Abstract: A wheel hub seal has an inner annular member. An outer side of the inner annular member is sleeved with an outer annular member. A passage is formed between the inner annular member and the outer annular member. An opening of the passage is provided with a second barrier. The second barrier has a fixed portion fixed to the outer annular member. The fixed portion extends toward the inner annular member to form a suspended flexible portion. An outer surface of the flexible portion is provided with a raised press portion. Thereby, when the wheel hub seal is mounted in a shaft hole of a hub, the press portion is compressed by the inner wall of the shaft hole to press the flexible portion to resiliently lean against the inner annular member to seal the passage, achieving the effect of blocking external silt.