Abstract: The present invention generally relates to systems and methods for determining the probability of a pregnancy at a selected point in time. Systems and methods of the invention employ an algorithm that has been trained on a reference set of data from a plurality of women for whom at least one of fertility-associated phenotypic traits, fertility-associated medical interventions, or pregnancy outcomes are known, in which the algorithm accounts for any woman who ceases pregnancy attempts prior to reaching a live birth outcome.
Type:
Grant
Filed:
September 18, 2015
Date of Patent:
March 3, 2020
Assignee:
CELMATIX, INC.
Inventors:
Michael Elashoff, Hrishikesh Karvir, Piraye Yurttas Beim
Abstract: The present invention generally relates to systems and methods for determining the probability of a pregnancy at a selected point in time. Systems and methods of the invention employ an algorithm that has been trained on a reference set of data from a plurality of women for whom at least one of fertility-associated phenotypic traits, fertility-associated medical interventions, or pregnancy outcomes are known, in which the algorithm accounts for any woman who ceases pregnancy attempts prior to reaching a live birth outcome.
Type:
Grant
Filed:
September 18, 2015
Date of Patent:
July 2, 2019
Assignee:
CELMATIX, INC.
Inventors:
Michael Elashoff, Hrishikesh Karvir, Piraye Yurttas Beim
Abstract: Methods for assessing infertility and related pathologies and informing treatment type and timing thereof are provided. According to certain embodiments, methods of the invention include determining levels of one or more transcripts present in a sample obtained from a subject suspected of having endometriosis, identifying transcript levels that correspond to a regulation pattern specific to a time-point in a uterine cycle, and characterizing endometriosis of the subject based upon the identified transcript levels. The invention includes methods for assessing age-associated increase in aneuploidy rates based on FSH levels and IVF success rates based on obesity in PCOS patients.
Type:
Grant
Filed:
July 17, 2015
Date of Patent:
February 19, 2019
Assignee:
Celmatix Inc.
Inventors:
Piraye Yurttas Beim, David Emlyn Parfitt, Michael Elashoff
Abstract: The present invention generally relates to systems and methods for determining the probability of a pregnancy at a selected point in time. Systems and methods of the invention employ an algorithm that has been trained on a reference set of data from a plurality of women for whom at least one of fertility-associated phenotypic traits, fertility-associated medical interventions, or pregnancy outcomes are known, in which the algorithm accounts for any woman who ceases pregnancy attempts prior to reaching a live birth outcome.
Type:
Grant
Filed:
October 11, 2013
Date of Patent:
December 25, 2018
Assignee:
Celmatix Inc.
Inventors:
Michael Elashoff, Hrishikesh Karvir, Piraye Yurttas Beim
Abstract: The invention generally relates to methods and devices for assessing risk of female infertility. In certain aspects, methods of the invention involve obtaining a sample, conducting an assay on at least one infertility-associated biomarker, and assessing risk to the patient of developing early-onset decrease in fertility based upon results of the assay.
Abstract: The present invention generally relates to systems and methods for determining the probability of a pregnancy at a selected point in time. Systems and methods of the invention employ an algorithm that has been trained on a reference set of data from a plurality of women for whom at least one of fertility-associated phenotypic traits, fertility-associated medical interventions, or pregnancy outcomes are known, in which the algorithm accounts for any woman who ceases pregnancy attempts prior to reaching a live birth outcome.
Type:
Grant
Filed:
October 17, 2012
Date of Patent:
November 3, 2015
Assignee:
Celmatix Inc.
Inventors:
Michael Elashoff, Hrishikesh Karvir, Piraye Yurttas Beim
Abstract: The invention generally relates to methods and devices for assessing risk of female infertility. In certain aspects, methods of the invention involve obtaining a sample, conducting an assay on at least one infertility-associated biomarker, and assessing risk to the patient of developing early-onset decrease in fertility based upon results of the assay.
Abstract: The present invention generally relates to systems and methods for determining the probability of a pregnancy at a selected point in time. Systems and methods of the invention employ an algorithm that has been trained on a reference set of data from a plurality of women for whom at least one of fertility-associated phenotypic traits, fertility-associated medical interventions, or pregnancy outcomes are known, in which the algorithm accounts for any woman who ceases pregnancy attempts prior to reaching a live birth outcome.
Type:
Application
Filed:
October 11, 2013
Publication date:
April 17, 2014
Applicant:
CELMATIX, INC.
Inventors:
Michael Elashoff, Hrishikesh Karvir, Piraye Yurttas Beim
Abstract: The invention generally relates to methods and devices for assessing infertility. In certain embodiments, methods of the invention involve conducting an assay to determine presence or absence of a mutation in a plurality of genes selected from Table 1, and assessing infertility based on results of the assay, wherein presence of a mutation in at least two of the genes from Table 1 is indicative of infertility.
Abstract: The invention generally relates to methods and devices for assessing infertility. In certain embodiments, methods of the invention involve conducting an assay to determine presence or absence of a mutation in a plurality of genes selected from Table 1, and assessing infertility based on results of the assay, wherein presence of a mutation in at least two of the genes from Table 1 is indicative of infertility.