Abstract: Provided are a series of Gq protein competitive inhibitory polypeptides (GCIPs), polynucleotides encoding them, and preparation methods thereof. Also provided are pharmaceutical compositions comprising GCIP polypeptides and their uses in the manufacture of drugs for treating myocardial hypertrophy.
Type:
Grant
Filed:
August 11, 2008
Date of Patent:
April 15, 2014
Assignees:
Third Military Medical University, Chongqing Zhaokanglihui Meditech Co., Ltd., Chongqing Qingyang Pharmaceutical Co., Ltd.
Inventors:
Xiaohui Li, Haigang Zhang, Jianzhi Zhou, Shuhui Li