Abstract: A series of novel bis(hydroxymethyl) alkanoate derivatives of curcuminoids were designed, and synthesized, which show anticancer activity, and in particular to breast cancer, colon cancer, and prostate cancer.

Abstract: A method for obtaining a plurality of pluripotent adult olfactory stem cells (APOSCs) includes isolating the APOSCs, culturing the isolated APOSCs in a sphere culture medium, and collecting the cultured APOSCs that express Bmi-1 (B-lymphoma moloney murine leukemia virus insertion region-1), Oct-4 (Octamer-binding transcription factor 4), Sox-2 (Sex-determining region Y (SRY)-box 2), Nanog, SSEA-4 (Stage-specific embryonic antigen-4), ki67, c-Myc, KLF-4 (Kruppel Like Factor 4), K14 (Cytokeratin 14) and ICAM-1 (Intercellular Adhesion Molecule 1).

Abstract: An immunomagnetic nanocapsule includes a core, a shell and an outer layer. The shell is formed by a complex, and the complex is fabricated by a combination of fucoidan, oxidized dextran, and a plurality of superparamagnetic iron oxide nanoparticles via a hydrophobic interaction. The core is encapsulated in the shell. The outer layer includes at least one antibody immobilized to outside of the shell to form the outer layer, wherein the antibody is an immune checkpoint inhibitor and/or a T cell expansion antibody.

Abstract: A liver fibrosis assessment model includes following establishing steps. A reference database is obtained, wherein the reference database includes a plurality of reference blood test data. A preprocessing step of the blood test data is performed. A feature extracting step is performed, wherein the feature extracting step is for extracting at least one eigenvalue according to the reference database. A normalizing step of the blood test data is performed. A classifying step is performed, wherein the classifying step is for achieving a convergence of the normalized reference blood test data by using a gradient boosting algorithm so as to obtain the liver fibrosis assessment model. The liver fibrosis assessment model is used to assess whether a subject suffers from liver fibrosis and predict a degree of liver fibrosis of the subject.

Abstract: A method for enhancing an expression of insulin like growth factor 1 receptor in a mesenchymal stem cell is provided. The method includes culturing the mesenchymal stem cell expressing insulin-like growth factor 1 receptor in a medium containing platelet-derived growth factor BB (PDGF-BB) to enhance the expression of insulin like growth factor 1 receptor in the mesenchymal stem cell.

Abstract: A composition including adult pluripotent olfactory stem cells is provided. The adult pluripotent olfactory stem cells are obtained by culturing a cell mixture from an olfactory tissue of a mammal in media containing growth factors and then isolating cells which express B-lymphoma moloney murine leukemia virus insertion region-1 (Bmi-1).

Abstract: A method for enhancing an insulin like growth factor 1 receptor expression of a mesenchymal stem cell is provided. The method includes culturing a plurality of mesenchymal stem cells expressing insulin-like growth factor 1 receptors in media containing human cord blood serum to enhance the insulin like growth factor 1 receptor expression of the mesenchymal stem cells.

Abstract: The present disclosure relates to a method for predicting a recurrence and a progression of an urothelial cancer patient after a treatment including steps as follows. A urine sample is obtained from a subject. The urine sample is performing a serially centrifugation step to obtain a third precipitate. The third precipitate is resuspended with an extraction solvent to obtain a third mixture, and the third mixture is centrifuged to obtain a fourth supernatant. The fourth supernatant is analyzed by a mass spectrometry to detect whether there is a particular peptide therein.

Abstract: The invention surprisingly found that agents that inhibit system xc? provide the therapeutic intervention in substance-related and addictive disorders and the treatment and/or prevention in substance-mediated brain damage and confirms that system xc? is a promising therapeutic target for substance-induced addiction and brain damage.

Abstract: A method for diagnosing Alzheimer's disease (AD) includes: obtaining a blood sample from a human subject suspected of having AD; determining a G72 protein level in the blood sample; determining an SLC7A11 mRNA expression level in the blood sample; comparing the G72 protein level with a first predetermined standard; comparing the SLC7A11 mRNA expression level with a second predetermined standard; and diagnosing the human subject with AD when the G72 protein level is higher than the first predetermined standard and the SLC7A11 mRNA expression level is higher than the second predetermined standard. An effective amount of a pharmaceutical composition may be administered to the diagnosed human subject for treating AD.

