Patents Assigned to Chung Shan Medical University
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Publication number: 20230377745Abstract: A method of establishing a clinical decision support system for SPC risk evaluation among patients with colorectal cancer includes combining cancer characteristics into a characteristic assembly of SPC risk evaluation; obtaining clinical data of first participants to establish a database of SPC risk evaluation; entering the database into a machine learning algorithm; using the machine learning algorithms to establish a SPC risk evaluation model; using a characteristic interpreter to analyze the model; calculating a risk value of each cancer characteristic; presenting the risk values in graphics to establish a clinical decision support system; obtaining clinical data of second participants and inputting same into the clinical decision support system; using the machine learning algorithm for comparison and analysis; predicting risk for SPC; calculating a risk value of each cancer characteristic; presenting the risk values on the clinical decision support system; giving suggestions of decreasing risk; and monitoType: ApplicationFiled: May 17, 2022Publication date: November 23, 2023Applicant: Chung Shan Medical UniversityInventors: Chi-Chang Chang, Chi-Jie Lu, Yi-Ju Tseng, Ssu-Han Chen, Chin-Jen Tseng
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Publication number: 20230215001Abstract: A method for facilitating caries detection is to be performed based on a grayscale image of teeth, and includes: obtaining an object detection model; obtaining a detection image using the object detection model based on the grayscale image, wherein the detection image is the grayscale image labeled with a plurality of tooth crown marks and a caries mark; and for one of the tooth crown marks that has the caries mark provided thereon, determining a width and a height of the tooth crown mark and a width and a height of the caries mark, and calculating a caries ratio based on the aforementioned widths and heights to obtain an evaluation result that indicates a severity of caries.Type: ApplicationFiled: December 16, 2022Publication date: July 6, 2023Applicant: CHUNG SHAN MEDICAL UNIVERSITYInventors: Chia-Tze KAO, Chih-Jen TSENG
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Patent number: 11591368Abstract: The invention pertains to cancer treatment or prevention field. Particularly, the invention provides peptide fragments from SLIT2 protein and their applications in inhibition of cancer growth, invasion and metastasis.Type: GrantFiled: April 27, 2018Date of Patent: February 28, 2023Assignees: CHUNG SHAN MEDICAL UNIVERSITY, TUNGHAI UNIVERSITYInventors: Jinghua Tsai Chang, Feng-Di Lung
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Patent number: 11197904Abstract: The present invention relates to the area of pharmaceutical compositions. More particularly, the present invention relates to a series of pharmaceutical compositions (PTM) containing phyto-polyphenols (P), clinical drugs with selective targets (T) and a metal ions (M) and the methods thereof for use in prevention and therapy of infectious diseases, neurodegenerative diseases, dementia, diabetes, obesity, metabolic syndromes, osteoporosis, cancers and/or chronic pain.Type: GrantFiled: January 20, 2019Date of Patent: December 14, 2021Assignees: Chung Shan Medical UniversityInventor: Shoei-Yn Lin-Shiau
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Publication number: 20210346444Abstract: The present invention provides a composition comprising Nelumbo nucifera leaf extract and a method for the increase of adult hippocampal neurogenesis.Type: ApplicationFiled: May 6, 2020Publication date: November 11, 2021Applicant: Chung Shan Medical UniversityInventors: Chau-Jong Wang, Yen-Ling Chang
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Publication number: 20210038567Abstract: The present invention relates to a method for inhibiting a cancer metastasis in a subject in need thereof, comprising administering to said subject a cancer metastasis-inhibiting effective amount of: Camphorataimide B; or a composition comprising Camphorataimide B and a pharmaceutically acceptable adjuvant, vehicle, or carrier.Type: ApplicationFiled: August 9, 2019Publication date: February 11, 2021Applicant: Chung Shan Medical UniversityInventors: Chau-Jong Wang, Chia-Hung Hung
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Patent number: 10912760Abstract: The present invention relates to a method for inhibiting a cancer metastasis in a subject in need thereof, comprising administering to said subject a cancer metastasis-inhibiting effective amount of: Camphorataimide B; or a composition comprising Camphorataimide B and a pharmaceutically acceptable adjuvant, vehicle, or carrier.Type: GrantFiled: August 9, 2019Date of Patent: February 9, 2021Assignee: Chung Shan Medical UniversityInventors: Chau-Jong Wang, Chia-Hung Hung
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Patent number: 10448878Abstract: Many electrodes are positioned inside a skull for obtaining several electric voltage variation wave information. A processing unit computes subtract operation between two neighboring electrical voltage variation wave information respectively and then can obtain electrical voltage difference waves. Furthermore, each electrical voltage difference wave is separated into a first band wave signal and a second band wave signal. After which, several first band wave envelope signals and second band wave envelope signals are obtained. It conducts a co-relation processing about the first band wave envelope signals and the second band wave envelope signals. So, a co-relation table is obtained for determining a position where an intracranial brain wave abnormality occurs. In this invention, a unique scientific approach to determine the spatial position of seizure onset occurred inside the brain. In addition, the position of intracranial brain wave abnormality can be concretized and visualized by the co-relation table.Type: GrantFiled: April 17, 2017Date of Patent: October 22, 2019Assignee: CHUNG SHAN MEDICAL UNIVERSITY HOSPITALInventors: Yue-Loong Hsin, Syu-Jyun Peng
