Patents Assigned to Cellphire, Inc.
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Publication number: 20240139252Abstract: Provided herein are methods and compositions for treating von Willebrand disease with platelets, platelet derivatives, and/or thrombosomes.Type: ApplicationFiled: January 5, 2024Publication date: May 2, 2024Applicant: Cellphire, Inc.Inventors: Keith Andrew MOSKOWITZ, Shan XU, William Matthew DICKERSON, Amber Nicole LEE, Braden Carl ISHLER, Daniel Allen SHEIK
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Patent number: 11965178Abstract: In some embodiments provided herein is a method of preparing cargo-loaded platelets, comprising: treating platelets with a cargo and with a loading buffer comprising a salt, a base, a loading agent, and optionally ethanol, to form the cargo-loaded platelets.Type: GrantFiled: November 27, 2019Date of Patent: April 23, 2024Assignee: Cellphire, Inc.Inventors: Keith Andrew Moskowitz, Rafael Jorda, Ying Yi Zheng, Daniel Allen Sheik
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Publication number: 20240066065Abstract: In some embodiments provided herein is a method of treating a coagulopathy in a subject, the method including administering to the subject in need thereof an effective amount of a composition including platelets or platelet derivatives and an incubating agent including one or more salts, a buffer, optionally a cryoprotectant, and optionally an organic solvent.Type: ApplicationFiled: November 7, 2023Publication date: February 29, 2024Applicant: Cellphire, Inc.Inventors: Keith Andrew MOSKOWITZ, Braden Carl ISHLER, William Matthew DICKERSON, Amber Nicole LEE, Shan XU
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Patent number: 11903971Abstract: Provided herein are methods and compositions for treating von Willebrand disease with platelets, platelet derivatives, and/or thrombosomes.Type: GrantFiled: February 3, 2021Date of Patent: February 20, 2024Assignee: Cellphire, Inc.Inventors: Keith Andrew Moskowitz, Shan Xu, William Matthew Dickerson, Amber Nicole Lee, Braden Carl Ishler, Daniel Allen Sheik
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Publication number: 20230383258Abstract: Provided herein are RNA agent-loaded platelets, methods of preparing RNA agent-loaded platelets, and methods of using RNA agent-loaded platelets. In some embodiments, methods of loading RNA agents into platelets include treating platelets with a RNA agent, a cationic transfection reagent, and a loading buffer that can include a salt, a base, a loading agent, and optionally at least one organic solvent.Type: ApplicationFiled: July 28, 2023Publication date: November 30, 2023Applicant: Cellphire, Inc.Inventors: Keith Andrew MOSKOWITZ, Amber Nicole LEE, Rafael JORDA
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Patent number: 11813572Abstract: Provided herein are materials and methods for the preparation of blood products. In one aspect, provided herein is a composition including platelets or platelet derivatives and an aqueous medium, wherein the aqueous medium has a protein concentration less than 50% of the protein concentration of donor apheresis plasma.Type: GrantFiled: January 20, 2023Date of Patent: November 14, 2023Assignee: Cellphire, Inc.Inventors: Joshua Donald Montgomery, Braden Carl Ishler, Stephen Edward Amos, Keith Andrew Moskowitz, Amber Nicole Lee, Rafael Jorda, Glen Michael Fitzpatrick, Michael Alexander Mathews
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Publication number: 20230356150Abstract: Provided herein are materials and methods for the preparation of blood products. In one aspect, provided herein is a composition including platelets or platelet derivatives and an aqueous medium, wherein the aqueous medium has a protein concentration less than 50% of the protein concentration of donor apheresis plasma.Type: ApplicationFiled: June 26, 2023Publication date: November 9, 2023Applicant: Cellphire, Inc.Inventors: Joshua Donald MONTGOMERY, Braden Carl ISHLER, Stephen Edward Amos, Keith Andrew Moskowitz, Amber Nicole LEE, Rafael JORDA, Glen Michael FITZPATRICK, Michael Alexander Mathews
