Patents Assigned to Cellink Bioprinting AB
  • Patent number: 11931966
    Abstract: Systems and methods for optical assessments of bioink printability are described. The systems and methods include the use of hardware, software and optical targets to aid in the evaluation of bioink printability. The optical targets are developed and fabricated from 3D printable materials determined to be “nozzle fidelic” and/or materials that possess well characterized thermosensitivity. The optical targets make it possible to rapidly compare and evaluate bioink printability and can be easily customized and tailored for specific applications.
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: March 19, 2024
    Assignee: CELLINK BIOPRINTING AB
    Inventors: Patrick Thayer, Hany Abushall, Hector Martinez, Erik Gatenholm
  • Patent number: 11648336
    Abstract: The present invention relates to preparation of bioink composed of cellulose nanofibril hydrogel with native or synthetic Calcium containing particles. The concentration of the calcium containing particles can be between 1% and 40% w/v. Such bioink can be 3D Bioprinted with or without human or animal cells. Coaxial needle can be used where cellulose nanofibril hydrogel filled with Calcium particles can be used as shell and another hydrogel based bioink mixed with cells can be used as core or opposite. Such 3D Bioprinted constructs exhibit high porosity due to shear thinning properties of cellulose nanofibrils which provides excellent printing fidelity. They also have excellent mechanical properties and are easily handled as large constructs for patient-specific bone cavities which need to be repaired. The porosity promotes vascularization which is crucial for oxygen and nutrient supply. The porosity also makes it possible for further recruitment of cells which accelerate bone healing process.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: May 16, 2023
    Assignee: Cellink Bioprinting AB
    Inventors: Paul Gatenholm, Hector Martinez, Michela Schettino, Erik Gatenholm
  • Patent number: 11590710
    Abstract: The present disclosure relates to a 3D bioprinter (1) comprising a base unit (2). The base unit (2) has a support (3) adapted for mounting of at least one toolhead (4), a communication interface part (5) for communication of data with the at least one toolhead (4), when mounted, and a base unit processing element (7) adapted to communicate with a toolhead processing element (8) of the at least one toolhead over said communication interface part (5). The present disclosure relates further to a 3D bioprinter toolhead. The present disclosure relates further to a method for bioprinting a construct.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: February 28, 2023
    Assignee: Cellink Bioprinting AB
    Inventors: Erik Sternå, Jockum Svanberg, Erik Gatenholm, Hector Martinez
  • Patent number: 11548199
    Abstract: The present disclosure relates to a 3D printer (1) for 3D printing of a construct. The 3D printer (1) has a print bed (2). The 3D printer further comprises at least one actuating tool head (3) with an extrusion element (4), wherein the extrusion element and the print bed are movable in relation to each other. The 3D printer also comprises at least one sensor (5) arranged to sense a force applied to the print bed (2) by the extrusion element (4), or vice versa. The 3D printer additionally comprises a control element (7) arranged to detect when the sensed force exceeds a predetermined value and to record a position of the print bed or extrusion element related to the detection that the predetermined value is exceeded. The present disclosure also relates to corresponding methods and computer programs.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: January 10, 2023
    Assignee: Cellink Bioprinting AB
    Inventors: Erik Sternå, Jockum Svanberg, Erik Gatenholm, Hector Martinez
  • Patent number: 11370171
    Abstract: Clean chamber technology for 3D printers and bioprinters is described. An airtight chamber or enclosure is provided so that positive pressure can be created inside the chamber. Unfiltered air is sucked in from outside into the chamber through a high efficiency filter such as a HEPA filter, using an electrically powered fan or blower, filtering out at least about 99% of particles and contaminants. The filtered air is then pushed into a 3D printing area inside the chamber and out through vents within the frame of the chamber. The technology provides a clean environment for 3D bioprinting of human tissue models and organs and 3D cell culturing without requiring clean room facilities.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: June 28, 2022
    Assignee: Cellink Bioprinting AB
    Inventors: Erik Gatenholm, Ivan Tournier, Paul Gatenholm