Patents Assigned to Centre National De Recherche Scientifique (CNRS)
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Patent number: 9802061Abstract: The disclosure is related to an apparatus and method for charged hadron therapy verification. The apparatus comprises a collimator comprising a plurality of collimator slabs of a given thickness, spaced apart so as to form an array of mutually slit-shaped openings, configured to be placed at a right angle to the beam line, so as to allow the passage of prompt gammas from the target, the collimator being defined at least by three geometrical parameters being the width and depth of the slit-shaped openings and a fill factor. The disclosure is also related to a method for charged hadron therapy verification with a multi-slit camera.Type: GrantFiled: May 8, 2015Date of Patent: October 31, 2017Assignees: Ion Beam Applications S.A., Université Claude Bernard Lyon 1, Institut National des Science Appliquées de Lyon, Centre National de Recherche Scientifique (CNRS)Inventors: Nicolas Freud, Frauke Roellinghoff, Etienne Testa, Marco Pinto, Julien Smeets
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Publication number: 20160319306Abstract: The present invention relates, inter alia, to recombinant Gram-positive Clostridia host cells for producing solvents, fuels and/or chemical intermediates, and preferably ethanol, from plant cell walls comprising: (a) at least one nucleic acid encoding a plant cell wall degrading enzyme, wherein the host cells produce and secrete the plant cell wall degrading enzyme, (b) at least one nucleic acid encoding an enzyme that converts pyruvate to acetaldehyde and at least one nucleic acid encoding an enzyme that converts acetaldehyde to ethanol wherein the host cell is capable of expressing said nucleic acid, and, (c) a mutation in at least one nucleic acid encoding for an enzyme in a metabolic pathway which produces a metabolite other than acetaldehyde from pyruvate or ethanol from acetaldehyde, such that the mutation results in a reduced production of the metabolite.Type: ApplicationFiled: June 24, 2016Publication date: November 3, 2016Applicants: Total Marketing Services, Le Centre National De Recherche Scientifique (CNRS), Université D'Aix Marseille, L'Institut National des Sciences Appliquées (INSA)Inventors: Laurence GIRBAL, Florence Saint-Prix, Mathieu Cesari, Henri-Pierre Fierobe, Roberto Mazzoli, Florence Mingardon, Angélique Chanal-Vial
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Patent number: 9441213Abstract: Described herein are molecules, constructs and methods for the production and secretion of polypeptides of interest by host cells, preferably bacterial host cells, and more particularly gram positive bacteria. In particular, the present invention is related to a polynucleic acid encoding a fusion protein and to uses thereof for the secretion of heterologous or homologous polypeptides of interest by a bacterial host cell, preferably Clostridium bacteria. The present invention further relates to methods and constructs for the production and secretion of heterologous or homologous polypeptides of interest proteins by host cells using such polynucleic acids and fusion proteins.Type: GrantFiled: April 9, 2014Date of Patent: September 13, 2016Assignees: Total Marketing Services, Le Centre National De Recherche Scientifique (CNRS), Université d'Aix-Marseille, L'Institut National des Sciences Appliquées (INSA)Inventors: Henri-Pierre Fierobe, Florence Mingardon, Angélique Chanal-Vial
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Patent number: 9382306Abstract: The present invention relates to novel octapeptide compounds of general formula (I): H-2-Nal 1-cyclo(Cys2-Tyr3-AA4-Lys5-Val6-Cys7)-Thr8-NH2. Since these products have a good affinity for certain somatostatin receptor subtypes, they are particularly advantageous for treating pathological states or diseases in which one (or more) somatostatin receptor(s) is (are) involved. These compounds furthermore have physiochemical properties that make it possible to envisage them in diverse solutions for the formulation of medicaments, for example as a pharmaceutically acceptable carrier. The invention also relates to pharmaceutical compositions containing said products and to the use thereof for the preparation of a medicament.Type: GrantFiled: September 29, 2009Date of Patent: July 5, 2016Assignees: IPSEN PHARMA S.A.S., COMMISSARIAT A L'ENERGIE ATOMIQUE (CEA), LE CENTRE NATIONAL DE RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Marie-Thérèse Paternostre, Jean-Christophe Cintrat, Céline Valery, Stéphane Roux, Bernard Rousseau, Maarten Ijsselstijn, Roland Cherif-Cheikh, Franck Artzner