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Publication number: 20230346839Abstract: Provided herein is a composition of matter comprising dried blood plasma substantially free of blood cell components; and a) a resuscitative mixture comprising at least one saccharide, at least one salt, and at least one high molecular weight, non-ionic, hydrophilic polymer, b) platelets or platelet-derived material, or c) both a) and b).Type: ApplicationFiled: July 5, 2023Publication date: November 2, 2023Applicant: Cellphire, Inc.Inventors: Biplob BHATTACHARYA, Anne S. HALE, Rafael JORDA, Glen Michael FITZPARTICK
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Patent number: 11767511Abstract: Provided herein are RNA agent-loaded platelets, methods of preparing RNA agent-loaded platelets, and methods of using RNA agent-loaded platelets. In some embodiments, methods of loading RNA agents into platelets include treating platelets with a RNA agent, a cationic transfection reagent, and a loading buffer that can include a salt, a base, a loading agent, and optionally at least one organic solvent.Type: GrantFiled: November 27, 2019Date of Patent: September 26, 2023Assignee: Cellphire, Inc.Inventors: Keith Andrew Moskowitz, Amber Nicole Lee, Rafael Jorda
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Publication number: 20230285465Abstract: In some embodiments provided herein is a method of treating a coagulopathy in a subject, the method including administering to the subject in need thereof an effective amount of a composition including platelets or platelet derivatives and an incubating agent including one or more salts, a buffer, optionally a cryoprotectant, and optionally an organic solvent, wherein the subject has been treated or is being treated with an antiplatelet agent.Type: ApplicationFiled: May 16, 2023Publication date: September 14, 2023Applicant: Cellphire, Inc.Inventors: Keith Andrew MOSKOWITZ, Braden Carl ISHLER, William Matthew DICKERSON, Narendra Nath Tandon, Amber Nicole LEE, Glen Michael FITZPATRICK
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Patent number: 11752468Abstract: Provided herein are materials and methods for the preparation of blood products. In one aspect, provided herein is a composition including platelets or platelet derivatives and an aqueous medium, wherein the aqueous medium has a protein concentration less than 50% of the protein concentration of donor apheresis plasma.Type: GrantFiled: November 16, 2022Date of Patent: September 12, 2023Assignee: Cellphire, Inc.Inventors: Joshua Donald Montgomery, Braden Carl Ishler, Stephen Edward Amos, Keith Andrew Moskowitz, Amber Nicole Lee, Rafael Jorda, Glen Michael Fitzpatrick, Michael Alexander Mathews
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Publication number: 20230248771Abstract: In some embodiments provided herein is a method of preparing cargo-loaded platelets, comprising: treating platelets with a cargo and with a loading buffer comprising a salt, a base, a loading agent, and optionally ethanol, to form the cargo-loaded platelets.Type: ApplicationFiled: April 7, 2023Publication date: August 10, 2023Applicant: Cellphire, Inc.Inventors: Keith Andrew MOSKOWITZ, Rafael JORDA, Ying Yi ZHENG, Daniel Allen Sheik
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Publication number: 20230248772Abstract: Compositions and methods for providing one or more platelet-derived hemostatic agents to a treatment site are provided. Compositions and methods may be directed to bandages, carrier materials, and closure devices. Compositions and methods may be directed to treatment of neoplasias, including cancers. The platelet-derived hemostatic agents may include chemotherapeutic agents.Type: ApplicationFiled: April 17, 2023Publication date: August 10, 2023Applicant: Cellphire, Inc.Inventor: Stephen H. Willard
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Publication number: 20230226493Abstract: Provided herein are materials and methods for the preparation of blood products. In one aspect, provided herein is a composition including platelets or platelet derivatives and an aqueous medium, wherein the aqueous medium has a protein concentration less than 50% of the protein concentration of donor apheresis plasma.Type: ApplicationFiled: November 16, 2022Publication date: July 20, 2023Applicant: Cellphire, Inc.Inventors: Joshua Donald MONTGOMERY, Braden Carl ISHLER, Stephen Edward AMOS, Keith Andrew MOSKOWITZ, Amber Nicole LEE, Rafael JORDA, Glen Michael FITZPATRICK, Michael Alexander MATHEWS
