Abstract: Compositions and methods for the treatment of anorectal disorders are provided in which certain combinations of NO donors, PDE inhibitors, superoxide (O2−) scavengers, &bgr;-adrenergic agonists, cAMP-dependent protein kinase activators, &agr;1-adrenergic antagonists, L-type Ca2+ channel blockers, estrogens, ATP-sensitive K+ channel activators and smooth muscle relaxants are used.
Type:
Grant
Filed:
June 14, 2000
Date of Patent:
May 21, 2002
Assignee:
Cellergy Pharmaceuticals, Inc.
Inventors:
Thomas P. Parks, Vivien Mak, Jung-Chung Lee, Charles Lee