Patents Assigned to Centre National de Recherche Scientifique
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Publication number: 20200386670Abstract: The present invention relates to a set-up and a method for measuring color of a turbid liquid giving a result matching a visual observation.Type: ApplicationFiled: December 20, 2018Publication date: December 10, 2020Applicants: CHR. HANSEN NATURAL COLORS A/S, UNIVERSITE MONTPELLIER, CENTRE NATIONAL DE RECHERCHE SCIENTIFIQUEInventors: Frederic GENIET, Stephanie VUILLEMOT-KESENNE, Maeva GARDON-CHAPELET
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Patent number: 9802061Abstract: The disclosure is related to an apparatus and method for charged hadron therapy verification. The apparatus comprises a collimator comprising a plurality of collimator slabs of a given thickness, spaced apart so as to form an array of mutually slit-shaped openings, configured to be placed at a right angle to the beam line, so as to allow the passage of prompt gammas from the target, the collimator being defined at least by three geometrical parameters being the width and depth of the slit-shaped openings and a fill factor. The disclosure is also related to a method for charged hadron therapy verification with a multi-slit camera.Type: GrantFiled: May 8, 2015Date of Patent: October 31, 2017Assignees: Ion Beam Applications S.A., Université Claude Bernard Lyon 1, Institut National des Science Appliquées de Lyon, Centre National de Recherche Scientifique (CNRS)Inventors: Nicolas Freud, Frauke Roellinghoff, Etienne Testa, Marco Pinto, Julien Smeets
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Patent number: 9632121Abstract: The present invention relates to electronic power converter suitable, in a first mode, for receiving electrical voltage and/or current magnitudes from a first device as input, for processing them using processing means capable of measuring said electrical magnitudes and servocontrolling said electrical magnitudes based on said measurements and constraints specific to a second device, and for providing the adapted voltage and/or current magnitudes to said second device.Type: GrantFiled: May 15, 2012Date of Patent: April 25, 2017Assignees: CENTRE NATIONAL DE RECHERCHE SCIENTIFIQUE, UNIVERSITE DE FRANCHE-COMTEInventors: Daniel Depernet, Oumar Ba, Alain Berthon
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Patent number: 9566558Abstract: The present invention concerns a microfluidic device (1) for performing physical, chemical or biological treatment to at least one packet without contamination.Type: GrantFiled: September 9, 2005Date of Patent: February 14, 2017Assignees: INSTITUT CURIE, CENTRE NATIONAL DE RECHERCHE SCIENTIFIQUEInventors: Jean-Louis Viovy, Max Chabert, Kevin Dorfman
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Publication number: 20160319306Abstract: The present invention relates, inter alia, to recombinant Gram-positive Clostridia host cells for producing solvents, fuels and/or chemical intermediates, and preferably ethanol, from plant cell walls comprising: (a) at least one nucleic acid encoding a plant cell wall degrading enzyme, wherein the host cells produce and secrete the plant cell wall degrading enzyme, (b) at least one nucleic acid encoding an enzyme that converts pyruvate to acetaldehyde and at least one nucleic acid encoding an enzyme that converts acetaldehyde to ethanol wherein the host cell is capable of expressing said nucleic acid, and, (c) a mutation in at least one nucleic acid encoding for an enzyme in a metabolic pathway which produces a metabolite other than acetaldehyde from pyruvate or ethanol from acetaldehyde, such that the mutation results in a reduced production of the metabolite.Type: ApplicationFiled: June 24, 2016Publication date: November 3, 2016Applicants: Total Marketing Services, Le Centre National De Recherche Scientifique (CNRS), Université D'Aix Marseille, L'Institut National des Sciences Appliquées (INSA)Inventors: Laurence GIRBAL, Florence Saint-Prix, Mathieu Cesari, Henri-Pierre Fierobe, Roberto Mazzoli, Florence Mingardon, Angélique Chanal-Vial
