Abstract: Provided are a method for fabricating a human nasal turbinate-derived mesenchymal stem cell-based 3D bioprinted construct, and a use thereof, wherein the human nasal turbinate-derived mesenchymal stem cell-based, 3D bioprinted construct is advantageous over conventional mesenchymal stem cell-based, 3D bioprinted constructs in that the former can survive and proliferate stably in vitro and/or in vivo and shows high osteogenic differentiation ability as well, therefore is expected to make a great contribution to the practical use of cellular therapeutic agents.

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating rheumatoid arthritis, and a stem cell therapeutic agent for treating rheumatoid arthritis, comprising nasal inferior turbinate-derived mesenchymal stem cells as an active ingredient. Nasal inferior turbinate-derived mesenchymal stem cells of the present invention have the effects of reducing the production of interleukin-17A (IL-17A), tumor necrosis factor-? (TNF-?), immunoglobulin G2 (IgG2a) which is an inflammation-inducing factor, and/or the proliferative ability of lymph node T cells, increasing interleukin-10 (IL-10) and/or regulatory T-cells (Treg, CD4+CD25+foxp3+ cell) that contribute to immune tolerance in spleen cells, and inhibiting the proliferation of human T-cells.

Abstract: The present invention provides a method for producing fisetin or fisetin derivatives, which is capable of mass production. The method for producing fisetin or fisetin derivatives according to the present invention is capable of mass-producing fisetin or fisetin derivatives without a purification process such as a column chromatography process.

Abstract: A method for producing a bis(fluorosulfonyl)imide lithium salt is disclosed. The method includes the steps of: (a) reacting bis(chlorosulfonyl)imide with NH4F(HF)n (n=0-10) to prepare ammonium bis(fluorosulfonyl)imide; and (b) reacting the ammonium bis(fluorosulfonyl)imide with a lithium base, wherein in at least one of steps (a) and (b), after the reaction, a process of adding an alkoxy trialkyl silane to the reaction solution to remove a fluorine anion is performed.

Abstract: A pharmaceutical composition and a health functional food composition for preventing, treating, or improving muscular diseases have licorice extract or a fraction thereof, or a compound isolated therefrom or a pharmaceutically acceptable salt thereof, as an active ingredient. The licorice extract or a fraction thereof, the compound or salt thereof induce the myoblasts proliferation and promote the differentiation into myotubes, and since the licorice extract or a fraction thereof, the compound or salt thereof has an excellent effect on regenerating damaged muscles, various muscle diseases are effectively prevented, improved or treated using the composition.

Abstract: An anticancer composition includes cervical cancer-derived autocrine motility factor (AMF) as an effective component. The cervical cancer-derived AMF has an excellent effect of inhibiting the proliferation of liver cancer, pancreatic cancer, breast cancer, lung cancer, prostate cancer, and colon cancer, and inducing cell death. The composition can be used as an anticancer therapeutic agent.

Abstract: Provided are methods for improving the proliferation and stemness of limbal stem cells (LSCs) by adding a Wnt inhibitor to a medium for limbal explant cultures. When human limbal explants are cultured according to the methods, Wnt/?-catenin signaling is inhibited, resulting in improvement of LSC proliferation, and improvement in the stemness of LSCs, and thus the LSCs may be obtained in high yield.

Abstract: The present invention relates to a cell therapy composition for preventing or treating immune disease comprising mesenchymal stem cells and immunoregulatory T-cells as an active ingredient. By infusing mesenchymal stem cells and immunoregulatory T-cells, which are the cellular therapeutic agent of the present invention, into bone marrow transplant animals, rejection to the host is suppressed after the engraftment of the transplanted bone-marrow to thus obtain the effect of reducing graft-versus-host disease and immune disease. Moreover, the effect of such GVHD reduction is much greater than the one obtained when only mesenchymal stem cells are infused. Accordingly, the cell therapy composition of the present invention having the above-mentioned effects can be useful in the prevention or treatment of immune disease.

Abstract: Provided are a method for fabricating a human nasal turbinate-derived mesenchymal stem cell-based 3D bioprinted construct, and a use thereof, wherein the human nasal turbinate-derived mesenchymal stem cell-based, 3D bioprinted construct is advantageous over conventional mesenchymal stem cell-based, 3D bioprinted constructs in that the former can survive and proliferate stably in vitro and/or in vivo and shows high osteogenic differentiation ability as well, therefore is expected to make a great contribution to the practical use of cellular therapeutic agents.

Abstract: The present invention relates to a radiation amount estimating method, and more particularly, to a radiation amount estimating method of an MRI based composite image using a lookup table. To this end, the object of the present invention is to provide a radiation dose estimating method of an MRI based composite image using a lookup table including: generating a lookup table representing a linear attenuation coefficient of a region of interest from a CT image (S100); photographing at least two of a T1 image, a T2 image, and a PETRA image of a patient from MRI equipment (S120); generating a composite image by superimposing the photographed images (S140); representing a border line of the region of interest in the composite image to distinguish the region of interest (S160); designating the linear attenuation coefficient of the lookup table in the distinguished region of interest (S180); and estimating a radiation dose based on the composite image to which the linear attenuation coefficient is designated (S200).

