Patents Assigned to Cayman Chemical Company, Incorporated
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Publication number: 20200002261Abstract: The present invention provides processes for preparing a prostacyclin analogue of Formula I or a pharmaceutically acceptable salt thereof, wherein R10 is a linear or branched C1-6 alkyl. The processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods. The processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride). Many of the processes of the present invention generate intermediates with improved e.e. and chemical purity; thereby eliminating the need of additional chromatography steps. And, the processes of the present invention are scalable to generate commercial quantities of the final compound.Type: ApplicationFiled: September 11, 2019Publication date: January 2, 2020Applicant: CAYMAN CHEMICAL COMPANY INCORPORATEDInventors: Kirk William Hering, Gilles CHAMBOURNIER, Gregory William ENDRES, Victor FEDIJ, Thomas James KRELL, II, Hussien Mahmoud MAHMOUD
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Patent number: 10450257Abstract: The present invention provides processes for preparing a prostacyclin analog of Formula I or a pharmaceutically acceptable salt thereof, wherein R10 is a linear or branched C1-6 alkyl. The processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods. The processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride). Many of the processes of the present invention generate intermediates with improved e.e. and chemical purity; thereby eliminating the need of additional chromatography steps. And, the processes of the present invention are scalable to generate commercial quantities of the final compound.Type: GrantFiled: January 18, 2018Date of Patent: October 22, 2019Assignee: Cayman Chemical Company IncorporatedInventors: Kirk William Hering, Gilles Chambournier, Gregory William Endres, Victor Fedij, Thomas James Krell, II, Hussein Mahmoud Mahmoud
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Publication number: 20190048086Abstract: The present invention relates to methods for treating an autoimmune disease in a human subject mediated by the presence of a citrullinated epitope QKCitAA, QRCitAA, or RRCitAA in the subject, the method comprising administering a therapeutica1ly effective amount of an antibody or a specific binding fragment thereof that specifically binds to citrullinated epitope QKCitAA, QRCitAA, or RRCitAA. Further aspects of the invention include an antibody or a specific binding fragment thereof, that specifically binds to a human citrullinated epitope QKCitAA, QRCitAA, or RRCitAA.Type: ApplicationFiled: February 10, 2017Publication date: February 14, 2019Applicant: Cayman Chemical Company IncorporatedInventor: James Leslies MOBLEY
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Patent number: 10155716Abstract: The present invention provides amine salts of the prostacyclin analogue of Formula I and processes for generating these amine salts.Type: GrantFiled: December 22, 2017Date of Patent: December 18, 2018Assignee: Cayman Chemical Company IncorporatedInventors: Gilles Chambournier, Gregory William Endres, Kirk William Hering, Victor Fedij, Hussein Mahmoud Mahmoud
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Publication number: 20180141889Abstract: The present invention provides processes for preparing a prostacyclin analogue of Formula I or a pharmaceutically acceptable salt thereof, wherein R10 is a linear or branched C1-6 alkyl. The processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods. The processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride). Many of the processes of the present invention generate intermediates with improved e.e. and chemical purity; thereby eliminating the need of additional chromatography steps. And, the processes of the present invention are scalable to generate commercial quantities of the final compound.Type: ApplicationFiled: January 18, 2018Publication date: May 24, 2018Applicant: CAYMAN CHEMICAL COMPANY INCORPORATEDInventors: Kirk William Hering, Gilles Chambournier, Gregory William Endres, Victor Fedij, Thomas James Krell, II, Hussein Mahmoud Mahmoud
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Publication number: 20180118656Abstract: The present invention provides amine salts of the prostacyclin analogue of Formula I and processes for generating these amine salts.Type: ApplicationFiled: December 22, 2017Publication date: May 3, 2018Applicant: Cayman Chemical Company IncorporatedInventors: Gilles Chambournier, Gregory William Endres, Kirk William Hering, Victor Fedij, Hussein Mahmoud Mahmoud