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Patent number: 9441213Abstract: Described herein are molecules, constructs and methods for the production and secretion of polypeptides of interest by host cells, preferably bacterial host cells, and more particularly gram positive bacteria. In particular, the present invention is related to a polynucleic acid encoding a fusion protein and to uses thereof for the secretion of heterologous or homologous polypeptides of interest by a bacterial host cell, preferably Clostridium bacteria. The present invention further relates to methods and constructs for the production and secretion of heterologous or homologous polypeptides of interest proteins by host cells using such polynucleic acids and fusion proteins.Type: GrantFiled: April 9, 2014Date of Patent: September 13, 2016Assignees: Total Marketing Services, Le Centre National De Recherche Scientifique (CNRS), Université d'Aix-Marseille, L'Institut National des Sciences Appliquées (INSA)Inventors: Henri-Pierre Fierobe, Florence Mingardon, Angélique Chanal-Vial
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Patent number: 9382306Abstract: The present invention relates to novel octapeptide compounds of general formula (I): H-2-Nal 1-cyclo(Cys2-Tyr3-AA4-Lys5-Val6-Cys7)-Thr8-NH2. Since these products have a good affinity for certain somatostatin receptor subtypes, they are particularly advantageous for treating pathological states or diseases in which one (or more) somatostatin receptor(s) is (are) involved. These compounds furthermore have physiochemical properties that make it possible to envisage them in diverse solutions for the formulation of medicaments, for example as a pharmaceutically acceptable carrier. The invention also relates to pharmaceutical compositions containing said products and to the use thereof for the preparation of a medicament.Type: GrantFiled: September 29, 2009Date of Patent: July 5, 2016Assignees: IPSEN PHARMA S.A.S., COMMISSARIAT A L'ENERGIE ATOMIQUE (CEA), LE CENTRE NATIONAL DE RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Marie-Thérèse Paternostre, Jean-Christophe Cintrat, Céline Valery, Stéphane Roux, Bernard Rousseau, Maarten Ijsselstijn, Roland Cherif-Cheikh, Franck Artzner
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Patent number: 9107884Abstract: The invention provides methods of treating diseases, disorsers or injuries involving demyelination and dysmyelination, including multiple sclerosis, by the administration of a Sema6A polypeptide.Type: GrantFiled: February 4, 2008Date of Patent: August 18, 2015Assignees: BIOGEN MA INC., CENTRE NATIONAL DE RECHERCHE SCIENTIFIQUEInventors: Alain Chedotal, Sha Mi, Frederic Bernard
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Publication number: 20140373550Abstract: The invention relates to a rear casing for a turbine engine comprising a primary body generating a primary flow (10) to be ejected through a primary nozzle (6), said rear casing (7) being shaped so as to be positioned downstream from the primary body and to define, on the inside of the turbine engine, the path followed by the primary flow downstream from the primary nozzle (6). The tail cone is characterised in that it comprises a connection to a system for supplying a pressurised gas and at least one perforation (8) for injecting the pressurised gas through the perforation and into the primary flow. The casing preferably comprises at least one means for rotating same about the axis of rotation of the mobile elements of the primary body.Type: ApplicationFiled: July 8, 2014Publication date: December 25, 2014Applicants: SNECMA, Centre National De Recherche Scientifique (CNRS), UNIVERSITE DE POITIERS, ENSMAInventors: Alexandre Alfred Gaston VUILLEMIN, Maxime KOENIG, Peter JORDAN, Pierre COMTE, Yves GERVAIS
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Patent number: 8906268Abstract: A phantom for medical imaging instrumentation, the phantom including a first hydrogel matrix, said matrix containing additives for simulating the optical and acoustic properties of a living organ or tissue. In the phantom, the additives include Indian ink or haemoglobin, silica powder and titanium dioxide powder. The phantom may contain a tumor simulator in solid or liquid form. It may also comprise several hydrogel matrices, each matrix including additives in different concentrations depending on the organ or tissue simulated. A method of producing the phantom includes one or more freeze-thaw cycles for optimizing the characteristics of the phantom.Type: GrantFiled: September 1, 2010Date of Patent: December 9, 2014Assignees: Commissariat a l'Energie Atomique et aux Energies Alternatives, Centre National de Recherche ScientifiqueInventors: Jérôme Boutet, Didier Vray, Nadia Djaker, Laurent Guyon, Laurent Saroul, Denis Friboulet, François Duboeuf
