Abstract: Methods and compositions for providing long term pain relief in, for example, surgery recovery, including injecting a composition comprising a plurality of microparticles having different sizes and at least one local anesthetic loaded into the microparticles at different loading levels. Extended prolonged blockage of nerve action in sheep testing was confirmed. Some of the microparticles comprise a high loading of local anesthetic. Testing in sheep showed nerve blockage for at least six days.

Abstract: Methods and compositions for providing long term pain relief in, for example, surgery recovery, including injecting a composition comprising a plurality of microparticles having different sizes and at least one local anesthetic loaded into the microparticles at different loading levels. Extended prolonged blockage of nerve action in sheep testing was confirmed. Some of the microparticles comprise a high loading of local anesthetic. Testing in sheep showed nerve blockage for at least six days.

Abstract: A microencapsulated epoxy adhesive system is disclosed comprising in admixture epoxy resin capsules and encapsulated Ancamine TL (Pacific Anchor Chemical Co.) as the curing agent. When applied, for example to a zinc plated bolt and the bolt is tightened, the capsules break and the resin cures and provides good breakaway torques.

Abstract: A highly impermeable encapsulating coating is disclosed prepared from a hydrolyzed ethylene-vinyl ester copolymer prepared by alcoholysis of, for example, ethylene-vinyl acetate using 4 to 9 times the amount of alcohol stoichiometrically required for a predetermined degree of hydrolysis.

Abstract: Microcapsules having a capsule core material surrounded by a relatively impermeable, densified protective wall and a method of producing such microcapsules are disclosed. To produce the microcapsules, an agitated system is provided including a liquid vehicle as a major component of the system and constituting a continuous first phase of the system. A plurality of discrete capsule core material entities are dispersed in the liquid vehicle and constitute a discontinuous second phase. A film-forming, cross-linkable, polymeric base material is also present in the liquid vehicle and, upon induction of phase separation within the agitated system, forms a sheath about the capsule core material entities. The formed sheath also contains entrapped liquid vehicle; however, a major portion of the entrapped liquid vehicle is subsequently extracted from the sheath, and the resulting densified polymeric base material in the sheath is then cross-linked to form a densified protective wall around the capsule core material.