Patents Assigned to Children's Hospital Research Foundation, a division of Children's Hospital Medical Center
  • Patent number: 5536753
    Abstract: Perfluoroindane is used as a gas transport agent in animals without causing gas or vapor pulmonary embolism. Emulsions containing perfluoroindane as the oxygen carrying component are made and infused into an animal and the perfluoroindane escapes at a very rapid rate from the animal body. The perfluoroindane-containing liquids or emulsions are considered valuable for angioplasty and as a blood substitute.
    Type: Grant
    Filed: November 9, 1990
    Date of Patent: July 16, 1996
    Assignee: Children's Hospital Research Foundation, a division of Children's Hospital Medical Center and HemaGen/PFC
    Inventor: Leland C. Clark, Jr.
  • Patent number: 4775522
    Abstract: A novel and improved method to detect and/or measure indirectly at least one gas, particularly dissolved gases, of an animal employing nuclear magnetic resonance techniques (NMR). The method examines an NMR spectrum to determine chemical shift relaxation times or spin-spin couplings for an element of an animal influenced by at least one gas of the animal. Uniquely, the gas detected according to the principles of this invention may be insensitive to present NMR techniques. Further, the present invention discloses a novel method to determine and monitor gaseous physiological states of an animal. Because of the unique and advantageous non-invasive, non-destructive and non-ionizing properties, the present invention may be employed in an animal continuously and in vivo.
    Type: Grant
    Filed: December 16, 1985
    Date of Patent: October 4, 1988
    Assignee: Children's Hospital Research Foundation, a division of Children's Hospital Medical Center
    Inventor: Leland C. Clark, Jr.