Patents Assigned to Cephelon France
  • Process for enantioselective synthesis of single enantiomers of thio-substituted arylmethanesulfinyl derivatives by asymmetric oxidation
    Patent number: 8183294
    Abstract: The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of: a) contacting a pro-chiral sulphide of formula (II) with a metal chiral complex, a base and an oxidizing agent in an organic solvent; and optionally b) isolating the obtained sulphoxide of formula (I). wherein Ar, Y, R1 are as defined in claim 1.
    Type: Grant
    Filed: January 4, 2011
    Date of Patent: May 22, 2012
    Assignee: Cephelon France
    Inventors: Philippe Louvet, Dominique Schweizer