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Publication number: 20140373550Abstract: The invention relates to a rear casing for a turbine engine comprising a primary body generating a primary flow (10) to be ejected through a primary nozzle (6), said rear casing (7) being shaped so as to be positioned downstream from the primary body and to define, on the inside of the turbine engine, the path followed by the primary flow downstream from the primary nozzle (6). The tail cone is characterised in that it comprises a connection to a system for supplying a pressurised gas and at least one perforation (8) for injecting the pressurised gas through the perforation and into the primary flow. The casing preferably comprises at least one means for rotating same about the axis of rotation of the mobile elements of the primary body.Type: ApplicationFiled: July 8, 2014Publication date: December 25, 2014Applicants: SNECMA, Centre National De Recherche Scientifique (CNRS), UNIVERSITE DE POITIERS, ENSMAInventors: Alexandre Alfred Gaston VUILLEMIN, Maxime KOENIG, Peter JORDAN, Pierre COMTE, Yves GERVAIS
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Patent number: 8871479Abstract: The invention relates to applications of the cellulase Cel5H of Saccharophagus degradans and its homologues, functional fragments and/or variants and engineered forms thereof, in the context of recombinant, more particularly solventogenic microorganisms, more particularly C. acetobutylicum. The invention also characterizes a novel domain of the Cel5H cellulase with a putative cellulose-binding module function, and its uses in chimeric proteins for depolymerization of cellulose containing substrates.Type: GrantFiled: November 26, 2009Date of Patent: October 28, 2014Assignees: Total Marketing Services, Le Centre National de Recherche Scientifiques (CNRS), L'Institut National des Sciences Appliquees (INSA), Universite d'Aix-MarseilleInventors: Henri-Pierre Fierobe, Angélique Chanal-Vial, Anne-Laure Molinier, Chantal Tardif, Luc Dedieu
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Patent number: 8462031Abstract: Continuous time analogue/digital converter, comprising a sigma delta modulator (MSD1) configured to receive an analogue input signal (x(t)) and comprising high-pass filtering means (MF) the chopping frequency of which is equal to half of the sampling frequency (Fs) of the quantization means (QTZ) of the modulator (MSD1).Type: GrantFiled: February 10, 2011Date of Patent: June 11, 2013Assignees: STMicroelectronics SA, Centre National de Recherche Scientifique (CNRS)Inventors: Didier Belot, Jean-Baptiste Begueret, Yann Deval, Dominique Dallet, André Mariano
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Publication number: 20130115669Abstract: The present invention relates, inter alia, to recombinant Gram-positive Clostridia host cells for producing solvents, fuels and/or chemical intermediates, and preferably ethanol, from plant cell walls comprising: (a) at least one nucleic acid encoding a plant cell wall degrading enzyme, wherein the host cells produce and secrete the plant cell wall degrading enzyme, (b) at least one nucleic acid encoding an enzyme that converts pyruvate to acetaldehyde and at least one nucleic acid encoding an enzyme that converts acetaldehyde to ethanol wherein the host cell is capable of expressing said nucleic acid, and, (c) a mutation in at least one nucleic acid encoding for an enzyme in a metabolic pathway which produces a metabolite other than acetaldehyde from pyruvate or ethanol from acetaldehyde, such that the mutation results in a reduced production of the metabolite.Type: ApplicationFiled: January 9, 2013Publication date: May 9, 2013Applicants: Total S.A., Le Centre National De Recherche Scientifique (CNRS, L'Institut National des Sciences Appliquées (INSA), L'Université de Provence, L'Université de la MediterranéeInventors: Laurence GIRBAL, Florence Saint-Prix, Mathieu Cesari, Henri-Pierre Fierobe, Roberto Mazzoli, Florence Mingardon, Angélique Chanal-Vial
