Patents Assigned to Cerbios Pharma S.A.
  • Process for the preparation of stable, amorphous calcium salt of (6S)-N(5)-methyl-5,6,7,8-tetrahydrofolic acid
    Patent number: 8754212
    Abstract: A process for the preparation of the stable, amorphous calcium salt of (6S)—N(5)-methyl-5,6,7,8-tetrahydrofolic acid of the formula V, and a stable, amorphous calcium salt of (6S)—N(5)-methyl-5,6,7,8-tetrahydrofolic acid of the formula V are provided.
    Type: Grant
    Filed: August 14, 2012
    Date of Patent: June 17, 2014
    Assignee: Cerbios-Pharma S.A.
    Inventors: Raffella Manzotti, Moreno Morosoli
  • PROCESS FOR THE PREPARATION OF STABLE, CRYSTALLINE (6S)-N(5)-METHYL-5,6,7,8-TETRAHYDROFOLIC ACID
    Publication number: 20130040956
    Abstract: A process for the preparation of the stable, amorphous calcium salt of (6S)-N(5)-methyl-5,6,7,8-tetrahydrofolic acid of the formula V, and a stable, amorphous calcium salt of (6S)-N(5)-methyl-5,6,7,8-tetrahydrocolic acid of the formula V are provided.
    Type: Application
    Filed: August 14, 2012
    Publication date: February 14, 2013
    Applicant: CERBIOS-PHARMA S.A.
    Inventors: Raffella MANZOTTI, Moreno Morosoli
  • Stable, crystalline (6S)-N(5)-methyl-5,6,7,8,-tetrahydrofolic acid
    Patent number: 8314102
    Abstract: There is provided a stable, crystalline (6S)-N(5)-methyl-5,6,7,8-tetrahydrofolic acid of the formula IV, This compound belongs to the family of reduced folates which are useful in vitaminic and oncological field.
    Type: Grant
    Filed: May 29, 2008
    Date of Patent: November 20, 2012
    Assignee: Cerbios-Pharma S.A.
    Inventors: Raffella Manzotti, Moreno Morosoli
  • Process for the reduction of pterins
    Patent number: 6162914
    Abstract: The inventive process for the reduction of pterins by means of an alkali metal boron hydride in water to the corresponding 5,6,7,8-tetrahydropterins is characterized in that the reduction is carried out in the presence of a catalytical amount of a water-soluble Pb(II)-salt.
    Type: Grant
    Filed: May 7, 1999
    Date of Patent: December 19, 2000
    Assignee: Cerbios-Pharma S.A.
    Inventors: Nando Toderi, Fabrizio Marazza
  • Concentrated injection solution of alkali metal salts of reduced folates
    Patent number: 5814635
    Abstract: A concentrated, stable solution, especially an injection solution, which comprises water and either sodium-leucovorin or potassium-leucovorin or sodium-N(5)-methyl-5,6,7,8-tetrahydrofolic acid or potassium-N(5)-methyl-5,6,7,8-tetrahydrofolic acid. Also described is a process for the preparation of the solution, as well as its uses.
    Type: Grant
    Filed: July 2, 1997
    Date of Patent: September 29, 1998
    Assignee: Cerbios-Pharma S.A.
    Inventors: Peter Buchs, Fabrizio Marazza
  • Process for the preparation of 9, 10-secocholesta-5,7,10 (19)-trienes
    Patent number: 5698714
    Abstract: The invention recites a process for preparing 9,10-secocholesta-5,7,10(19)-trienes of formula (I) ##STR1## where R.sup.1 is hydrogen or a hydroxy-protecting group and R.sup.2 and R.sup.3 are independently hydrogen or OR.sup.1. The compounds are prepared from epoxides of the following formulas ##STR2## by reaction with a low-valent metal reagent formed by reducing a metal halide, M(z)X.sub.z, preferably WCl.sub.6.
    Type: Grant
    Filed: July 11, 1996
    Date of Patent: December 16, 1997
    Assignee: Cerbios Pharma S.A.
    Inventors: Christof Schickli, Mathias Jud, Fabrizio Marazza