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Publication number: 20170246233Abstract: The invention relates to a method of decreasing blood sugar by inhibition of ?-glucosidase activity in a subject in need thereof, comprising administering pu-erh tea polysaccharides (PTPS) to the subject, wherein the active ingredients in PTPS are neutral sugar, protein, polyphenol, and uronic acids.Type: ApplicationFiled: February 26, 2016Publication date: August 31, 2017Applicant: Chung Shan Medical UniversityInventors: Shoei-Yn Lin-Shiau, Jen-Kun Lin
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Publication number: 20160263050Abstract: The present invention provides a method for inducing death of a cancer cell in a subject in need thereof comprising administering to the subject a pharmaceutically effective amount of Nelumbo Nucifera leave water extract, wherein the Nelumbo Nucifera leave water extract comprises polyphenols.Type: ApplicationFiled: March 13, 2015Publication date: September 15, 2016Applicant: Chung Shan Medical UniversityInventors: Chau-Jong Wang, Mon-Yuan Yang, Tzu-Hsin Chen
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Patent number: 9326988Abstract: Disclosed herein is a method for treatment of a human subject having or suspected of having Parkinson's disease dementia, which includes administering to the human subject ceftriaxone at a daily dosage ranging from about 1.5 mg to about 35 mg per kilogram of a body weight of the human subject.Type: GrantFiled: March 13, 2013Date of Patent: May 3, 2016Assignees: CHUNG SHAN MEDICAL UNIVERSITY, TL & GM CHEMICAL COMPANYInventor: Ying-Jui Ho
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Publication number: 20130296294Abstract: Disclosed herein is a method for treatment of a human subject having or suspected of having Parkinson's disease dementia, which includes administering to the human subject ceftriaxone at a daily dosage ranging from about 1.5 mg to about 35 mg per kilogram of a body weight of the human subject.Type: ApplicationFiled: March 13, 2013Publication date: November 7, 2013Applicants: TL & GM Chemical Company, CHUNG SHAN MEDICAL UNIVERSITYInventor: Ying-Jui HO
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Publication number: 20110232533Abstract: One aspect of the present invention provides a method for producing calcium silicate-based bone cement, including the steps of mixing calcium salt with silicohydrides to form a first mixture; processing the first mixture with a sol-gel process to form a second mixture; heating the second mixture to form a dried mixture; grinding the second mixture into powder; and adding the powder to water or phosphate solution.Type: ApplicationFiled: May 19, 2011Publication date: September 29, 2011Applicant: CHUNG SHAN MEDICAL UNIVERSITYInventor: SHINN JYH DING
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Patent number: 8003766Abstract: This invention provides a monoclonal antibody specific to ochratoxin A and methods of assaying the level of ochratoxin A in food and feed.Type: GrantFiled: April 17, 2009Date of Patent: August 23, 2011Assignee: Chung Shan Medical UniversityInventor: Feng-Yih Yu
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Publication number: 20110160260Abstract: The present invention provides a method of treating a neurodegenerative disorder in a patient, comprising administration to the patient a therapeutically effective amount of D-cycloserine and its derivatives.Type: ApplicationFiled: November 5, 2010Publication date: June 30, 2011Applicants: Chung Shan Medical University, T.L. & G.M. Chemical CompanyInventor: Ying-Jui Ho
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Publication number: 20100266603Abstract: This invention provides a monoclonal antibody specific to ochratoxin A and methods of assaying the level of ochratoxin A in food and feed.Type: ApplicationFiled: April 17, 2009Publication date: October 21, 2010Applicant: CHUNG SHAN MEDICAL UNIVERSITYInventor: Feng-Yih Yu
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Publication number: 20100221368Abstract: A method for inhibition a cytokine, transgluaminase type 2 (TG2) or matrix metalloproteinase 9 (MMP-9) was provided.Type: ApplicationFiled: February 27, 2009Publication date: September 2, 2010Applicant: CHUNG SHAN MEDICAL UNIVERSITYInventor: Gregory J. Tsay
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Publication number: 20100196514Abstract: The present invention provides a method for producing calcium silicate-based bone cement and a composition produced by the method. It further provides a novel composition for bone tissue repair.Type: ApplicationFiled: February 2, 2009Publication date: August 5, 2010Applicant: Chung Shan Medical UniversityInventor: Shinn-Jyh Ding
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Patent number: 7662413Abstract: The present invention provides Nelumbo extract and a method thereof. The present invention further provides a composition comprising said extract and a method for treating subject suffering from breast cancer with the composition.Type: GrantFiled: February 27, 2008Date of Patent: February 16, 2010Assignees: Chung Shan Medical UniversityInventors: Chau-Jong Wang, Mong-Yuan Yang
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Publication number: 20090299233Abstract: A device for measuring functional reach is disclosed, which comprises three parts: a support, one end thereof being attached to an object; a ruler, one end thereof being connected to the support; and a vernier, being connected to the ruler and moving on the ruler forward and backward. The invention is used for a functional evaluation test for measuring balance.Type: ApplicationFiled: May 4, 2009Publication date: December 3, 2009Applicant: CHUNG SHAN MEDICAL UNIVERSITYInventors: Ching-Yi Wang, Yung-Wen Tang