Patents Assigned to Cancer Research Ventures Limited
  • Materials and methods relating to fusion proteins an immune response
    Patent number: 7179471
    Abstract: A nucleic acid construct is provided for delivery into living cells in vivo for inducing an immune response in a patient to an antigen; the construct directing the expression of a fusion protein, said fusion protein comprising said antigen and an adjuvant sequence derived from a plant viral coat protein. Methods for making such constructs, and methods of using such constructs for the treatment of infectious disease, cancer and B cell malignancy, are provided.
    Type: Grant
    Filed: November 20, 2001
    Date of Patent: February 20, 2007
    Assignee: Cancer Research Ventures Limited
    Inventors: Natalia Savelyeva, Freda Stevenson
  • Method of improving bioavailability of orally administered drugs, a method of screening for enhancers of such bioavailability and novel pharmaceutical compositions for oral delivery of drugs
    Patent number: 7030132
    Abstract: A method for increasing the systemic exposure of cells selected from tumor cells and normal cells to an orally administered pharmaceutically active compound, wherein a bioenhancer comprising an inhibitor of BCRP is orally administered concomitantly with said orally administered pharmaceutically active compound, and in which method the inhibitor is administered simultaneously with the pharmaceutical compound.
    Type: Grant
    Filed: November 19, 2001
    Date of Patent: April 18, 2006
    Assignee: Cancer Research Ventures Limited
    Inventors: Johannes Henricus Matthias Schellens, Alfred Hermanus Schinkel
  • Guanidine derivatives, processes for preparing them and their use as pharmaceutical compositions
    Patent number: 6444706
    Abstract: The invention concerns new guanidine derivatives of formula (I), methods of preparing them and their use in drugs containing such compounds.
    Type: Grant
    Filed: March 23, 2001
    Date of Patent: September 3, 2002
    Assignee: Cancer Research Ventures Limited
    Inventors: Eberhard Amtmann, Norbert Frank, Gerhard Sauer, Gerhard Schilling
  • Guanidine derivatives, methods of preparing them and their use as drugs
    Patent number: 6284798
    Abstract: The invention concerns new guanidine derivatives of formula (I), methods of preparing them and their use in drugs containing compounds, of formula (I), wherein wherein x is —NH—NH—CH2R1 and R1 denotes C8 to C20 alkyl.
    Type: Grant
    Filed: October 18, 1999
    Date of Patent: September 4, 2001
    Assignee: Cancer Research Ventures Limited
    Inventors: Eberhard Amtmann, Norbert Frank, Gerhard Sauer, Gerhard Schilling