Abstract: Computational fluid dynamics (CFD) can be used for modeling environment characteristics and for controlling instrumentation in sensitive environments, such as in an office building, datacenter, hospital, enclosed arena, airport, or other environment. In an example, power consumption characteristics from physical equipment assets in an environment can be used by a CFD circuit to improve accuracy of a CFD model. Information from a CFD model can be used to optimize efficiency of HVAC or other air-moving systems serving an environment. In an example, CFD analyses can be performed substantially in real-time when one or more inputs to a CFD model change, relative to a baseline value, by more than a specified threshold amount. An energy efficient and cost efficient response to a change in infrastructure of an environment can be identified based on a CFD model of the environment.