Abstract: A highly sensitive inertial mouse is in particular to one using an MEMS(Micro-Electrical-Mechanical System)inertial sensitive principle; the mouse uses MEMS inertial sensitive principle including a two-dimensional or three-dimensional inertial sensors or accelerometers and with the use of signal processing methods such as collecting of data, noise cancellation, setting of threshold of dead zone, tracking of baseline, calculation of displacement and adjustment of sensitivity and so on, enable the MEMS sensor acting as the manufacturing component of a computer mouse; furthermore, the present invention is not only light and energy saving, but also obviates the drawbacks of high power consumption of optics mice or easy-dirt collection of roller mice. Moreover, with the increase in sensitivity, the bottleneck in the manufacturing of inertial mouse is overcome such that the functions of MEMS inertial mouse is very stable and reliable and can be easily used.