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Patent number: 8871479Abstract: The invention relates to applications of the cellulase Cel5H of Saccharophagus degradans and its homologues, functional fragments and/or variants and engineered forms thereof, in the context of recombinant, more particularly solventogenic microorganisms, more particularly C. acetobutylicum. The invention also characterizes a novel domain of the Cel5H cellulase with a putative cellulose-binding module function, and its uses in chimeric proteins for depolymerization of cellulose containing substrates.Type: GrantFiled: November 26, 2009Date of Patent: October 28, 2014Assignees: Total Marketing Services, Le Centre National de Recherche Scientifiques (CNRS), L'Institut National des Sciences Appliquees (INSA), Universite d'Aix-MarseilleInventors: Henri-Pierre Fierobe, Angélique Chanal-Vial, Anne-Laure Molinier, Chantal Tardif, Luc Dedieu
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Patent number: 8815350Abstract: A method for grafting a porous element for leucodepletion by adsorption and/or filtration of a biological fluid, such as blood or a blood component, which method comprises the steps of impregnating the porous element with a solution containing a poly(ethylene oxide) having identical or different functional end groups; and applying an ionizing treatment to the impregnated porous element so as to ensure covalent cross-linking between the poly(ethylene oxide) and the porous element.Type: GrantFiled: December 18, 2008Date of Patent: August 26, 2014Assignees: Maco Pharma Societe Anonyme, Centre National de Recherche ScientifiqueInventors: Pascal Marmey, Emilie Bessy, Pierre Lutz, Gregory Henard
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Publication number: 20140193127Abstract: According to the invention, the intermediate sheath (13) is formed by assembling longitudinal elements (13A) and includes: a first optical material, the refractive index of which differs from the refractive index of the monomode core by at most 10?3; and a second optical material, the refractive index of which is lower than the refractive index of said monomode core and differs therefrom by at least 10?3.Type: ApplicationFiled: April 24, 2012Publication date: July 10, 2014Applicants: UNIVERSITE DE LIMOGES, CNRS-CENTRE NATIONAL DE RECHERCHE SCIENTIFIQUEInventors: Philippe Roy, Kay Schuster, Stephan Grimm
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Publication number: 20140155436Abstract: The present invention relates to a compound of one of the formulas I to XXI; a pharmaceutical composition comprising at least one such compound; and the use of at least one such compound in preparing a drug to treat, in a subject, a genetic disease resulting from at least one splicing anomaly.Type: ApplicationFiled: November 4, 2013Publication date: June 5, 2014Applicants: CENTRE NATIONAL DE RECHERCHE SCIENTIFIQUE, UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES, INSTITUT CURIEInventors: Jamal TAZI, David GRIERSON, Florence MAHUTEAU-BETZER, Pierre ROUX
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Patent number: 8634229Abstract: A memory cell is provided with a transistor which includes source and drain electrodes formed in a semiconductor film by respectively N-doped and P-doped areas. The transistor includes first and second devices for generating a potential barrier in the semiconductor film. The two potential barriers are shifted laterally and are opposed to the passage of the charge carriers emitted by the nearest source/drain electrode. One of the devices for generating the potential barrier is electrically connected to the gate. The other of the devices for generating the potential barrier is electrically connected to the counter-electrode. The writing of a high state is carried out by imposing on the P-doped electrode a potential higher than that of the N-doped electrode and charging the capacitor formed between the gate and the semiconductor film. The resetting of the memory cell is obtained by discharging the capacitor.Type: GrantFiled: October 22, 2012Date of Patent: January 21, 2014Assignees: Commissariat a l'Energie Atomique et aux Energies Alternatives, Centre National de Recherche ScientifiqueInventors: Jing Wan, Sorin Cristoloveanu, Cyrille Le Royer, Alexander Zaslavsky