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Publication number: 20130032650Abstract: A method for controlled reduction of the weight average molar mass of a polysaccharide down to a lower and determined weight average molar mass, which method includes a step for mechanical milling of the polysaccharide by a ball mill, until the polysaccharide having the desired weight average molar mass is obtained.Type: ApplicationFiled: November 29, 2010Publication date: February 7, 2013Applicants: CENTRE NATIONAL DE RECHERCHE SCIENTIFIQUE - CNRS, INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER-IFREMER, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6 )Inventors: Claire Boisset, Tinaig Le Costaouec, Joelle Cozien, Corinne Sinquin, Jacqueline Ratiskol, William Helbert, Gaelle Correc, Veronique Larreta Garde
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Publication number: 20120122176Abstract: The invention relates to applications of the cellulase Cel5H of Saccharophagus degradans and its homologues, functional fragments and/or variants and engineered forms thereof, in the context of recombinant, more particularly solventogenic microorganisms, more particularly C. acetobutylicum. The invention also characterizes a novel domain of the Cel5H cellulase with a putative cellulose-binding module function, and its uses in chimeric proteins for depolymerization of cellulose containing substrates.Type: ApplicationFiled: November 26, 2009Publication date: May 17, 2012Applicants: Total S.A., Le Centre National De Recherche Scientifique (CNRS), L'Institut National des Sciences Appliquees (INSA), L'Universite de Provence, L'Universite de la MediterraneeInventors: Henri-Pierre Fierobe, Angélique chanal-Vial, Anne-Laure Molinier, Chantal Tardif, Luc Dedieu
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Publication number: 20110294184Abstract: The invention relates to applications of a cellulase of Pseudomonas sp. ND137, functional fragments and/or variants and engineered forms thereof, in the context of industrial bioprocessing, more particularly solvent production.Type: ApplicationFiled: November 26, 2009Publication date: December 1, 2011Applicants: Total S.A., Le Centre National De Recherche Scientifique (CNRS), L'Institut National des Sciences Appliquees (INSA), L'Universite de Provence, L'Universite de la MediterraneeInventors: Henri-Pierre Fierobe, Angélique Chanal-Vial
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Publication number: 20110236943Abstract: The present invention relates, inter alia, to recombinant Gram-positive Clostridia host cells for producing solvents, fuels and/or chemical intermediates, and preferably ethanol, from plant cell walls comprising: (a) at least one nucleic acid encoding a plant cell wall degrading enzyme, wherein the host cells produce and secrete the plant cell wall degrading enzyme, (b) at least one nucleic acid encoding an enzyme that converts pyruvate to acetaldehyde and at least one nucleic acid encoding an enzyme that converts acetaldehyde to ethanol wherein the host cell is capable of expressing said nucleic acid, and, (c) a mutation in at least one nucleic acid encoding for an enzyme in a metabolic pathway which produces a metabolite other than acetaldehyde from pyruvate or ethanol from acetaldehyde, such that the mutation results in a reduced production of the metabolite.Type: ApplicationFiled: December 2, 2009Publication date: September 29, 2011Applicants: Total S.A, Le Centre National de Recherche Scientifique (CNRS), L'Universite de la Mediterranee, L'Universite de Provence, L'Institut National des Sciences Appliquees (INSA)Inventors: Laurence Girbal, Florence Saint-Prix, Mathieu Cesari, Henri-Pierre Fierobe, Roberto Mazzoli, Florence Mingardon, Angélique Chanal-Vial
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Publication number: 20110211197Abstract: The disclosure relates to a detection device for imaging an object, that comprises: a laser cavity for transmitting an original light signal at an original wavelength towards the object in order to generate an evanescent wave at the surface of the object; a conversion means adapted for converting the evanescent wave into a progressive signal; a re-injection means adapted for injecting the progressive signal into the laser cavity in order to generate interference inside the laser cavity between the progressive signal and the original light signal; a detection means adapted for detecting the interference in order to determine the characteristics of the object; characterised in that the device includes a wavelength modification means adapted so that the wavelength of the progressive signal injected into the laser cavity is different from the original wavelength.Type: ApplicationFiled: September 3, 2008Publication date: September 1, 2011Applicant: CENTRE NATIONAL DE RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Sylvain Girard, Hervé Gilles, Mathieu Laroche
