Abstract: The invention relates to a method and the associated device 1 for separating one or more particular digital audio source signals (si) contained in a mixed multichannel digital audio signal (smix) obtained by mixing a plurality of digital audio source signals (s1, . . . , sp). According to the invention: the modulus of the amplitude or the normalized power of the particular source signal(s) (si) is determined from representative values of said particular source signal(s) contained in the mixed signal; and then linearly constrained minimum variance spatial filtering is performed on the mixed signal in order to obtain each particular source signal (s?i), said filtering being based on the distribution of said particular source signal between at least two channels of the mixed signal, and the modulus of the amplitude or the normalized power of said particular source signal is used as a linear constraint of the filter.

Abstract: The subject matter of the present disclosure relates to an in vitro method for the screening of anti-cancer compounds based on the capacity for these compounds to interact with neurotrophin 3 (NT-3 or NT3), to the extracellular domain, or TrkC receptor and/or to inhibit the dimerization of the intracellular domain of the TrkC receptor expressed in tumor cells, particularly in neuroblastoma. The disclosure also relates to a method for predicting the presence of metastatic cancer or a bad prognosis cancer, or for determining the efficiency of an anti-cancer treatment based on the measuring of the expression level of neurotrophin 3. The disclosure further comprises kits and compounds as a medicament for the treatment of neuroblastoma or cancer overexpressing neurotrophin 3 by the tumor cells.

Abstract: The invention relates to transgenic aquatic animals, particularly the clawed frog and the zebra fish and cells derived therefrom, characterised in comprising at least one expression cassette with a regulatory DNA sequence selected from the response elements to nuclear hormone receptors, particularly TRE, connected in a functional manner downstream of a DNA segment coding for a marker protein such as luciferase or GFP. The invention further relates to methods using the transgenic cells and animals according to the invention for the identification of endocrine disrupters in the environment.