Abstract: The present invention relates to pharmaceutical and food compositions for inducing satiation and prolonging satiety in subjects in need thereof. In particular, the present invention relates to a method of inducing satiation in a subject in need thereof comprising administering to the subject an effective amount of a ClpB protein or an effective amount of a bacterium that expresses the ClpB protein.

Abstract: The inventors demonstrate that the phosphatase and hydrolase domains of soluble epoxide hydrolase (sEH) regulate the cardiovascular calcification process and revealed that inhibition of the phosphatase domain of sEH could represent a new pharmacological target in the prevention of cardiovascular calcification. The present invention thus relates to a therapeutically effective amount of an inhibitor of phosphatase activity of soluble epoxide hydrolase for use in a method of treating cardiovascular calcification in a subject in need thereof.

Abstract: The present invention relates to method of preventing, treating or attenuating obesity-related manifestations in a human or non-human mammal subject in need thereof, said method comprising orally administering to the subject a composition comprising an effective amount Hafnia alvei probiotics; wherein said obesity-related parameters are selected from the group of hyperphagia, increased fat mass on lean mass ratio, increased waist circumference, postprandial hyperglycemia, fasting hyperglycemia and hypercholesterolemia.

Abstract: A composition essentially made of a Hafnia alvei probiotic strain expressing the ClpB protein; wherein the ClpB protein is in an amount of at least 0.7% (w/w) in weight relative to the total weight of the composition; and the ratio of the total number of Hafnia alvei Colony Forming Units to the total Hafnia alvei cell number ranges from 10?4 to 0.8. Also, oral dosage forms, namely gastro-resistant capsules including the composition of essentially made of a Hafnia alvei probiotic strain expressing the ClpB protein.

Abstract: The present invention provides a method for the diagnosis of disorders caused by foetal alcohol syndrome, said method comprising the assaying of PLGF (placental growth factor).

Abstract: The present invention relates to ClpB expressing bacteria and their impact on obesity. The present invention relates to bacterial ClpB protein and ClpB expressing bacteria and their impact on eating disorders. The invention further relates to compositions comprising antibiotic directed against at least one ClpB expressing bacterium as well as probiotics not expressing ClpB protein and their use in the treatment or prevention of eating disorders. The invention also relates to diagnostic tools for determining whether a subject is likely to respond to a method of treating eating disorders and to methods of immunization against eating disorders.

Abstract: The present invention relates to pharmaceutical and food compositions for inducing satiation and prolonging satiety in subjects in need thereof. In particular, the present invention relates to a method of inducing satiation in a subject in need thereof comprising administering to the subject an effective amount of a ClpB protein or an effective amount of a bacterium that expresses the ClpB protein.

Abstract: The invention relates to a placental growth factor (PlGF) to be used as a drug in the prevention and/or treatment of fetal alcohol syndrome disorders (FASD) selected from the group comprising fetal alcohol syndrome (FAS), cerebrovascular disease, and growth retardation in a subject exposed to alcohol in utero. The invention also relates to a pharmaceutical composition or a product comprising the PlGF for the same therapeutic uses.

Abstract: The present invention provides a method for the diagnosis of disorders caused by foetal alcohol syndrome, said method comprising the assaying of PLGF (placental growth factor).

Abstract: The present invention relates to pharmaceutical and food compositions for inducing satiation and prolonging satiety in subjects in need thereof. In particular, the present invention relates to a method of inducing satiation in a subject in need thereof comprising administering to the subject an effective amount of a ClpB protein or an effective amount of a bacterium that expresses the ClpB protein.

Abstract: An endo-urethral prosthesis characterized in that it comprises a set of guides (100) defining an internal space (201) in a urinary channel, and one or more support elements (110) for supporting the internal wall of the urinary tract, the guides comprising recessed areas and protruding areas, said protruding areas forming locking regions (21) for holding the support elements in place, in a position that allows them to support the internal wall of the urinary tract.

Abstract: The invention relates to methods and means for predicting rheumatoid arthritis treatment response.

Abstract: The present invention relates to antibodies which bind human ghrelin and their use in methods of treating or preventing reduced appetite. The invention further relates to diagnostic tools for determining whether an individual is likely to respond to a method of treating or preventing reduced appetite.

Abstract: The present invention concerns particles containing at least one covalently cross-linked polysaccharide and at least one growth factor, a method of preparation, and uses thereof.

Abstract: The invention concerns an electrical connection device (1) designed to be implanted inside an animal's body to provide an electrical connection between several electrical wires, characterized in that it comprises: a housing (10) comprising at least one opening (11) formed at the surface of said housing (10) at the end of at least one cavity formed inside the housing (10), said cavity being designed to receive a first electrical wire through opening (11); electrical interconnection means (8) to establish an electrical connection between said first electrical wire and at least one second electrical wire; a means for maintaining the position of the first electrical wire in the corresponding cavity, said position maintenance means having a cam (13) rotatably mounted in the housing to compress said first electrical wire against the inner walls of the cavity during rotation of cam (13) in a direction tending to insert said first electrical wire inside the corresponding cavity.

Abstract: The invention relates to an instrument for preparing an corneal endothelial graft, the tool being a trephine blade (1) having a cross section in the form of an arc of a circle of between 270° and 355°. The invention also relates to a method of preparing a graft using such an instrument.

Abstract: The invention concerns an electrical connection system for a percutaneous electrical connection between an electrical device (2) inside an animal body and an electrical device (3) outside said body, comprising a subcutaneous device (10) designed to be connected to internal electrical device (2), said subcutaneous device (10) comprising: an open housing (11) having at least one inner compartment (12), said compartment (12) being filled with a conductive material into which an electrical connection plug can be inserted, the conductive material of compartment (12) being further connected to connection means (5) designed to be connected to internal electrical device (2); a sealing membrane (13) for sealing housing (11), said sealing membrane (13) being formed of an insulating and flexible material designed for insertion of electrical connection plugs from outside housing (11) through said sealing membrane (13) to the conductive material of compartment (12); characterized in that housing (11) comprises alignme

Abstract: An electrical connection system to electrically connect an internal electrical device (2) positioned inside an animal's body with an external electrical device (3) positioned outside the animal's body. The system includes a cable (4) positioned at least partially inside the animal's body and enclosing at least one electrical wire. The cable (4) has at one end a first connector (5) to connect the at least one electrical wire with an external electrical device (3). The cable (4) has at its other end a second connector (1) placed inside the animal's body. The second connector (1) has connectors to allow an electrical connection between the at least one cable (4) and the internal electrical device (2). The second connector (1) includes additional connectors to allow a removable electrical connection between at least one electrical wire external to the cable (4) and the internal electrical device (2).

Abstract: Constitution of a suburethral sling connected to two balloons located on each side of the urethra. The device preferably consists of two subassemblies (12a and 12b) each comprising an inflatable balloon (13) and a strip (16) one end of which is attached to the surface of the balloon. The two strips (16) are connected together to form a suburethral sling.

Abstract: Constitution of a suburethral sling connected to two balloons located on each side of the urethra.