Abstract: The invention relates to a holding and handling device of a syringe, which comprises a handle (1), a holding portion (2), two parallel guiding rods (3) rigidly linking the handle and the holding portion, and a gripping member (10) slidably axially mounted between both guiding rods and turning on itself around its central axia. A fixing plate (7) having a central opening is displaceably mounted parallel to the upper surface of the supporting plate (4) and is subjected to the action of springs (8) leading to maintain this fixing plate into contact with said supporting plate, in such a manner that in service position the peripheral edge (13') of the cylindrical body (13) of the syringe is maintained by jamming between the fixing plate and the supporting plate. Finally, the gripping member presents coupling openings (11, 11') cooperating in service position with the upper end (14') of the piston (14) of the syringe.