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Patent number: 11701388Abstract: In some embodiments provided herein is a method of treating a coagulopathy in a subject, the method including administering to the subject in need thereof an effective amount of a composition including platelets or platelet derivatives and an incubating agent including one or more salts, a buffer, optionally a cryoprotectant, and optionally an organic solvent, wherein the subject has been treated or is being treated with an antiplatelet agent.Type: GrantFiled: August 14, 2020Date of Patent: July 18, 2023Assignee: Cellphire, Inc.Inventors: Keith Andrew Moskowitz, Braden Carl Ishler, William Matthew Dickerson, Narendra Nath Tandon, Amber Nicole Lee, Glen Michael Fitzpatrick
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Publication number: 20230158455Abstract: Provided herein are materials and methods for the preparation of blood products. In one aspect, provided herein is a composition including platelets or platelet derivatives and an aqueous medium, wherein the aqueous medium has a protein concentration less than 50% of the protein concentration of donor apheresis plasma.Type: ApplicationFiled: January 20, 2023Publication date: May 25, 2023Applicant: Cellphire, Inc.Inventors: Joshua Donald MONTGOMERY, Braden Carl ISHLER, Stephen Edward AMOS, Keith Andrew MOSKOWITZ, Amber Nicole LEE, Rafael JORDA, Glen Michael FITZPATRICK, Michael Alexander MATHEWS
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Publication number: 20230149467Abstract: Provided herein are materials and methods for the preparation of blood products. In some aspects, provided herein are compositions that include populations of platelet derivatives, including freeze-dried platelet derivatives, methods of producing the same, as well as methods of using the same to treat a subject. Such platelet derivatives have improved properties, as disclosed herein.Type: ApplicationFiled: November 4, 2022Publication date: May 18, 2023Applicant: Cellphire, Inc.Inventors: Joshua Donald MONTGOMERY, Braden Carl ISHLER, Stephen Edward AMOS, Keith Andrew MOSKOWITZ, Amber Nicole LEE, Rafael JORDA, Glen Michael FITZPATRICK, Michael Alexander MATHEWS
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Publication number: 20230149468Abstract: Provided herein are methods and compositions using extracellular vesicles derived from fresh, frozen, or lyophilized platelets.Type: ApplicationFiled: November 15, 2022Publication date: May 18, 2023Applicant: Cellphire, Inc.Inventors: Ben ANTEBI, Keith Andrew MOSKOWITZ, Stephen Edward AMOS, Michael Alexander MATHEWS, Benjamin J. KUHN, William Matthew DICKERSON, Braden Carl ISHLER, Daniel Allen SHEIK
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Publication number: 20230112136Abstract: The present disclosure provides dry and liquid compositions that include canine platelets and/or canine platelet-derived substances in dried form or rehydrated form from a dried form of canine platelets and/or canine platelet-derived substances, as well as processes for preparing such compositions. The disclosure also provides processes for making the compositions and methods of using the compositions for therapeutic, prophylactic, diagnostic, and research purposes, and kits comprising the compositions.Type: ApplicationFiled: December 2, 2022Publication date: April 13, 2023Applicant: Cellphire, Inc.Inventors: Rafael JORDA, Anne S. Hale, Braden Carl ISHLER, Keith Andrew MOSKOWITZ
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Patent number: 11529587Abstract: Provided herein are materials and methods for the preparation of blood products. In one aspect, provided herein is a composition including platelets or platelet derivatives and an aqueous medium, wherein the aqueous medium has a protein concentration less than 50% of the protein concentration of donor apheresis plasma.Type: GrantFiled: May 1, 2020Date of Patent: December 20, 2022Assignee: Cellphire, Inc.Inventors: Joshua Donald Montgomery, Braden Carl Ishler, Stephen Edward Amos, Keith Andrew Moskowitz, Amber Nicole Lee, Rafael Jorda, Glen Michael Fitzpatrick, Michael Alexander Mathews
