Abstract: The present invention relates to the use of Raman spectroscopy for the monitoring and assessment of viral titre.

Abstract: A sample heating/cooling device (2) comprises a plurality of members (6) operable in use to heat and/or cool one or more samples (22). Each member (6) has a sample contact surface and is biased towards a resting position under the operation of a biasing means. The members (6) are movable independently of one another against said bias under the application of a force on the sample contact surface and so are able to conform to the shape of a sample placed on the members to provide a uniform heating/cooling profile. The members (6) may be mounted in a heating/cooling element (4) and adapted to conduct thermal energy between the sample (22) and the element (4). The device (2) is particularly suitable for thawing frozen sample bags having an irregular shape. A corresponding method is also described.

Abstract: The present invention relates to the use of Raman spectroscopy for the monitoring and assessment of viral titre and/or viral component abundance.

Abstract: The use of Raman spectroscopy for the monitoring and assessment of viral titre is disclosed. A method of quantifying viral titre in a sample using Raman spectroscopy, comprises the steps of: (a) providing a sample and irradiating the sample with a light source; (b) measuring the total intensity of Raman scattered light within each one of a plurality of wavenumber ranges to obtain a wavenumber intensity data set for the sample, wherein the plurality of wavenumber ranges are pre-selected and are characteristic of the vims in the sample; (c) performing mathematical data processing steps on the wavenumber intensity data; and (d) quantifying the viral titre based upon the output of the mathematical data processing steps.

Abstract: The use of Raman spectroscopy for the monitoring and assessment of viral titre is disclosed. A method of quantifying viral titre in a sample using Raman spectroscopy, comprises the steps of: (a) providing a sample and irradiating the sample with a light source; (b) measuring the total intensity of Raman scattered light within each one of a plurality of wavenumber ranges to obtain a wavenumber intensity data set for the sample, wherein the plurality of wavenumber ranges are pre-selected and are characteristic of the vims in the sample; (c) performing mathematical data processing steps on the wavenumber intensity data; and (d) quantifying the viral titre based upon the output of the mathematical data processing steps.

Abstract: A sample heating/cooling device comprises a plurality of members operable in use to heat and/or cool one or more samples. Each member has a sample contact surface and is biased towards a resting position under the operation of a biasing means. The members are movable independently of one another against said bias under the application of a force on the sample contact surface and so are able to conform to the shape of a sample placed on the members to provide a uniform heating/cooling profile. The members may be mounted in a heating/cooling element and adapted to conduct thermal energy between the sample and the element. The device is particularly suitable for thawing frozen sample bags having an irregular shape. A corresponding method is also described.