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Publication number: 20110178013Abstract: The present invention relates to novel octapeptide compounds of general formula (I): H-2-Nal1-cyclo(Cys2-Tyr3-AA4-Lys5-Val6-Cys7)-Thr8-NH2. Since these products have a good affinity for certain somatostatin receptor subtypes, they are particularly advantageous for treating pathological states or diseases in which one (or more) somatostatin receptor(s) is (are) involved. These compounds furthermore have physiochemical properties that make it possible to envisage them in diverse solutions for the formulation of medicaments, for example as a pharmaceutically acceptable carrier. The invention also relates to pharmaceutical compositions containing said products and to the use thereof for the preparation of a medicament.Type: ApplicationFiled: September 29, 2009Publication date: July 21, 2011Applicants: Ipsen Pharma S.A.S., Commissariat a L'Energie Atomique Aux Energies Alternatives (C.E.A.), Le Centre National De Recherche Scientifique (CNRS)Inventors: Marie-Thérèse Paternostre, Jean-Christophe Cintrat, Céline Valery, Stéphane Roux, Bernard Rousseau, Maarten Ijsselstijn, Roland Cherif-Cheikh, Frank Artzner
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Publication number: 20110129876Abstract: Described herein are molecules, constructs and methods for the production and secretion of polypeptides of interest by host cells, preferably bacterial host cells, and more particularly gram positive bacteria. In particular, the present invention is related to a polynucleic acid encoding a fusion protein and to uses thereof for the secretion of heterologous or homologous polypeptides of interest by a bacterial host cell, preferably Clostridium bacteria. The present invention further relates to methods and constructs for the production and secretion of heterologous or homologous polypeptides of interest proteins by host cells using such polynucleic acids and fusion proteins.Type: ApplicationFiled: July 30, 2009Publication date: June 2, 2011Applicants: Total S.A., Le Centre National De Recherche Scientifique (CNRS), L'Universite de la Mediterranee, L'Universite de Provence, L'Instutut National des Sciences Appliquees (INSA)Inventors: Henri-Pierre Fierobe, Florence Mingardon, Angélique Chanal-Vial
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Publication number: 20100190894Abstract: The disclosure relates to a bitumen/polymer composition comprising at least one bitumen and at least one graft polymer, the grafts enabling the bitumen/polymer compositions to be thermoreversibly cross-linked. The disclosure also relates to the use of said bitumen/polymer compositions in fields of application relating to roads, especially in the production of asphalt binders, and in industrial fields of application. The disclosure further relates to the method for producing said thermoreversibly cross-linked bitumen/polymer compositions.Type: ApplicationFiled: July 18, 2008Publication date: July 29, 2010Applicants: TOTAL RAFFINAGE MARKETING, CENTRE NATIONAL DE RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Pierre Chaverot, Charlotte Godivier, Ludwik Leibler, Ilias Iliopoulos, Amanda Kathryn Leach
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Publication number: 20100008894Abstract: The invention relates to a complex formed between the 3?-phosphoadenosine 5?-phosphate and polypeptide in human cells, to the use of pAp or of a molecule which mimics pAp for modulating the activity of poly(ADP-ribose)polymerase and small fragment nuclease in human cells, and to process of screening a molecule as a candidate drug for the treatment of diseases where modulation of at least one of the metabolic activities modulated by pAp is needed such as bipolar disorder or related diseases.Type: ApplicationFiled: September 22, 2006Publication date: January 14, 2010Applicants: Institute pasteur, Centre National De Recherche Scientifique (CNRS)Inventors: Undine Mechold, Vasily Ogryzko, Antoine Danchin