reference polypeptide comprising: calculating the difference in hydrophobicity (?Hydr) between the reference polypeptide and a modified polypeptide, calculating the difference in ?-sheet propensity (??Gcoil-?+??G?-coil) between the reference polypeptide and modified polypeptide, calculating the difference in charge (? Charge) between the reference polypeptide and modified polypeptide, and calculating: [x*?Hydr]+[y*(??Gcoil-?+??G?-coil)]?[z*? Charge], wherein x, y and z are scaling factors.Type: GrantFiled: July 19, 2005Date of Patent: May 27, 2008Assignee: Cambridge University Technical Services Ltd.Inventors: Christopher Dobson, Fabrizio Chiti, Jesus Zurdo
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Patent number: 7316303Abstract: A mechanical device for use in the control of mechanical forces. The device comprising first and second terminals which, in use, are connected to components in a system for controlling mechanical forces. These terminals are moveable with respect to one another. The device further comprises means connected between the terminals to control the mechanical forces at the terminals. These mechanical forces are proportional to the relative acceleration between the terminals, wherein the proportionality term is either a fixed constant or a variable function.Type: GrantFiled: July 3, 2002Date of Patent: January 8, 2008Assignee: Cambridge University Technical Services, Ltd.Inventor: Malcolm Clive Smith
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Patent number: 7307277Abstract: A field effect transistor is provided which comprises a gate electrode, a source electrode, a drain electrode, at least one organic semiconducting layer, and a hole transport layer for transferring holes from said source and drain electrodes to said organic semiconducting layer, wherein said hole transport layer comprises a layered metal chalcogenide. Processes for depositing a thin layer of a layered metal dichalcogenide on a substrate and for producing top gate structures on a layered metal chalcogenide layer in the manufacture of field effect transistors according to the invention are also provided.Type: GrantFiled: May 7, 2004Date of Patent: December 11, 2007Assignee: Cambridge University Technical Services Ltd.Inventors: Gitti Frey, Kieran John Reynolds, Henning Sirringhaus, Richard Henry Friend
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Publication number: 20070172822Abstract: The present invention relates to the cloning and characterisation of a prokaryotic DNA repair ligase, which is shown to possess a range of activities that allow the ligation and repair of non-compatible DNA ends and double strand breaks (DSBs). The enzyme has a range of applications in the manipulation and cloning of nucleic acids.Type: ApplicationFiled: August 2, 2004Publication date: July 26, 2007Applicant: CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LTDInventors: Aidan Doherty, Marina Della, Geoffrey Weller, Stephen Jackson
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Patent number: 7238711Abstract: Isolated and purified chemokine peptides, variants, and derivatives thereof, as well as chemokine peptide analogs, are provided.Type: GrantFiled: December 1, 1999Date of Patent: July 3, 2007Assignee: Cambridge University Technical Services Ltd.Inventors: David J. Grainger, Lauren Marie Tatalick
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Publication number: 20060234132Abstract: A sensor comprising a medium and, disposed throughout the volume thereof, a holographic element whose fringes are defined by different degrees of swellability in a liquid.Type: ApplicationFiled: March 11, 2004Publication date: October 19, 2006Applicant: CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LTDInventors: Colin Alexander Davidson, Jeffrey Blyth, Blanca Gonzalez
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Patent number: 7102477Abstract: A magnetic element comprises a closed loop of ferromagnetic material having an even number of magnetic domains of opposite sense. The magnetisation within the domains is in a circumferential direction, and the domains have leading and trailing walls extending from the inside to the outside of the loop. The magnetic element has a geometry such that there are at least two stable equilibrium domain configurations in which the domain walls are confined in predetermined portions of the loop and wherein the element is switchable between the stable configurations upon the application of a external magnetic field.Type: GrantFiled: August 7, 2001Date of Patent: September 5, 2006Assignee: Cambridge University Technical Services Ltd.Inventors: James Anthony Charles Bland, Bengt Johan Rothman, Luis Lopez Diaz, Mathias Kläui
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Patent number: 7067117Abstract: Isolated and purified chemokine peptides, variants, and derivatives thereof, as well as chemokine peptide analogs, are provided.Type: GrantFiled: September 11, 1998Date of Patent: June 27, 2006Assignee: Cambridge University Technical Services, Ltd.Inventors: David J. Grainger, Lauren Marie Tatalick, Suzanne T. Kanaly
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Patent number: 7063778Abstract: An apparatus for driving small volumes of fluid. The apparatus comprises a substrate and a first array of electrically conductive electrodes formed on the substrate. A second array of electrically conductive electrodes formed on the substrate, the first and second array being interlaced and being arranged such that each of the electrodes in the second array has a width in a fluid driving direction which is greater than that of each of the electrodes in the first array and such that the first and second set electrodes are positioned so that each of the electrodes of the first set is not at a position equidistant from adjacent electrodes of the second set, wherein both of the arrays of the arrays of electrode having widths in the fluid flow direction and thickness selected such that, in use, by varying the peak value of an alternating drive voltage applied thereto the direction of flow of a fluid adjacent to the arrays of electrodes can be controlled.Type: GrantFiled: January 14, 2003Date of Patent: June 20, 2006Assignee: Cambridge University Technical Services, Ltd.Inventors: Moeketsi Mpholo, Benjamin Brown, Charles Gordon Smith