Abstract: The present application discloses a cerebral perfusion state classification apparatus and method, a device, and a storage medium. The method includes: acquiring, by a transceiving module, cervical blood flow data from an ultrasound data collecting device; determining, by a processor, cerebral perfusion data corresponding to the cervical blood flow data based on the cervical blood flow data and a mapping relationship between the cervical blood flow data and the cerebral perfusion data, and classifying cerebral perfusion states of a plurality of brain regions based on blood perfusion characteristics of the plurality of brain regions in the cerebral perfusion data.

Abstract: A traction apparatus, comprising a clip portion (2) and a traction portion (1), the traction portion containing a closed traction structure (11); the closed traction structure being made from an elastic material; the clip portion comprising a main clip body (23, 25) and a clip arm (24, 26); the main clip body being capable of passing through a biopsy channel (4) of an endoscope (3), the clip arm being capable of clip the closed traction structure. Also disclosed is a traction ring used for the traction apparatus, the traction ring being a single closed traction structure or being formed by connecting several closed traction structures, the traction ring being made from an elastic material.

Abstract: The invention provides a radiotherapeutical or radiosurgical system comprising at least two high-intensity radiation sources configured to rotate around a common rotation axis and a ring-shaped imaging device. A three-source configuration is considered as the most cost-effective and will be used as an example for illustration. The configuration of these high-intensity radiation sources and use of a unique compact MLC for each of the radiation sources make it possible for the system to rapidly deliver high-conformal non-coplanar stereotactic radiation treatment in one gantry rotation without any couch rotation. Therefore the invention can deliver high precision and high-conformal non-coplanar stereotactic radiation treatment to any part of the body in an extremely short time (0.1-20 seconds), which may exhibit numerous advantages over the prior art, such as reduction of radiation damage to the circulating immune cells in blood and mitigation of patient motion-induced problems, among others.

Abstract: An endoscope end cap, including a sleeve member, protrusion elements, and a movable sleeve. The sleeve member is connected to the front end of an endoscope, the sleeve member, the protrusion elements, and the movable sleeve are connected in sequence, and the movable sleeve can move freely on the outer surface of the endoscope. When the endoscope is inserted for examination, the end cap is easy to enter and does not scratch the digestive tract since the end cap has a cylinder-like structure which is smooth and has no angularity; when the endoscope is being withdrawn, the movable sleeve moves distally and abuts against the sleeve member, so as to support the protrusion elements to enable the protrusion elements to dilate the inner wall of the intestine, improving the quality of single endoscope examination, and reducing discomfort of a patient, operation risk, and operation time.

Abstract: A method for increasing the proportion of a central memory T cell (Tcm) subset in a CAR-T cell product includes adding an artificial antigenic epitope in a CAR, and activating a CAR-T by the artificial antigenic epitope, wherein the artificial antigenic epitope does not exist in other domains or segments of the CAR. A method for preparing a CAR-T cell includes: introducing the CAR into a T cell; and culturing the CAR-introduced T cell, and performing specific activation in the culture process. The preparation method can not only increase the proportion of CAR-positive T cells in the product, but also can achieve specific in vitro amplification of the Tcm subset in the CAR-positive T cells, and significantly increases the proportion of Tcm in a final product. Clinical trials show that the CAR-T cells have significantly improved amplification capacity in vivo, and improved clinical safety and effectiveness.

Abstract: The present invention relates to a multi-target electrical stimulation circuit, an electrical stimulator, and a signal output method of the electrical stimulator. The electrical stimulation circuit includes a control module, a plurality of brain wave acquisition modules and a plurality of stimulation adjustment modules. Each electrode is correspondingly provided with one brain wave acquisition module and one stimulation adjustment module, and different electrodes are used for stimulating different targets. The brain wave acquisition modules are used for acquiring brain wave signals in the corresponding electrodes and transmitting the brain wave signals to the control module. The control module is used for acquiring brain rhythm phase signals according to the received brain wave signals and outputting stimulation signals at preset waveform phase points after phase locking of the brain rhythm phase signals.

Abstract: A specific antibody for detecting the blood brain barrier early injury of cerebral ischemic stroke is characterized by specifically identifying specifically identifying DHYETDYTTGGESC in degradation fragments of an occludin protein, but not identify ing the full-length occludin protein. Therefore, the antibody can be used for specifically detecting the blood brain barrier early injury of the cerebral ischemic stroke, and can eliminate the influence of the full-length occludin protein in serum on a detection result, so that the specificity and accuracy of detecting the blood brain barrier early injury of the cerebral ischemic stroke are significantly improved.