Abstract: The present invention relates to a method of predicting the risk of developing ankylosing spondylitis using DNA copy number variation. It was verified that the risk of developing ankylosing spondylitis can be effectively predicted using primers for detecting DNA copy number variation, of the present invention, and the sensitivity and specificity of prediction can be improved by grafting the results of single nucleotide polymorphism (SNP) measurements, and thus more fundamental approaches for preventing and treating ankylosing spondylitis are expected.

Abstract: The present invention relates to a radiation amount estimating method, and more particularly, to a radiation amount estimating method of an MRI based composite image using a lookup table. To this end, the object of the present invention is to provide a radiation dose estimating method of an MRI based composite image using a lookup table including: generating a lookup table representing a linear attenuation coefficient of a region of interest from a CT image (S100); photographing at least two of a T1 image, a T2 image, and a PETRA image of a patient from MRI equipment (S120); generating a composite image by superimposing the photographed images (S140); representing a border line of the region of interest in the composite image to distinguish the region of interest (S160); designating the linear attenuation coefficient of the lookup table in the distinguished region of interest (S180); and estimating a radiation dose based on the composite image to which the linear attenuation coefficient is designated (S200).

Abstract: The present invention relates to a composition for treating an ocular inflammatory disease, comprising hydrophilic sulfasalazine and hyaluronic acid, and a preparation method therefor. Furthermore, the present invention relates to a method for treating an ocular inflammatory disease, which comprises administering, to an individual, a therapeutically effective amount of hydrophilic sulfasalazine and hyaluronic acid.

Abstract: Provided is a method for preventing or treating hepatitis C by administrating a composition including, as an active ingredient, a Vitidis Vinferae Radix extract or a fraction thereof and, more specifically, to a Vitidis Vinferae Radix extract which is extracted with water and alcohol or a mixed solvent thereof, or a fraction thereof, which have remarkably low hepatotoxicity and exhibit an excellent effect of selectively inhibiting genome replication of a hepatitis C virus, and thus can be useful for preventing or treating hepatitis C.

Abstract: The present invention relates to a biological tissue biopsy device including a body extending in a longitudinal direction, an outer needle installed to be connected to one side of the body and be extended in a longitudinal direction and including a first tube having a hollow portion formed therein and a second tube disposed in a direction parallel to the first tube to guide a hemostatic substance, an inner needle provided inside the first tube and extending in a longitudinal direction, and a sliding means provided in the body and installed to be connected to one end of the inner needle so as to enable the inner needle to move forward and backward. Here, the sliding means causes the inner needle to move a predetermined distance from the hollow portion of the first tube and be inserted into a target site.

Abstract: A capsule endoscope for photodynamic and sonodynamic therapy is disclosed. The capsule includes: an endoscope body; a light and ultrasonic wave irradiation portion provided on the outer surface of the endoscope body and irradiating light of different wavelengths and ultrasonic waves; and a photodynamic and sonodynamic therapy portion connected to the outer surface of the endoscope body and comprising a material for photodynamic and sonodynamic therapy, wherein the photodynamic and sonodynamic therapy portion can be activated by the light and ultrasonic waves irradiated from the light and ultrasonic wave irradiation portion.

Abstract: Effective Photodynamic therapy (PDT) against C. difficile is provided using a composition including chitosan and tetracycline.

Abstract: The present invention provides a pharmaceutical composition for preventing or treating macular degeneration, which comprises benzopyran derivatives substituted with secondary amines including imidazole or pharmaceutically acceptable salts thereof as an active ingredient. The pharmaceutical composition of the present invention may be used in the form of eye drops.

Abstract: The present invention relates to an anterior capsulotomy guide device for cataract surgery. The present invention relates to an anterior capsulotomy guide device for cataract surgery which is temporarily inserted for anterior capsulotomy during cataract surgery, wherein the anterior capsulotomy guide device comprises a ring-shaped body, and a cut portion is formed by cutting a part of the body. According to the present invention, it is possible to carry out anterior capsulotomy with precise size and shape during cataract surgery, thereby maximizing the effect of cataract surgery.

Abstract: The present invention relates to a composition comprising a probe for detecting six representative causative viruses of acute enteritis (norovirus genogroup I and genogroup II, rotavirus, hepatitis A virus, coxsackievirus, astrovirus, and adenovirus), and a DNA microarray, a kit, and a detection method comprising the composition. The present invention is effective due to high specificity and sensitivity to viruses. In addition, since the causative viruses can simply be detected at low cost compared to conventional detection methods, without expensive diagnosis devices or specialists, the present invention may be effectively used as a method for diagnosing viruses causing acute enteritis.