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Patent number: 8604201Abstract: The invention relates to the use of cyclovinyl phosphine compounds in the form of complexes with copper, as catalysts for reactions leading to the formation of carbon-carbon and carbon-heteroatom bonds. The invention also relates to complexes of copper with at least one cyclovinyl phosphine, as well as to the method for creating a carbon-carbon or a carbon-heteroatom bond catalysed by a cyclovinyl phosphine/copper complex.Type: GrantFiled: September 26, 2008Date of Patent: December 10, 2013Assignee: Centre National de Recherche Scientifique (C.N.R.S.)Inventors: Marc Taillefer, Hamid Kaddouri, Fouad Ouazzani
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Patent number: 8604063Abstract: The present invention relates to a compound of one of the formulas I to XXI; a pharmaceutical composition comprising at least one such compound; and the use of at least one such compound in preparing a drug to treat, in a subject, a genetic disease resulting from at least one splicing anomaly.Type: GrantFiled: January 12, 2009Date of Patent: December 10, 2013Assignees: Centre National de Recherche Scientifique, Institut Curie, Universite Montpellier 2 sciences et TechniquesInventors: Jamal Tazi, David Grierson, Florence Mahuteau-Betzer, Pierre Roux
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Patent number: 8492445Abstract: An emulsifying composition, characterised in that it contains by weight, excluding impurities, (i) 1 to 98% by weight of a mixture of alkyl glycosides R1O(G1)g1(G2)g2(G3)g3(G4)g4(G5)g5, (ii) 1 to 90% by weight of a mixture of alcohol esters R2OZ, (iii) 1 to 90% of an alcohol R3OH, and (iv) 4 to 90% of a mixture of alkyl glycoside esters R4O(X1)x1(Z)z1(X2)x2(Z)z2(X3)x3(Z)z3(X4)x4(Z)z4(X5)x5(Z)z5, is disclosed In accordance with the composition, R1 is a hydrocarbon radical, linear or branched, saturated or unsaturated, having 10 to 22 carbon atoms. G1, G2, G3, G4, G5 are identical or different residues of -oses selected from glucose, galactose, mannose, fructose, ribose, xylose and arabinose, g1, g2, g3, g4 and g5 being equal to 0 or 1, the sum of g1, g2, g3, g4 and g5 being at least equal to 1. The composition has emulsifying capacity in the presence of electrolytes or in the case of paraffin-based emulsions.Type: GrantFiled: March 4, 2010Date of Patent: July 23, 2013Assignees: Bioamber SAS, Universite de Reims Champagne Ardenne (U.R.C.A.), Centre National de Recherche Scientifique (C.N.R.S.)Inventors: Benjamin Renault, Boris Estrine, Charles Portella, Cedric Ernenwein, Fabien Massicot, Sinisa Marinkovic
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Patent number: 8462031Abstract: Continuous time analogue/digital converter, comprising a sigma delta modulator (MSD1) configured to receive an analogue input signal (x(t)) and comprising high-pass filtering means (MF) the chopping frequency of which is equal to half of the sampling frequency (Fs) of the quantization means (QTZ) of the modulator (MSD1).Type: GrantFiled: February 10, 2011Date of Patent: June 11, 2013Assignees: STMicroelectronics SA, Centre National de Recherche Scientifique (CNRS)Inventors: Didier Belot, Jean-Baptiste Begueret, Yann Deval, Dominique Dallet, André Mariano
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Publication number: 20130115669Abstract: The present invention relates, inter alia, to recombinant Gram-positive Clostridia host cells for producing solvents, fuels and/or chemical intermediates, and preferably ethanol, from plant cell walls comprising: (a) at least one nucleic acid encoding a plant cell wall degrading enzyme, wherein the host cells produce and secrete the plant cell wall degrading enzyme, (b) at least one nucleic acid encoding an enzyme that converts pyruvate to acetaldehyde and at least one nucleic acid encoding an enzyme that converts acetaldehyde to ethanol wherein the host cell is capable of expressing said nucleic acid, and, (c) a mutation in at least one nucleic acid encoding for an enzyme in a metabolic pathway which produces a metabolite other than acetaldehyde from pyruvate or ethanol from acetaldehyde, such that the mutation results in a reduced production of the metabolite.Type: ApplicationFiled: January 9, 2013Publication date: May 9, 2013Applicants: Total S.A., Le Centre National De Recherche Scientifique (CNRS, L'Institut National des Sciences Appliquées (INSA), L'Université de Provence, L'Université de la MediterranéeInventors: Laurence GIRBAL, Florence Saint-Prix, Mathieu Cesari, Henri-Pierre Fierobe, Roberto Mazzoli, Florence Mingardon, Angélique Chanal-Vial