Abstract: The present disclosure relates generally to antibodies and functional binding fragments thereof that bind to programmed death-ligand 1 (PD-L1). In particular, the disclosed antibodies and fragments bind to human PD-L1 and comprise novel complementary determining regions (CDRs) also disclosed herein. Finally, the present disclosure relates to administering the disclosed antibodies and fragments to subjects with cancer, thereby treating or slowing the progression or proliferation of the cancer.
Type:
Application
Filed:
October 6, 2023
Publication date:
May 9, 2024
Applicant:
Checkpoint Therapeutics, Inc.
Inventors:
Jonathan BELK, Nathan J. SHARKEY, Leonid GORELIK
Abstract: The present disclosure relates generally to antibodies and functional binding fragments thereof that bind to programmed death-ligand 1 (PD-L1). In particular, the disclosed antibodies and fragments bind to human PD-L1 and comprise novel complementary determining regions (CDRs) also disclosed herein. Finally, the present disclosure relates to administering the disclosed antibodies and fragments to subjects with cancer, thereby treating or slowing the progression or proliferation of the cancer.
Type:
Grant
Filed:
March 13, 2020
Date of Patent:
December 5, 2023
Assignee:
Checkpoint Therapeutics, Inc.
Inventors:
Jonathan Belk, Nathan J. Sharkey, Leonid Gorelik
Abstract: The present disclosure relates generally to antibodies and functional binding fragments thereof that bind to programmed death-ligand 1 (PD-L1). In particular, the disclosed antibodies and fragments bind to human PD-L1 and comprise novel complementary determining regions (CDRs) also disclosed herein. Finally, the present disclosure relates to administering the disclosed antibodies and fragments to subjects with cancer, thereby treating or slowing the progression or proliferation of the cancer.
Type:
Application
Filed:
March 13, 2020
Publication date:
September 3, 2020
Applicant:
Checkpoint Therapeutics Inc.
Inventors:
Jonathan Belk, Nathan J. Sharkey, Leonid Gorelik
Abstract: The present disclosure relates generally to antibodies and functional binding fragments thereof that bind to programmed death-ligand 1 (PD-L1). In particular, the disclosed antibodies and fragments bind to human PD-L1 and comprise novel complementary determining regions (CDRs) also disclosed herein. Finally, the present disclosure relates to administering the disclosed antibodies and fragments to subjects with cancer, thereby treating or slowing the progression or proliferation of the cancer.
Type:
Grant
Filed:
June 28, 2017
Date of Patent:
March 17, 2020
Assignee:
CHECKPOINT THERAPEUTICS, INC.
Inventors:
Jonathan Belk, Nathan J. Sharkey, Leonid Gorelik
Abstract: The present disclosure relates generally to antibodies and functional binding fragments thereof that bind to programmed death-ligand 1 (PD-L1). In particular, the disclosed antibodies and fragments bind to human PD-L1 and comprise novel complementary determining regions (CDRs) also disclosed herein. Finally, the present disclosure relates to administering the disclosed antibodies and fragments to subjects with cancer, thereby treating or slowing the progression or proliferation of the cancer.
Type:
Application
Filed:
June 28, 2017
Publication date:
January 4, 2018
Applicant:
Checkpoint Therapeutics, Inc.
Inventors:
Jonathan BELK, Nathan J. Sharkey, Leonid Gorelik