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Patent number: 9908834Abstract: The present invention provides processes for preparing a prostacyclin analog of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R10 is a linear or branched C1-6 alkyl. The processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods. The processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride). Many of the processes of the present invention generate intermediates with improved e.e. and chemical purity; thereby eliminating the need of additional chromatography steps. And, the processes of the present invention are scalable to generate commercial quantities of the final compound.Type: GrantFiled: May 1, 2017Date of Patent: March 6, 2018Assignee: Cayman Chemical Company IncorporatedInventors: Kirk William Hering, Gilles Chambournier, Gregory William Endres, Victor Fedij, Thomas James Krell, II, Hussein Mahmoud Mahmoud
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Patent number: 9890104Abstract: The present invention provides amine salts of the prostacyclin analogue of Formula I and processes for generating these amine salts.Type: GrantFiled: November 7, 2014Date of Patent: February 13, 2018Assignee: Cayman Chemical Company IncorporatedInventors: Gilles Chambournier, Gregory William Endres, Kirk William Hering, Victor Fedij, Hussein Mahmoud Mahmoud
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Patent number: 9708287Abstract: Compounds that function, alone or in combination, as inhibitors of pigmentation for the improvement of mammalian skin are described herein. Specifically, the compounds of the present disclosure, namely chiral, non-racemic compounds, function as pigment formation inhibitors thereof to beautify skin and discourage the production of melanins. One or more products, consumer and otherwise, comprising the chiral, non-racemic compounds are disclosed herein. Methods of employing both the compounds of the present disclosure and the products incorporating the present compounds are also disclosed herein.Type: GrantFiled: October 1, 2015Date of Patent: July 18, 2017Assignee: Cayman Chemical Company IncorporatedInventors: Mitchell A. deLong, Kalla Lynn Kvalnes, Raymond Boissy
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Publication number: 20160289158Abstract: The present invention provides amine salts of the prostacyclin analogue of Formula I and processes for generating these amine salts.Type: ApplicationFiled: November 7, 2014Publication date: October 6, 2016Applicant: CAYMAN CHEMICAL COMPANY INCORPORATEDInventors: GILLES CHAMBOURNIER, GREGORY WILLIAM ENDRES, KIRK WILLIAM HERING, VICTOR FEDIJ, HUSSEIN MAHMOUD MAHMOUD
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Patent number: 9126973Abstract: Multiheteroaryl compounds, their preparation, pharmaceutical compositions comprising these compounds, and their pharmaceutical use in the prevention and treatment of prostaglandin D2 mediated diseases and conditions that may be modulated by the inhibition of hematopoietic prostaglandin D synthase (H-PGDS).Type: GrantFiled: September 29, 2014Date of Patent: September 8, 2015Assignee: CAYMAN CHEMICAL COMPANY, INCORPORATEDInventors: Gregory W. Endres, Pil Heui Lee, Kirk Lang Olson, James Bernard Kramer, Fred Lawrence Ciske, Stephen Douglas Barrett
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Patent number: 9120820Abstract: Assay methods may generally comprise forming homogeneous assay mixtures comprising target SAM-utilizing protein, fluorescent detection analyte, and test compound, incubating, and measuring FP or TR-FRET signal emitted in order to determine a measure of test compound-SAM -utilizing protein binding. Assay mixtures comprise a SAM-utilizing protein, and a fluorescent detection analyte that binds with the SAM-utilizing protein in the absence of test compound. Assay mixtures may further comprise a test compound. Assay mixture embodiments may generate FP or TR-FRET signal properties that are a function of the inherent binding interactions of both the test compound and the detection analyte with the SAM-utilizing protein. Fluorescent detection analytes comprise a fluorophore moiety, a covalent linker moiety, and a SAM-utilizing protein ligand moiety and could be utilized in FP or TR-FRET assays to measure test compound binding.Type: GrantFiled: May 18, 2012Date of Patent: September 1, 2015Assignees: CAYMAN CHEMICAL COMPANY, INCORPORATED, THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Stephen Douglas Barrett, Daniel Austin Bochar, Levi Lynn Blazer, Fred Lawrence Ciske, Gregory William Endres, Jeffrey Keith Johnson, Gregory Scott Keyes, Ranjinder Singh Sidhu, Raymond C. Trievel, Margaret Lynn Collins
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Patent number: 8901319Abstract: A process for the synthesis and purification of F-series prostaglandin compounds and synthetic intermediates used to prepare them. The synthetic intermediates are solid and may be purified by precipitation and therefore may form the representative F-series prostaglandin compounds such as latanoprost, bimatoprost, fluprostenol, cloprostenol, and substituted analogs therefrom in highly pure forms.Type: GrantFiled: October 16, 2009Date of Patent: December 2, 2014Assignee: Cayman Chemical Company, IncorporatedInventors: Gilles Chambournier, Andriy Kornilov, Hussein M. Mahmoud, Ivan Vesely, Stephen D. Barrett