Abstract: A minimally invasive ab interno triple surgery for open-angle glaucoma comprises knotting and fixing a suture at the head end of an optical fiber catheter; performing miosis with carbachol, injecting the viscoelastic into the anterior chamber, making a lateral incision at the infratemporal corneal limbus, and placing the optical fiber catheter; cutting the Schlemm's canal on the nasal side of the anterior chamber, inserting an optical fiber into the incision on the Schlemm's canal, and cutting off the suture; injecting the viscoelastic to expand while retreating the microcatheter, and regularly injecting the viscoelastic; making a conjunctival flap on the eye and nose side, performing anterior chamber paracentesis, clamping out the suture using intraocular microforceps, and knotting in the sclera tunnel; and suturing the conjunctival flap using the suture, coating the eyes, and covering the eyes with gauze to finish the surgery.

Abstract: An application of a marker of a calcium-overload-mediated neuronal death in a preparation of a drug for treating multiple aging-related neurodegenerative diseases and in a disease testing method is provided. The aging-related neurodegenerative diseases include an Alzheimer's disease, a Parkinson's disease, amyotrophic lateral sclerosis, or glaucoma. The marker of the calcium-overload-mediated neuronal death and the application thereof, used in the present invention, are therapeutically effective for treating the Alzheimer's disease, the Parkinson's disease, the amyotrophic lateral sclerosis, and the glaucoma. Moreover, calcium overload and TLK2 hyperphosphorylation may be used as new molecular markers for predicting a disease occurrence progress or testing a therapeutic effect.

Abstract: A specific antibody for detecting the blood brain barrier early injury of cerebral ischemic stroke is characterized by specifically identifying KTRRKMDRYDKSNIL in degradation fragments of an occludin protein, but not identifying the full-length occludin protein. Therefore, the antibody can be used for specifically detecting the blood brain barrier early injury of the cerebral ischemic stroke, and can eliminate the influence of the full-length occludin protein in serum on a detection result, so that the specificity and accuracy of detecting the blood brain barrier early injury of the cerebral ischemic stroke are obviously improved.

Abstract: An integrated biomarker system for evaluating a risk of impaired fasting glucose (IFG) and type 2 diabetes mellitus (T2DM) for the first time is disclosed. The integrated biomarker system includes quantitative determination results of L-glutamine, L-valine, L-leucine, L-lysine, L-proline, L-phenylalanine, L-arginine, L-glutamic acid, L-isoleucine, L-methionine, L-carnitine, acetyl-L-carnitine, lysophosphatidyl choline (LPC (P-16:0)), LPC (17:0), LPC (14:0) and propionyl-L-carnitine in a sample. The integrated biomarker system for IFG and T2DM of subject serum sample contains a correlative biomarker group on a biological network path to reflect the overall metabolic characteristics information of IFG and T2DM and to avoid that characteristic information of a disease cannot be reflected integrally and completely due to single or separate analysis of a biomarker.

Abstract: The present disclosure provides a fluorescently-traceable amino acid derivative and a preparation method and use thereof, and belongs to the technical field of biomedicine. In the present disclosure, an amino acid skeleton of the amino acid derivative is modified mainly by a fluorescently-traceable functional group. 4-chloro-7-nitro-2,1,3-benzoxadiazole (NBD-Cl) has low polarity and strong fluorescence, and can be used to modify an N-terminal of the amino acid skeleton to conduct subcellular imaging. Moreover, the NBD-Cl has a relatively small volume, lacks reaction orthogonality, and causes little interference with biochemical reactions of the organism itself. The results of examples show that the fluorescently-traceable amino acid derivative has a desirable biological activity and can be fluorescently traced in vivo and in vitro.

Abstract: Disclosed is a visual imaging device based on PS-OCT for early demineralization and caries of dental hard tissues, comprising a laser light source for emitting a laser light, a coupler for receiving and dividing the laser light emitted by the laser light source into a reference laser light and a detection laser light; wherein the reference laser light backtracking to the coupler and the detection laser light backtracking to the coupler are coupled and then passed through a transmission grating and a convex lens to input as an optical signal into a linear CCD detector for converting the optical signal into an electrical signal which is then input to a computer control system and collected by a built-in capture card; and the computer is configured to perform a three-dimensional reconstruction of an image and perform two-dimensional cross-section image analysis; and the computer control system is connected to the scanning galvanometer to control a vibration of the scanning galvanometer.

