Abstract: The invention relates to the identification and selection of sequences which demonstrate particular advantage in identifying individuals having osteoarthritis (OA). The invention also provides a selection of sequences particularly useful in diagnosing the degree of advancement of osteoarthritis of an individual and in the identification of novel therapeutic targets for OA. The invention further provides for the use of these sequences as a tool to diagnose disease progression and to monitor the efficacy of therapeutic regimens.
Type:
Grant
Filed:
September 12, 2002
Date of Patent:
March 15, 2011
Assignee:
Chondrogene, Inc.
Inventors:
Choong-Chin Liew, Wayne Marshall, Hongwei Zhang
Abstract: The present invention provides systems and method for constructing classifiers that distinguish between trait subgroups using molecular marker data from blood samples. The invention further encompasses the use of the classifiers and combinations of molecular markers identified by the classifiers in a wide variety of applications including: diagnosis; prognosis; prediction of disease, stage of disease or disease risk; monitoring disease progression and/or regression; monitoring disease reoccurrence and identifying risk of disease reoccurrence; determining and/or predicting response to treatment and/or treatment outcomes; monitoring and/or predicting treatment compliance or non compliance and the like. The invention further provides a variety of selected molecular markers and a means to identify combinations of the selected molecular markers useful for diagnosing particular traits of interest.
Type:
Application
Filed:
June 20, 2005
Publication date:
November 22, 2007
Applicant:
CHONDROGENE, INC.
Inventors:
Choong-Chin Liew, Thomas Yager, Adam Dempsey, Samuel Chao