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Patent number: 8680327Abstract: The present invention generally relates to synthetic methods for preparing tetranor-prostaglandin D, J, E, A, and F metabolites.Type: GrantFiled: June 14, 2011Date of Patent: March 25, 2014Assignee: Cayman Chemical Company, IncorporatedInventors: Gregory W. Endres, Andriy M. Kornilov, Adam Uzieblo
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Patent number: 8536185Abstract: Multiheteroaryl compounds, their preparation, pharmaceutical compositions comprising these compounds, and their pharmaceutical use in the prevention and treatment of prostaglandin D2 mediated diseases and conditions that may be modulated by the inhibition of hematopoietic prostaglandin D synthase (H-PGDS).Type: GrantFiled: September 22, 2009Date of Patent: September 17, 2013Assignee: Cayman Chemical Company, IncorporatedInventors: Gregory W. Endres, Pil Heui Lee, Kirk Lang Olson, James Bernard Kramer, Fred Lawrence Ciske, Stephen Douglas Barrett
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Patent number: 8450326Abstract: Multiheteroaryl compounds, their preparation, pharmaceutical compositions comprising these compounds, and their pharmaceutical use in the prevention and treatment of prostaglandin D2 mediated diseases and conditions that may be modulated by the inhibition of hematopoietic prostaglandin D synthase (H-PGDS).Type: GrantFiled: September 22, 2009Date of Patent: May 28, 2013Assignee: Cayman Chemical Company, IncorporatedInventors: Gregory W. Endres, Pil Heui Lee, Kirk Lang Olson, James Bernard Kramer, Fred Lawrence Ciske, Stephen Douglas Barrett
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Patent number: 8440417Abstract: An exemplary embodiment may be directed to a fluorescence polarization assay that screens compounds or agents for their affinity to hematopoietic prostaglandin D synthase (H-PGDS) based on their ability to displace a fluorophore-containing detection analyte bound to an enzyme comprising the primary amino acid sequence of H-PGDS. Another exemplary embodiment utilizes an enzyme having a maltose binding protein amino-acid sequence fused with an N-terminus of the enzyme.Type: GrantFiled: May 13, 2009Date of Patent: May 14, 2013Assignee: Cayman Chemical Company, IncorporatedInventors: Nisha Palackal, Jeffrey K. Johnson, Karie L. McGowan, Kirk W. Maxey, Gregory W. Endres
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Publication number: 20130079375Abstract: Multiheteroaryl compounds, their preparation, pharmaceutical compositions comprising these compounds, and their pharmaceutical use in the prevention and treatment of prostaglandin D2 mediated diseases and conditions that may be modulated by the inhibition of hematopoietic prostaglandin D synthase (H-PGDS).Type: ApplicationFiled: November 1, 2012Publication date: March 28, 2013Applicant: CAYMAN CHEMICAL COMPANY, INCORPORATEDInventor: Cayman Chemical Company, Incorporated
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Publication number: 20120295283Abstract: Assay methods may generally comprise forming homogeneous assay mixtures comprising target SAM-utilizing protein, fluorescent detection analyte, and test compound, incubating, and measuring FP or TR-FRET signal emitted in order to determine a measure of test compound-SAM-utilizing protein binding. Assay mixtures comprise a SAM-utilizing protein, and a fluorescent detection analyte that binds with the SAM-utilizing protein in the absence of test compound. Assay mixtures may further comprise a test compound. Assay mixture embodiments may generate FP or TR-FRET signal properties that are a function of the inherent binding interactions of both the test compound and the detection analyte with the SAM-utilizing protein. Fluorescent detection analytes comprise a fluorophore moiety, a covalent linker moiety, and a SAM-utilizing protein ligand moiety and could be utilized in FP or TR-FRET assays to measure test compound binding.Type: ApplicationFiled: May 18, 2012Publication date: November 22, 2012Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, CAYMAN CHEMICAL COMPANY, INCORPORATEDInventors: Stephen Douglas Barrett, Daniel Austin Bochar, Levi Lynn Blazer, Fred Lawrence Ciske, Gregory William Endres, Jeffrey Keith Johnson, Gregory Scott Keyes, Ranjinder Singh Sidhu, Raymond C. Trievel, Margaret Lynn Collins
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Publication number: 20120041229Abstract: The present invention generally relates to synthetic methods for preparing tetranor-prostaglandin D, J, E, A, and F metabolites.Type: ApplicationFiled: June 14, 2011Publication date: February 16, 2012Applicant: Cayman Chemical Company, IncorporatedInventors: Gregory W. Endres, Andriy M. Kornilov, Adam Uzieblo