Abstract: A method for evaluating adverse reaction of sesquiterpenoids in zedoary turmeric oil is performed successively according to the following steps: (1) preparing a hemoglobin (Hb) solution and a to-be-determined solution; (2) taking Hb solutions with a same volume and respectively adding the same volume of the to-be-determined solution or normal saline thereto, mixing well and standing; (3) determining absorbance with a microplate reader, and comparing the absorbance of a to-be-determined solution group with the absorbance of a normal saline group to obtain a value r; wherein if r>1.5, then the result indicates that the concentration of the to-be-determined solution has a risk of causing dyspnea; wherein, r = OD OD Hb ; in the formula, OD is an absorbance at 280 nm wavelength of the to-be-determined solution after interacting with Hb; ODHb, is an absorbance at 280 nm wavelength of a blank control of normal saline after interacting with Hb.

Abstract: Provided are a CT scanning method and system, an electronic device, and a computer-readable storage medium. The method includes: determining a first coordinate of a mark point of a part to be imaged in a dual-camera coordinate system; converting the first coordinate into a second coordinate of the mark point in a CT coordinate system according to coordinate system transformation parameters; generating first locating information according to the second coordinate to drive a scanning table to move to a first location designated by the first locating information; obtaining projection images of the part to be scanned; determining second locating information and scanning information of the part to be scanned according to the projection images; and driving the scanning table to move to a second location designated by the second locating information according to the second locating information and performing CT scanning according to the scanning information.

Abstract: The present application discloses a cerebral perfusion state classification apparatus and method, a device, and a storage medium. The method includes: acquiring, by a transceiving module, cervical blood flow data from an ultrasound data collecting device; determining, by a processor, cerebral perfusion data corresponding to the cervical blood flow data based on the cervical blood flow data and a mapping relationship between the cervical blood flow data and the cerebral perfusion data, and classifying cerebral perfusion states of a plurality of brain regions based on blood perfusion characteristics of the plurality of brain regions in the cerebral perfusion data.

Abstract: The present disclosure discloses a cerebral perfusion state classification apparatus, method and device, and a model training apparatus. In the apparatus, a transceiver module is used for receiving physiological feature data from different data collection devices; and a processor is used for extracting physiological features from the physiological feature data; inputting the physiological features into a random forest model to cause a plurality of decision-making trees in the random forest model to predict a cerebral perfusion state type corresponding to the physiological features; and classifying a cerebral perfusion state based on the cerebral perfusion state type corresponding to the physiological features.

Abstract: A probiotic composition for treating rapid eye movement sleep behavior disorder, is prepared from Bacillus licheniformis, Bifidobacterium longum, Lactobacillus acidophilus, Enterococcus faecalis, and pharmaceutically acceptable adjuvants. The probiotic composition can improve the symptoms of rapid eye movement sleep behavior disorder of a patient, improve RBD symptoms of idiopathic RBD patients and PD patients, improve the motor symptoms and reduce the daily levodopa equivalent dose in PD patients.

Abstract: The present disclosure discloses a cerebral perfusion state classification apparatus, method and device, and a model training apparatus. In the apparatus, a transceiver module is used for receiving physiological feature data from different data collection devices; and a processor is used for extracting physiological features from the physiological feature data; inputting the physiological features into a random forest model to cause a plurality of decision-making trees in the random forest model to predict a cerebral perfusion state type corresponding to the physiological features; and classifying a cerebral perfusion state based on the cerebral perfusion state type corresponding to the physiological features.

Abstract: The invention relates to a poly(n-butyl cyanoacrylate) nanoparticle with dual modifications, a drug delivery system comprising the nanoparticle, and a method for preparing the nanoparticle or the drug delivery system. The nanoparticle is modified with a first modifier and a second modifier on the surface, the first modifier is a hydrophilic polymer, and the second modifier is an amino acid and/or a lipid. The invention further relates to a use of the nanoparticle in promoting drug penetration across the blood brain barrier in a subject.