Abstract: An assisted detection system of breast tumor includes an image capturing unit and a non-transitory machine readable medium. The non-transitory machine readable medium storing a program which, when executed by at least one processing unit, determines a breast tumor type of the subject and predicts a probability of a tumor location of the subject. The program includes a reference database obtaining module, a first image preprocessing module, an autoencoder module, a classifying module, a second image preprocessing module and a comparing module.

Abstract: A three-dimensional serial focused intraoral digital tomosynthesis scanner includes a frame body, an image capturing module, a photosensitive member and an image processing module. The frame body includes a central axis and a light source seat which is moved along a scanning path and rotated around the central axis. The image capturing module is disposed on the light source seat and reciprocated along the scanning path. The image capturing module is configured to generate a light beam emitted from an outside to the patient's mouth. The photosensitive member is positioned in the patient's mouth. The light beam is emitted to the photosensitive member and moved along the scanning path corresponding to the photosensitive member so as to generate a plurality of two-dimensional optical images by the image capturing module. The image processing module calculates the two-dimensional optical images to generate a three-dimensional image.

Abstract: Disclosed herein is a refined product obtained from a rice hull, which consists essentially of a type II arabinogalactan having a number average molecular weight in the range of 56 to 103 kDa. Also disclosed are a process for producing the refined product and use of the refined product for enhancing the biological activity of innate immune cells, as well as for treating allergy and cancer.

Abstract: The present disclosure relates to a method for validating an existence of a urinary exosome including steps as follows. A urine sample is obtained from a subject. The urine sample is performing a serially centrifugation step to obtain a third precipitate. The third precipitate is resuspended with an extraction solvent to obtain a third mixture, and the third mixture is centrifuged to obtain a fourth supernatant. The fourth supernatant is analyzed by a mass spectrometry to detect whether there is a particular peptide therein.

Abstract: A method of evaluating if a glioblastoma multiforme (GBM) patient is applicable to be treated with an immunotherapy based on dendritic cell tumor vaccines includes a sample obtaining step to obtain a sample from the GBM patient, a detecting step to detect an expression level of a biomarker, and a comparing step to compare the expression level of the biomarker to a threshold, wherein the GBM patient is applicable to treat with the immunotherapy based on dendritic cell tumor vaccines when the expression level of the biomarker is lower than the threshold. A method of prognosticating a survival rate in the GBM patient after a treatment includes a sample obtaining step, a detecting step, and a comparing step, wherein the GBM patient is determined to have a good prognosis after the treatment when the expression level of the sample from the GBM is lower than the threshold.

Abstract: The present disclosure relates to a bicyclic compound, a pharmaceutical composition thereof, and its novel use. More particularly, the present disclosure relates to the bicyclic compound according to Formula I or Formula II, the pharmaceutical composition for treating a stroke, and the use of the bicyclic compound treating the stroke.

Abstract: A method for treating osteoporosis in a subject in need thereof comprising administering to the subject an effective amount of a composition comprising a compound of formula I or pharmaceutically acceptable salts thereof.

Abstract: A method for treating pancreatic cancer is provided. The method comprises administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical formulation, wherein the pharmaceutical formulation comprises (Z)-butylidenephthalide and is substantially free of (E)-butylidenephthalide.

Abstract: A method for alleviating at least one of the disturbance of bile acid metabolism, the disturbance of amino acid metabolism, and the disturbance of gut microbiota metabolism in a subject, comprising administering to the subject a composition or a health food comprising an active component selected from the group consisting of gallic acid, a pharmaceutically acceptable salt of gallic acid, a pharmaceutically acceptable ester of gallic acid, and combinations thereof.

Abstract: A use of an active ingredient in the manufacture of a medicament or a preparation is provided, wherein the active ingredient is at least one of ergstatrien-3?-ol and a pharmaceutically acceptable ester thereof, the medicament is for alleviating, inhibiting and/or treating the hepatic injuries caused by alcohol consumption, or for alleviating and/or inhibiting body fat accumulation caused by alcohol consumption, and the preparation is a food or a food additive for increasing the alcohol metabolism capability of the liver.